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High-grade glioma

Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models

Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models

... 9 high grade glioma cell ...the glioma cell lines except in the DNA-PK deficient MO59J cell line, Dbait induced phosphorylation of H2AX (Figure ...

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MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model

MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model

... of high-grade glioma is greater than 5 per 100,000 people, and this disease leads to 3% of all cancer deaths for patients aged 35 to 64 years 11 ...(WHO grade IV) with the worst ...

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Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma

Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma

... notably high grade ...recurrent high grade glioma because of its ability to ac- curately deliver high doses of RT in a single or several fractions and to spare surrounding normal ...

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Objective neurocognitive functioning and neurocognitive complaints in patients with high-grade glioma: Evidence of cognitive awareness from the European Organisation for Research and Treatment of Cancer brain tumour clinical trials

Objective neurocognitive functioning and neurocognitive complaints in patients with high-grade glioma: Evidence of cognitive awareness from the European Organisation for Research and Treatment of Cancer brain tumour clinical trials

... with high-grade gliomas (World Health Organisation [WHO] grades IIIeIV) cannot be cured, palliation of symptoms and maintenance or even improvement of physical functioning and health-related quality of life ...

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The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

... NSCs from the SVZ present an increased resistance to TMZ and radiation therapy ( 21 , 23 ). This radioresistance can be explained in part by high expression of the anti-apoptotic proteins Bcl2 and Mcl1 ( 94 ). ...

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Ultrasmall theranostic gadolinium-based nanoparticles improve high-grade rat glioma survival

Ultrasmall theranostic gadolinium-based nanoparticles improve high-grade rat glioma survival

... a glioma model. The 9L glioma cells were orthotopically implanted in 10-week-old Fischer ...in high grade glioma, as well as the potential survival benefits when combined with ...

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Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma

Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma

... 2.5. RsfMRI pre-processing The following preprocessing steps were achieved using the CONN Toolbox (functional connectivity toolbox, release 18.b) ( Whitfield- Gabrieli and Nieto-Castanon, 2012 ) under MATLAB environment ...

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High rate of PIK3CA mutations but no TP53 mutations in low-grade adenosquamous carcinoma of the breast

High rate of PIK3CA mutations but no TP53 mutations in low-grade adenosquamous carcinoma of the breast

... Typically, the carcinomatous component is charac- terised by small glandular structures with rounded rather than angulated contours, and solid cords of epithelial cells that may contain squamous cells, squamous pearls, ...

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Conditional Probability of Survival and Prognostic Factors in Long-Term Survivors of High-Grade Serous Ovarian Cancer

Conditional Probability of Survival and Prognostic Factors in Long-Term Survivors of High-Grade Serous Ovarian Cancer

... 4. Patients and Methods 4.1. Database The ovarian cancer database at our institution was created in 1995 and has been regularly implemented since then. It currently holds information on around 600 patients with ...

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Curling of concrete slabs on grade

Curling of concrete slabs on grade

... on grade tend to curl up at joints and around the perimeter, sometimes causing the slab to lose contact with the subbase ...forklifts, high-reach stackers and other specialized equipment to operate safely ...

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Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

... transcriptomics. We have studied, in the context of oncolytic virotherapy, the susceptibil- ity of different grades of primary low-passage mammary carcinoma cells of canine origin to an oncolytic vaccinia virus (VV). We ...

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Glioma resection and tumor recurrence : back to Semmelweis.

Glioma resection and tumor recurrence : back to Semmelweis.

... regards glioma recurrence at the resection margin, accumulative evidence suggests that the tissue response to SBI participates in the formation of recurrence-prone ...

4

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

... yield high linear energy transfer alpha particles and recoiling lithium-7 ...of high grade gliomas, recurrent cancers of the head and neck region and either primary or metastatic ...

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A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI

A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI

... C-methionine better discriminates post-RT necrosis from tumour recurrence [19] but it is rarely available in daily practice. Recently, the DSC-MR technique was proposed for adult high-grade gliomas in this ...

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Building Weathertight Masonry Walls Above Grade

Building Weathertight Masonry Walls Above Grade

... In view of the relatively high drying shrinkage likely to be exhibited by concrete and sand-lime products, it is recommen- ded that キセャャウ built of these units be laid with a mortar havin[r] ...

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Akt signaling pathway: a target for radiosensitizing human malignant glioma

Akt signaling pathway: a target for radiosensitizing human malignant glioma

... radiosensitize glioma cell lines with PTEN wild ...radiosensitize glioma because PTEN is often mutated in these ...PTEN glioma cells (SF763, SF767 38 ), but these two cell lines were selected for ...

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MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas

MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas

... MAP3K8 function in tumour development is highly con- troversial 32,45,63,64 . A major issue is whether MAP3K8 has deleterious or beneficial effects on tumour growth and cancer patient outcome. Our study addresses this ...

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Primary high-grade B-cell central nervous system lymphoma in a patient with tumefactive multiple sclerosis treated with Natalizumab.

Primary high-grade B-cell central nervous system lymphoma in a patient with tumefactive multiple sclerosis treated with Natalizumab.

... Discussion and conclusion: Primary CNS lymphoma (PCNSL) is a rare high-grade non-Hodgkin’s lymphoma. In immunocompetent patients, they are almost exclusively of B-cell type with an incidence of 0,3/100 000 ...

1

Simulation of patient-specific glioma models for therapy planning

Simulation of patient-specific glioma models for therapy planning

... Image based tumor modeling describes the average behavior of tumor cells, macroscopic effects, and general features at an organ level, such as tumor invasion in white and gray matter, or [r] ...

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Weathering characteristics of coating-grade asphalts

Weathering characteristics of coating-grade asphalts

... A good correlation is found between t h e dispersibility of the asphaltenes and t h e durability of coating grade asphalts produced from straight run, crude blend, oil[r] ...

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