Hematological malignancies
Natural killer cells modulation in hematological malignancies
... Keywords: hematological malignancies, natural killer cells, natural cytotoxicity receptors, immune escape, immunotherapy INTRODUCTION The natural killer (NK) cells are central players in innate immunity ...
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Perforin-1 does not appear to be associated with familial hematological malignancies.
... familial hematological malignancies (call for proposal 2005) and the GenHem- INSERM/DGRS Franco- Tunisian project, and this net- work was supported by the French National Cancer Institute ...of ...
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Development and evaluation of a real-time PCR assay for detection and quantification of blastocystis parasites in human stool samples: prospective study of patients with hematological malignancies.
... qPCR was able to quantify both cyst and vacuolar forms, and it is possible that the vacuolar form gives a better reflection of pathogenicity, as suggested by Elwakil and Hewedi (5). In our study, Giardia intestinalis ...
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RECQ helicases are deregulated in hematological malignancies in association with a prognostic value
... Methods Databases: We used Oncomine Cancer Microarray database (http://www.oncomine.org) [22] and Geno- micscape (http://genomicscape.com/) [63] to study gene expression of RECQ family members in nine dif- ferent human ...
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Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center
... certain hematological malignancies, including B-cell non-Hodgkin lymphoma (NHL) and B-cell acute lymphoblastic leukemia ...B-cell malignancies (NHL, ALL, CLL) and MM, ...B-cell malignancies; ...
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Monitoring NK cell activity in patients with hematological malignancies
... hematological neoplasms can be roughly classified into lympho- mas and leukemias. The former are lymphoid tumors initially confined to peripheral lymphoid organs and extranodal tissues, while the latter include ...
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Estimating the treatment effect from non-randomized studies: The example of reduced intensity conditioning allogeneic stem cell transplantation in hematological diseases.
... Background: In some clinical situations, for which RCT are rare or impossible, the majority of the evidence comes from observational studies, but standard estimations could be biased because they ignore covariates that ...
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The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism
... in hematological malignancies, p53 mutation frequency increases with tumor progression to more aggressive or advanced stages and it is strongly associated with chemo-resistance and poor prognosis [26–29, ...
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Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.
... of hematological malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus and showed that the breakpoints were more widely distributed than previously ...
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Occupation and lymphoid malignancies: results from a French case-control study.
... the Hematological Malignancies Registry of Gironde, who helped with the classification and coding and Professor Libersa who supported data collection in ...
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Cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy: A longitudinal cohort study
... with hematological malignancies undergoing chemotherapy are at risk for altered cognitive compensatory processes in novel and non ‐novel contexts, suggesting that these processes should be addressed in ...
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Dissecting the NK cell population in hematological cancers confirms the presence of tumor cells and their impact on NK population function
... 4. Discussion We have used here a non-supervised UMAP analysis of multiparametric FACS data to unveil new classical NK cell (cNK) subpopulations or clusters in HL and AML patients. We first verified whether HL patients ...
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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
... of hematological malignancies; (2) despite their similar catalytic activities in oxidi- zation of 5mC, Tet1 is required for the Tet2-deletion-mediated HSC dysregulation, myeloid skewing, and myeloid ...
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Targeted Therapies in Adult B-Cell Malignancies
... for hematological malignancies in leukemias and T-cell lymphoma, with both inducers of Warburg effect, PKM2, and HIF-1𝛼, reported to be involved in AML and connected to epigenetic control of gene expression ...
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The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies
... Koch Institute for Integrated Cancer Research at MIT, Cambridge, Massachusetts, United States of America * hemann@mit.edu Abstract Aberrant chromatin regulation is a frequent driver of leukemogenesis. Mutations in ...
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Clinical impact of (99m)Tc-MAA SPECT/CT-based dosimetry in the radioembolization of liver malignancies with (90)Y-loaded microspheres
... To achieve the best efficacy and lowest toxicity pro- file, the tumor absorbed dose (TD) and that absorbed by healthy injected liver tissue (HILD) should be evaluated prior to commencing[r] ...
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Hematopoietic progenitor cell mobilization and harvesting in children with malignancies: do the advantages of pegfilgrastim really translate into clinical benefit?
... This high efficiency is probably due to the fact that the serum G-CSF rises quickly and markedly after the injection, and remains elevated up to the third day. 5 BM stimulation is immediately maximal, as shown by the fact ...
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Chimeric antigen receptor T-cells: a new therapeutic option for relapsed/refractory B-cell malignancies and beyond
... PMBCL, TFL). These initial successes provide a foundation to also develop this treatment strategy in other cancers types, such as MM or CLL. However, the intense immune activation induced by CAR T-cell therapy may also ...
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Prevention of Invasive Aspergillus Fungal Infections with the Suspension and Delayed-Release Tablet Formulations of Posaconazole in Patients with Haematologic Malignancies
... Elisabeth Leclerc 1 , David Combarel 1 , Madalina Uzunov 2 , Véronique Leblond 3 , Christian Funck- Brentano 4,5 & Noël Zahr 1 Posaconazole is a triazole antifungal used to prevent invasive fungal infections (IFIs) ...
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Effects of Alexandrium minutum exposure upon physiological and hematological variables of diploid and triploid oysters, Crassostrea gigas.
... Ef- fects of Alexandrium minutum exposure upon physiological and hematological variables of diploid and triploid oysters, Crassostrea gigas.... Effects of Alexandrium minutum exposure up[r] ...
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