Hedgehog signaling
Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing
... morphogenetic Hedgehog signaling pathway and its main effectors, Sonic Hedgehog (SHH) and Desert Hedgehog (DHH) in the regenerative drive following nerve ...dysfunctional Hedgehog ...
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Hedgehog signaling modulates glial proteostasis and lifespan
... at 20 flies per vial and transferred to fresh vials every two days while being scored for survival. A minimum of 180 to 300 flies were used per genotype per lifespan assay, unless otherwise indicated. ...
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Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.
... In order to gain new insight into the regulation and the function of the Su(fu) protein, we monitored its accumulation and post- translational modifications and analyzed the effects of its overexpression. First, we show ...
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Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
... HH signaling, the effect of Npx on the expression of IHH, GLI1, GLI2, GLI3 and PTC1 was analyzed with real-time RT ...HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also ...
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The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.
... SHH signaling pathways have been shown to be the main sign- aling events involved in nephrogenesis ...SHH signaling pathways in human ...SHH signaling activation through SHH ligand induction in ...
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Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus
... synaptic transmission without affecting the glutamatergic component. This selective action of SAG on GABAergic synaptic currents reveals one plausible mechanism underlying Shh-Smo modulation of GDP frequency in the ...
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The importance of the Hedgehog signaling pathway at the level of the blood-brain barrier
... Sonic Hedgehog and human blood-brain barrier endothelial cells express receptor, Patched-1 and signal transducer ...of Hedgehog (Hh) pathway components by astrocytes and BBB-ECs revealed by western blots ...
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Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
... KDR expression in triple-negative breast cancers [ 87 ] while Ihh expression has been associated with Vegf expression and CD34 staining in hepatocellular carcinoma [ 88 ]. Hyperactivation of Hh signaling in ...
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Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
... Hh signaling ( Mukhopadhyay et ...Hh signaling in MEFs lacking Inpp5e, sug- gesting that overaccumulation of Tulp3 in cilia is a key factor in the observed signaling ...Hh signaling is ...
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Les inhibiteurs de la voie Hedgehog - Un espoir pour le traitement des carcinomes basocellulaires
... Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth ...
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Slit-Robo signaling
... KEY WORDS: Robo, Slit, Angiogenesis, Axon guidance, Development, Migration Introduction In all organisms with bilateral symmetry, axon tracts connect the left and the right half of the central nervous system (CNS) during ...
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The hedgehog receptor patched is involved in cholesterol transport.
... Shh signaling, inhibits Patched expression and reduces BODIPY-cholesterol efflux, while treatment with the Shh pathway agonist SAG enhances Patched protein expression and BODIPY-cholesterol ...
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Effet de la dérégulation de la voie Sonic Hedgehog sur les réponses aux dommages de I'ADN et la prédisposition aux cancers
... 151 globale de la signalisation des dommages à l’ADN impactant plus particulièrement les voies de réparation de l’ADN spécialisées dans le stress oxydant. L’utilisation de l’étude par protéomique nous a aussi permis de ...
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The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog
... a signaling center that secretes Sonic Hedgehog (Shh) to control the growth and regionalization of the caudal ...the signaling center of the caudal ...
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Cilia, ciliopathies and hedgehog-related forebrain developmental disorders
... several signaling pathways essential during development and perturbed in genetic disease and/or cancer, such as the Hh (see below), Wnt ( Gerdes and Katsanis, 2008 ; Wallingford and Mitchell, 2011 ), PDGFa ( ...
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Étude du mécanisme d’activation de la voie de signalisation canonique de Hedgehog chez la drosophile
... Un grand merci à Pascal, ou plus communément appelé « papi » (désolée Pascal, mais « papa » est déjà réservé) de m’avoir accueillie au sein de son laboratoire, moi petite master, et de m’avoir permis d’effectuer une ...
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Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis
... (Cell Signaling ® , Danvers, MA, USA; Cat# 11818), β-actin (Cell Signaling ® , Cat# 5125), and goat α-rabbit IgG (Jackson Immunoresearch Laboratory ® , West Grove, PA, USA; Cat# ...
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Signaling in the Phytomicrobiome
... The best understood example of signaling between a plant and elements of the phytomicrobiome occurs between leguminous plants and associated nitrogen-fixing rhizobia ( Lira et al.; Nelson and Sadowsky; Smith et ...
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New insights on marginally trapped surfaces: the hedgehog theory point of view
... In addition, a huge class of marginally trapped surfaces correspond by ad- junction to hedgehogs (envelopes parametrized by their Gauss map) and can thus bene…t directly from contributions of hedgehog theory, ...
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Division symétrique ou division asymétrique : Sonic Hedgehog contrôle le destin des cellules souches neurales adultes
... liés à l’apprentissage, à l’activité phy- sique, au stress ou au vieillissement. Les CSN sont également essentielles au processus de régénération du tissu céré- bral. Dans ce cas, elles accroissent leur capacité à ...
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