Granulosa cell tumors
Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes
... Sandrine Caburet 1,2,6* , Mikko Anttonen 3,4 , Anne-Laure Todeschini 1,2 , Leila Unkila-Kallio 3 , Denis Mestivier 1,2 , Ralf Butzow 3,5 and Reiner A Veitia 1,2,6* Abstract Background: Ovarian granulosa ...
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A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors
... During the analysis of the AKT1 gene, the agarose gel electropho- resis of exon-3 PCR amplicons revealed the coexistence of two or three bands in 9 out of the 16 JGCT samples (Fig. 1A). One band had the expected length ...
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Effects of fibroblast growth factor 8 and 18 on ovine ovarian granulosa cell function
... inducing cell proliferation, angiogenesis, invasion, and ...induced cell growth, proliferation and potentiation of tumorigenesis using an independent ...of granulosa cells to FGF8 and FGF18 for 30 ...
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Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor
... Ovarian granulosa cell tumors (GCTs) are potentially malignant tumors that have a tendency for late recurrence and cause death in 80% of women with advanced GCT due to recurrent ...ovarian ...
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Impact de la lipotoxicité sur des cellules de la granulosa de femmes en processus de fécondation in vitro et chez des cellules surrénaliennes
... Le syndrome des ovaires polykystiques (SOPK) est un désordre endocrinien répandu chez les femmes en âge de procréer. Il est caractérisé notamment par une dysfonction ovarienne, un risque augmenté de développer une ...
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Analyse de l'expression génique dans les cellules de la granulosa de follicules dominants chez l'espèce bovine
... physiologiques chez la vache. La croissance du follicule dominant suivie de son développement au cours du stade ovulatoire résulterait de la variation du profil d’expression spatio-tempo[r] ...
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Proof of concept: prognostic value of the plasmatic concentration of circulating cell free DNA in desmoid tumors using ddPCR
... INTRODUCTION Desmoid tumors (DT) are rare mesenchymal neoplasms characterized by a high capacity to invade neighboring tissues. Albeit DT do not metastasize, this propensity to invasiveness may lead to iterative ...
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ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors
... We recommend screening for somatic and germline DICER1 pathogenic variants in all CNS embryonal tumors NOS, especially if they are LIN28A+, show chondroid differentiation, or are with any tumor of DICER1 syndrome ...
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Anti-Mullerian Hormone Recruits BMPR-IA in Immature Granulosa Cells
... Western blot Mouse primary GCs were seeded into 6 wells plates at a density of 5610 5 cells/well in 2ml of culture medium. Cells were then harvested, and lysed in 50 mM Tris HCL (pH 7.4)/150 mM NaCl, 1% protease ...
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Breast cancer: Do contaminants conspire with tumors?
... ESTROGENS MIGHT PROMOTE THE GROWTH OF BREAST HORMONE-DEPENDENT CANCER TUMORS. THIS INTERACTION MAY ALSO BE AFFECTED BY EX- TERNAL FACTORS WHICH CAN REDUCE OR ACCEN- TUATE THE HORMONES’ EFFECTS, BUT ONLY SOME ...
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Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
... critical cell–cell adhesion molecules, including claudins 3, 4, and 7, occludin, and ...E-cadherin. Tumors of this subtype are highly enriched in mesenchymal traits and stem cell features and ...
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Identification de gènes exprimés dans les cellules de la granulosa de follicules dominants chez l'espèce bovine
... De plus, l’expression différentielle des ARNm de LRP8, REELIN et MAPK8IP1 au cours de la croissance terminale du follicule suggère qu’une voie de signalisation REELTN/LRP$1MAPK8P1 pourra[r] ...
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Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors
... . Tumors are distinct from PDCL and usually cluster in two different ...genes, tumors clustered closely to their paired ...of cell cycle regulators, under-expression of immune-related pathways and ...
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Targeting a G-Protein-Coupled Receptor Overexpressed in Endocrine Tumors by Magnetic Nanoparticles To Induce Cell Death
... behaved similarly to cells having internalized CCK-DY647 (not illustrated). The impact of magnetic field treatment was deter- mined by counting cells labeled by FITC-tagged an- nexin V and/or propidium iodure, which ...
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Targeting a G-protein coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death
... inducing cell death upon exposure to an alternating magnetic ...by cell death. Moreover, first data on the mechanisms at the origin of cell death support the involvement of lysosomes and cysteine ...
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Deciphering the radiosensitivity of HPV-positive tumors
... 11. DNA polymerases Figure 1. Plasmid constructs used to integrate E6 and/or E7 into HPV negative cells via lentivirus (A). The two plasmid as well as the control plasmid express luciferase. List of cell lines ...
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Release of immunoreactive oxytocin and neurophysin I by cultured luteinizing bovine granulosa cells
... condition known to induce spontaneous luteinization of these cells. The production of immunoreactive OT was significantly higher in the cultures of granulosa cells harvested from large follicles than in those ...
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Defining sources of nutrient limitation for tumors
... cancer cell survival under very specific stress conditions or in particular ...cancer cell to survive the stresses associated with metastasis or chemotherapy treatment could be completely irrelevant to ...
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Improving diagnosis and management of primary brain tumors
... stem cell transplantation could be an alternative to whole brain radiotherapy cancer ...brain tumors, PCNSL is the tumor in which new therapeutic strategies appear most prom- ising in a near ...
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Gene Expression Profiling of Solitary Fibrous Tumors
... Fibrous Tumors Sixteen pre-treatment samples of pathologically confirmed SFT were available for RNA ...primary tumors (14 cases) and local relapses (2 ...
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