Granulosa cell
Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor
... Ovarian granulosa cell tumors (GCTs) are potentially malignant tumors that have a tendency for late recurrence and cause death in 80% of women with advanced GCT due to recurrent ...tumor cell ...
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Effects of fibroblast growth factor 8 and 18 on ovine ovarian granulosa cell function
... inducing cell proliferation, angiogenesis, invasion, and ...induced cell growth, proliferation and potentiation of tumorigenesis using an independent ...of granulosa cells to FGF8 and FGF18 for 30 ...
85
Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
... with granulosa cell dysfunction, and a representative BPES type II-causing variant (FOXL2-N109K), which is associated with normal ovarian function, to compare the molecular behavior of the FOXL2- C134W ...
11
Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes
... Sandrine Caburet 1,2,6* , Mikko Anttonen 3,4 , Anne-Laure Todeschini 1,2 , Leila Unkila-Kallio 3 , Denis Mestivier 1,2 , Ralf Butzow 3,5 and Reiner A Veitia 1,2,6* Abstract Background: Ovarian granulosa ...
12
A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors
... R201C and R201H of G αs in one third of the analyzed JGCTs. This muta- tion may lead to a constitutive activation of mitogenic FSHR signaling in the latter (Kalfa et al., 2006). FSHR signaling also activates the ...
12
Bisphenol S Impaired Human Granulosa Cell Steroidogenesis In Vitro
... underestimated, especially if the ovarian follicle reduces the BPSG levels that reach the follicular fluids. Future analysis will therefore combine assays performed in follicular fluid with assays performed in urine. ...
21
Detection of Minimal Levels of Serum Anti-Müllerian Hormone during Follow-Up of Patients with Ovarian Granulosa Cell Tumor by Means of a Highly Sensitive Enzyme-Linked Immunosorbent Assay.
... Spleen cell suspensions were fused with NS1 myeloma cells (four lym- phocytes/one NS1 cell) in the presence of polyethylene glycol 1000, according to Ko¨hler and Milstein ...
5
Differential regulation of early response genes by fibroblast growth factor (FGF) 8 and FGF18 in bovine granulosa cells in vitro
... Abstract Fibroblast growth factors (FGF) act as local regulators of follicular health and are known to increase granulosa cell (GC) proliferation, reduce apoptosis and decrease steroidogenesis. One ...
89
Caractérisation de la transcriptomique des cellules de la granulosa en fonction de la compétence ovocytaire chez le bovin
... of cell growth, proliferation and survival (Laplante and Sabatini, ...including granulosa cell growth and proliferation, steroidogenesis and the suppression of apoptosis (Balasubramanian et ...
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Identification and characterization of the transcriptional targets of the WNT/β-catenin signaling pathway in granulosa cells
... in granulosa cells in response to oxidative ...ovarian granulosa cells (48). The enzyme CYP19A1 is present in the granulosa cells of healthy growing antral follicles, and converts androgens to ...of ...
99
La régulation du gène CYP19A1 dans les cellules de granulosa bovine in vitro
... in granulosa cells (80% of all CYP19A1 transcripts detected in granulosa cells (Lenz et ...non-luteinizing cell is novel, and likely due to the presence of two putative CREs that differ from the ...
240
Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
... Cytokine Release Syndrome (CRS) CRS is a potentially fatal systemic inflammatory reaction that is observed after the infusion of immunotherapeutic agents (monoclonal Abs, BsAbs, and CARs). Although our understanding of ...
20
Correlation of cell membrane dynamics and cell motility
... cells. Cell segmentation is crucial to this work since tracking and subsequent analyses depend on the segmen- tation ...of cell is dependent on geometric centroid, cell shape has to be accurately ...
12
Cell interactions and cell signaling during hematopoietic development
... Conclusion. The cellular mechanisms by which hematopoietic (stem) cells are generated during embryonic development are quite well understood; however the molecular events that precisely control spatial and temporal ...
12
Cell-Intrinsic and cell-extrinsic resistance to classical chemotherapies
... A third challenge to changing the current standard of care is the poor efficacy of current treatments. When chemotherapy use first began, cancer was invariably a death sentence. Due to that fact, and differences in the ...
121
Cell Wall
... The reliability of protein profiling for a compartment like the cell wall strongly depends on the quality of the extraction protocol. The classical methods to check the purity of a particular fraction are not ...
17
Cell fractionation
... EDTA. Sucrose makes the medium hypertonic while EDTA chelates divalent cations and destabilises the outer membrane. Then, lysozyme is added to cleave the periplasmic peptidoglycan layer. However, peptidoglycan hydrolysis ...
8
Cell labeling with magnetic nanoparticles: Opportunity for magnetic cell imaging and cell manipulation
... for cell vectorization, we can proceed to magnetic targeting in vivo (Figure ...If cell aggregates are injected intravenously, they will block the vessels (especially the small pulmonary ones) and the ...
20
Intestinal epithelial cells instruct myeloid cell-mediated T-cell responses
... Treg cell homeostasis in the large ...Treg cell frequency in the gut. Most notably, the cell type-specific ablation of IL-1-dependent signaling in ILC abrogates oral tolerance to dietary antigens and ...
85
Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
... Finally, over the last few years it has been found that CypA and CD147 are overexpressed in several cancers 123, 124, 166, 167 , suggesting that they may support growth in other cell types as well. 5.4 Summary In ...
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