glutamate receptor
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Pharmacodynamics of the Glutamate Receptor Antagonists in the Rat Barrel Cortex
... applied glutamate receptor antagonists was comparable with bath application in vitro only in superficial L2/3, in deeper layers the inhibitory effects developed much slower following a surface-to-depth ...
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
... Abstract Whereas agonists bind directly in the heptahelical domain (HD) of most class-I rhodopsin-like G-protein coupled receptors (GPCRs), class-III agonists bind in the extracellular domain of their receptors. Indeed, ...
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Activation of a Dimeric Metabotropic Glutamate Receptor by Inter-Subunit Rearrangement
... metabotropic glutamate receptor (mGluR) as a ...Moreover, glutamate and its analogues do not bind to the TMD of an mGluR, but to a distinct extracellular domain called Venus Flytrap (VFT) ...
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Metabotropic glutamate receptor 5 in bulimia nervosa
... Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities ...
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Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
... A recent study revealed that mGlu2-4 heterodimers are likely present in cortico striatal terminals ( Yin et al., 2014 ). This conclusion is based on co-immunoprecipitation data, and on the lack of effect of PHCCC, an ...
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Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7.
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Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.
... the receptor preceded by a signal peptide sequence derived from ...GABAb receptor GB1a or GB2 subunits followed by the carboxyl-termini of mGluR1a or mGluR1b variants were done using unique Sph1 site on ...
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The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging
... In contrast, there is considerable evidence for a stimulatory autocrine feedback loop of glutamate in a -cells [ 4 , 18 , 20 ]. The obvious question is whether GluK2 may be speci fically implicated. As a -cells ...
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The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging
... In contrast, there is considerable evidence for a stimulatory autocrine feedback loop of glutamate in a -cells [ 4 , 18 , 20 ]. The obvious question is whether GluK2 may be speci fically implicated. As a -cells ...
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
... vesicular glutamate transporter 3 ...mGlu4 receptor staining (⬍10%) merged with peptidergic and nonpep- tidergic C fibers markers, such as substance P (SP), calcitonin gene-related peptide (CGRP), or ...
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Metabotropic glutamate receptor 5 in bulimia nervosa
... Positive t-values indicate higher mean [11C]ABP688 DVR in subjects receiving antidepressant treatment than in subjects not receiving antidepressant medication.. All three subjects with[r] ...
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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
... Supplemental figure 6: Molecular determinants of mGlu3 chloride lock A. Sequence alignment of the 8 mGluRs performed using Align123 on Discovery Studio suite and then optimized. Sequences were retrieved from Uniprot ...
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Optocontrol of glutamate receptor activity by single side-chain photoisomerization
... control receptor activity with light The activation of NMDARs requires binding of two different agonists, glutamate and glycine (or D-serine), a unique feature among ligand-gated ion ...GluN1/GluN2 ...
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
... vesicular glutamate transporter 3 ...mGlu4 receptor staining (⬍10%) merged with peptidergic and nonpep- tidergic C fibers markers, such as substance P (SP), calcitonin gene-related peptide (CGRP), or ...
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A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis
... metabotropic glutamate receptors (Matosin and Newell, 2013) and modulators of the N-methyl-D-aspartate receptor (NMDAR) including D- serine or glycine in add-on in chronic schizophrenia (Kantrowitz et ...
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AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.
... + glutamate decreased the glutamate-induced inward current in 43% of the tested neurones (3/7) with a maximum average decrease of ...all glutamate receptor subtypes were activated by ...
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Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
... To isolate GluN2A NMDAR EPSCs, neurons were held at −60 mV in the presence of NBQX (10 μM), picrotoxin (50 μM), Mg 2+ (0.5 mM), and piperindine 18 (1 μM; selective GluN2B-NMDAR antagonist). All drugs were applied in the ...
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Rôles physiologiques du transporteur vésiculaire du glutamate VGLUT2 dans les neurones dopaminergiques
... and glutamate, suggesting that most terminals have the capacity to release both transmitters 60 (see also 62, 65 for early ultrastructural data suggesting that DA neurons establish two morphologically distinct ...
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en fr Paracrine transmitters as informative signals: GABA and glutamate modulate neuronal migration Modulation de la migration neuronale par les neurotransmetteurs GABA et glutamate : aspects fondamentaux et implications pathologiques
... Paracrine transmitters as developmental signals An increasing amount of evidences, including those provided in our study, suggest that transmitters act as developmental signals (Nguyen et al., 2001;Owens and Kriegstein, ...
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The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
... developmental defects, such as impaired node formation and gastrulation (Pare et al., 2004). During adulthood, LRH-1 plays important roles in cholesterol and lipid homeostasis by controlling the expression of genes ...
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