follicular regulatory T cells
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
... B cells that have point mutations introduced into the Ag-binding regions of their B-cell receptor genes by the process of somatic hypermuta- ...B cells are then subjected to selection, and often further ...
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Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches
... and regulatory (TFR) cells are critical players in managing ger- minal center (GC) reactions that accomplish effective humoral immune ...TFR cells iso- lated from Peyer’s Patches (PP) and immunized ...
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T follicular helper and T follicular regulatory cells have different TCR specificity
... Tfh cells. (a) Frequency of follicular CD4 þ CXCR5 þ PD-1 þ T cells on popliteal LNs of 1D2b mice before (left), and 11 days after OVA-IFA immunization (middle), when both Tfr and Tfh cells ...
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Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
... Tfr CellS, OTHeR GC ReGUlaTORS Tfr Cell Development and antigen- Specificity Regulatory T cells form the main population of immunosup- pressive T cells that plays a pivotal role in maintaining ...
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Regulatory myeloid cells: an underexplored continent in B-cell lymphomas
... (DLBCL), follicular lymphoma (FL), and classical Hodgkin lymphoma (HL) represent 60% to 70% of B-cell lymphoma ...on cells in the TME [3]. For example, more than 90% of the cells in HL tumors are ...
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B cells with regulatory properties in transplantation tolerance
... plasma cells, it decreases antibody production [18] ...B cells, to inhibit B cell activation and proliferation leading to a beneficial effect for treatment of systemic lupus erythematosus [20] ...B ...
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Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma
... Treg cells are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral ...These cells regulate a diverse array of immune responses in the context of ...
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Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
... presented by LNSCs in the context of MHC class II molecules. In accordance with these findings, low levels of MHC class II, compared to expression levels on DCs, were detected on all LNSC subsets when freshly isolated, ...
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HIV triggers immunoregulatory dendritic cells and regulatory T cells through the non-canonical NF-kB pathway
... Methods The cells used were purified primary pDC and the GEN pDC cell line. A combination of siRNA knock-down, immunoprecipitation of TLR signaling pathway molecules, IDO promoter engineering and chromatin ...
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Expansion of regulatory T cells in patients with Langerhans cell histiocytosis.
... report [35], RANKL appeared to be expressed by small lymphocytes rather than LCH cells (Figure 4F). Ki-67 protein was detected in the nuclei of FoxP3 þ T cells, suggesting that they were proliferating ...
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Pertussis Toxin Reduces the Number of Splenic Foxp3 + Regulatory T Cells
... symbols) or PBS-treated (white symbols) mice. Unstimulated proliferation was minimal, ranging from 13 to 35 cpm. These experiments are repre- sentative of four independently performed experiments. C, Expression of IFN- ...
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BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
... All cells that were located outside the main cluster were considered low quality and removed from further ...visualize cells in a reduced dimensionality, PCA was performed on the most variable genes, which ...
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Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry
... Figure 1. Single-cell analysis platform for interrogation of human myeloid cell polarization phenotypes. (a) Patient-derived tissue (human blood or bone marrow) can be single-cell dissociated and cultured in a variety ...
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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
... (i) Cell surface and intracellular markers A number of phenotypic markers help to define the Treg cel- lular phenotype and specificity and are associated with distinct expression levels of surface and intracellular ...
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Study of the cellular prion protein expression by the follicular dendritic cells in ovine pharyngeal tonsils.
... Study of the cellular prion protein expression by the follicular dendritic cells in ovine pharyngeal tonsils. Vinciane Toppets ¹, Joelle Piret ¹, Valerie Defaweux ², Frederic Lantier 3 , Patricia Berthon 3 ...
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Role of regulatory T cells in the pathogenesis of HIV-1 infection
... Treg cells fine-tune the memory/ effector cell balance and promote the accumulation of long-living memory cells in case of strong ...T cells after activation (Nikolova et al, ...
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Regulatory cells and immunosuppressive cytokines: parasite-derived factors induce immune polarization.
... presenting cells and regulatory T cells (Treg ...the cells of the innate immunity leading to such polarized cytokine secretion has been reported [ 1 , 2 ...
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Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps
... sorted cells was stained for intracellular FoxP3 expression using anti-hFoxP3 (-Alexa ...on cells that were fixed and permeabilized using FoxP3 staining buffer set (BD Pharmingen™), according to the ...
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No lack of regulatory B cells in patients with Multiple Sclerosis
... B cells in MS ...B cells secreting IL-10 negatively regulate disease symptoms in Experimental Autoimmune Encephalomyelitis ...such regulatory B cells in MS remains ...
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Cyanoacrylate skin surface / follicular stripping.
... 22.2 Cyanoacrylate Skin Surface and Follicular Stripping Cyanoacrylate skin surface stripping (CSSS) is a time-honoured method [ 1 ]. The method came into existence when high bond glues became available. After ...
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