Follicular helper T cell
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas
... genes as CD28, FYN, PLCG1, or CARD11 have also been reported in several PTCLs. 12,20-25 However, alterations in the TCR signaling pathway have not yet been extensively studied in TFH-related lymphomas. Here, we focused ...
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HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
... B cell maturation and ...B cell differentiation. This skewed B cell dif- ferentiation might strongly impact the capacity of the immune system to generate ...
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Tissue Infiltrating LTi—Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis
... B cell subsets [BM1-BM2: naïve B cells; BM2’: germinal center founder B cells; BM3-BM4: germinal center B cells (centroblast—centrocyte); BM5: memory B cells; eBM5: early memory B cells] in the thyroid of a ...
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Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches
... the cell unresponsive to CXCR4 triggered ...promotes cell migration via the CXCR4/CXCL12 axis was downregulated in TFH ...TH17 cell differentiation ( 33 ) and its downregulation might influ- ence ...
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HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells
... Tfh cell intermediate ( 1 ), accompanied by the upregulation of PD-1 and downregu- lation of CCR7 ( 2 ...Tfh cell commitment, as initial Tfh cell phenotypes obtained at the DC priming stage are lost ...
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T follicular helper and T follicular regulatory cells have different TCR specificity
... of follicular CD4 þ CXCR5 þ PD-1 þ T cells on popliteal LNs of 1D2b mice before (left), and 11 days after OVA-IFA immunization (middle), when both Tfr and Tfh cells are present ...control). Cell ...
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Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse
... Keywords: follicular lymphoma; B cells; Tfh; mesenchymal stromal cells ...B cell selection and differentiation into high-affinity antibody-secreting cells [ 1 , 2 ...B cell and a pre-activated CD4 ...
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Definition of B cell helper T cells in rheumatoid arthritis and their behavior during treatment
... B cell deficiency result in arthritis development impairment after immunization with proteoglycan ...B cell involvement in RA pathogenesis is efficiency of B cell depletion therapy ...+ helper ...
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Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
... B cell helper function. These molecules include protein cell death 1 (PD-1), B and T lymphocyte attenuator, CD40L, ICOS, SAP, and the production of IL-21 and IL-4 ( 2 ...B cell isotype switch ...
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Lymphocytes T folliculaires helper et VIH - Unis pour le meilleur et pour le pire
... regulatory cell ; LT : lymphocyte T ; Tbet : T-box transcrip- tion factor ; Tfh : T follicular helper cell ; TGF : transforming growth factor ; Th : T helper ; TNF : tumor necrosis ...
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Combination lenalidomide-rituximab immunotherapy activates anti-tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma
... T-helper cell type 1 (Th1) cytokine ...NK cell immunological synapses with primary FL tumour cells, the combination was superior and correlated with enhanced ...
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Follicular helper T cells: implications in neoplastic hematopathology.
... FH cell functions while interacting with B cells rather than they constitute a distinct ...all follicular T cells are B-cell helper cells as some follicular T cells appear to have a ...
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Interconnected subsets of memory follicular helper T cells have different effector functions
... memory cell compartments perceiving this interaction as memory sustaining, as opposed to an immune challenge resulting in activation and effector out- ...Tfh cell populations 58 ...B cell ...
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en fr Follicular helper T cells and HIV - United for better and worse Lymphocytes T folliculaires helper et VIH : Unis pour le meilleur et pour le pire
... B cell receptor ; CG : centre germinatif ; CMH : complexe majeur d’histocompatibilité ; DC : cellule dendritique ; IL : interleukin ; LB : lymphocyte B ; TCR : T cell receptor, Tfh : T follicular ...
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CD4 T-Helper Responses to the Anaplastic Lymphoma Kinase (ALK) Protein in Patients with ALK-Positive Anaplastic Large-Cell Lymphoma
... 1 Nuffield Department of Clinical Laboratory Sciences, Leukemia Research Fund Immunodiagnostics Unit, John Radcliffe Hospital, and 2 Transplant Immunology, Oxford Transplant Center, Churchill Hospital, Oxford, United ...
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Stromal cell contribution to human follicular lymphoma pathogenesis.
... B cell apoptosis ( Sacedon et ...of cell-autonomous activation of Hh pathway in DLBCL com- pared to FL, likely contributes to stroma-independence in this aggressive disease ( Kim et ...B cell growth ...
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Multi-view Sequential Games: The Helper-Agent Problem
... 5. CONCLUSION AND FUTURE WORK We introduced a framework for AI-helper agents. This re- lies on the premise that an AI will be useful for tasks where it could perform better than humans, due to its superior ...
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Cell-free DNA in Human Follicular Microenvironment: New Prognostic Biomarker to Predict in vitro Fertilization Outcomes
... with follicular maturity abnormalities, such as increased number of small pre-antral follicles [ 8 , 36 ...case follicular fluids from smaller follicles would become proportionally more represented in the ...
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The yin and the yang of follicular lymphoma cell niches: Role of microenvironment heterogeneity and plasticity.
... human cell engraftment in NOD-based immunodeficient mouse models is a Sirpa gene polymorphism allowing recognition of human CD47 by mouse phagocytes and inhibiting human grafted cell engulfment ...
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Etude de l'interaction entre les mastocytes et les lymphocytes T helper
... Stem cell factor and interleukin-4 induce murine bone marrow cells to develop into mast cells with connective tissue type characteristics in vitro.. Substance P and ot[r] ...
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