fibroblast growth factor receptor (FGFR)
The Effect of Activating Fibroblast Growth Factor Receptor 3 Mutations on Osteogenic Differentiation and Ectopic Bone Formation by Human Periosteal Derived Cells
... the Fibroblast Growth Factor (FGF) receptor 3 (FGFR3) signalling pathway in endochondral bone development, and more specifically in the regulation of chondrocyte proliferation and ...
5
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)
... kinase receptor for members of the fibroblast growth factor family, and a gene from 13q12, tentatively named FIM (Fused In Myeloproliferative ...
7
Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production
... biochemical fractionation and light microscopy. Therefore, it is tempting to speculate that intracellular trafficking of DENV parti- cles is altered upon FGFR signaling inhibition. Consistently, less immature virions ...
21
Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk
... Cadherins are the homophilic ligands of Adherens Junctions (AJ) involved in the cohesion of solid tissues 47 . Cadherins provide anchorage between neighbouring cells thanks to their interaction with the contractile ...
59
Neuroprotection and regeneration of adult lesioned retinal ganglion cells by the modulation of fibroblast growth factor-2 and receptor tyrosine phosphatase-sigma
... Thirteen days afier nerve injury, RGC axons were anterogradely Iabeled by 10 injection of CTf3 and, 24 hrs later (2 weeks post-rnicrocrush lesion), animais were sacrificed and the optic [r] ...
404
Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats.
... several growth fac- tors in lung inflammation and repair has been extensively in- ...protective growth factors to the alveolar epithelium improves ALI in experimental models, but the potential effects of ...
13
Differential regulation of early response genes by fibroblast growth factor (FGF) 8 and FGF18 in bovine granulosa cells in vitro
... all receptor proteins, whereas FGF2 activates only the “c” splice variants of FGFR1, FGFR2 and FGFR3 as well as ...FGFR4. Receptor activation pattern tends to be similar within FGF subfamilies, for example, ...
89
Carboxy-terminal fragment of fibroblast growth factor 23 induces heart hypertrophy in sickle cell disease
... Our results indicate that a cleaved form of FGF23 is released in the blood of SCD patients and demonstrate for the first time that cFGF23 can induce cardiac hypertrophy via activation of a FGF receptor and may ...
12
Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site.
... paradoxical consequences of diabetes, retinal angiogenesis versus limb ischemia. In the simplified model based on our data (Fig. 5), we propose that IRES-dependent regulation of translation is an important parameter in ...
32
Altered expression of type I insulin-like growth factor receptor in Crohn's disease
... CD: fibroblast-fike cells in the fibrosed submucosa, adipocytes in fibrolipomatous tissue wrapping the intestine, also in the fibrosed area, and nerve cells in hypertrophic ...
9
Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation
... endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by ...basic fibroblast growth ...
9
Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor
... Platelet-Derived Growth Factor (PDGF) and its Receptors Platelet-derived growth factors are homo- and hetero-dimeric proteins secreted by platelets and many other cell types, including fibroblasts, ...
138
Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism.
... Coordinated activation of IRES with the corresponding promoter in conditions of cap-dependent translation blockade has been reported for the Drosophila insulin- like receptor, underlining the key role of IRESs in ...
13
Mapping of the fibroblast growth factors in human white adipose tissue.
... ibroblast growth factor receptor 1 (FGFR1) is acti- vated by several fibroblast growth factors, and pre- vious studies suggest a role for FGFR1 signaling in the regulation of energy ...
6
Disease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
... evidence showed a doubtful patient outcome, physicians chose treatment options based on their clinical depart- ment procedures. Another emerging factor in the interpretation of guide- lines is the use of targeted ...
10
Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.
... Figure 1 Expression of the insulin Receptor (INSR) on human myeloma cell lines (A) Cell surface expression of INSR was determined by flow cytometry using PEconjugated anti-INSR mAb. The black histograms show the ...
15
Modulating antibody-dependent cellular cytotoxicity of epidermal growth factor receptor-specific heavy-chain antibodies through hinge engineering
... In the case of one chimeric HCAb (EG2-hFc), we found that variants bearing longer hinges (IgG3 or camelid hinge regions) showed dramatically improved ADCC in comparison with a variant be[r] ...
13
Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA.
... but not hnRNP C1/C2, mRNAs are loaded on polysomes in a growth-dependent manner (40). As a consequence, the intracellular levels of hnRNP A1 would increase very rapidly after a proliferation stimulus. Indeed, the ...
46
Eye-derived fibroblast growth factors: receptors and early events studies
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
4
Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation
... Introduction GBMs are classified on the basis of histopathological features, clinical presentation and molecular characteristics (reviewed in (1, 2)). The hallmark features of GBM are uncontrolled cellular ...
19