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Experimental autoimmune myasthenia gravis

Decreased expression of miR-29 family associated with autoimmune myasthenia gravis

Decreased expression of miR-29 family associated with autoimmune myasthenia gravis

... Keywords: microRNAs, DICER, Thymus, Thymic epithelial cells, Experimental autoimmune myasthenia gravis, Interferon- β, Th17 cells, BAFF © The Author(s). 2020 Open Access This article is ...

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A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

... Isabelle Bernard, Antoine Sacquin, Sahar Kassem, Mehdi Benamar, Céline Colacios, Mylène Gador, Corine Pérals, Nicolas Fazilleau and Abdelhadi Saoudi* Centre de Physiopathologie de Toulouse Purpan, Université de Toulouse, ...

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Muscle satellite cells are functionally impaired in myasthenia gravis: consequences on muscle regeneration

Muscle satellite cells are functionally impaired in myasthenia gravis: consequences on muscle regeneration

... Abstract Myasthenia gravis (MG) is a neuromuscular disease caused in most cases by anti-acetyl-choline receptor (AChR) autoantibodies that impair neuromuscular signal transmission and affect skeletal muscle ...

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Review on Toll-Like Receptor Activation in Myasthenia Gravis: Application to the Development of New Experimental Models

Review on Toll-Like Receptor Activation in Myasthenia Gravis: Application to the Development of New Experimental Models

... many autoimmune experimental models, the use of CFA is mandatory to set up these disease models and MTB is critical in the activation of innate immune signaling pathways leading to the sensitization against ...

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Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models

Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models

... France Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular ...an experimental MG model associated with ...

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Regulatory B cells in myasthenia gravis are differentially affected by therapies

Regulatory B cells in myasthenia gravis are differentially affected by therapies

... Conclusion The decrease of peripheral Breg cells in MG patients need to be further defined. Is the decrease involved in the initi- ation of the disease leading to inflammation, or is it a consequence of the ongoing ...

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Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis

Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis

... Acquired Myasthenia Gravis (MG) is a neurological disease mainly caused by autoantibodies against the acetylcholine receptor (AChR) [11] leading to muscle disabling ...prototype autoimmune disease ...

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Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

... Autoreactive Tregs are more efficient at controlling organ-specific autoimmune diseases than polyclonal Tregs and have therefore at- tracted a lot of attention [ 20 , 50 ]. Strategies have been developed to either ...

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Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance

Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance

... for autoimmune diseases acting at the level of the peptide:MHC/TCR complex is glatiramer acetate (GA) for the treatment of multiple sclerosis ...ameliorate experimental autoimmune encephalomyelitis ...

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VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage

VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage

... useful experimental ap- proach as it bypasses the initial phase in which endogen- ous T cells are exposed to the autoantigen, by injecting cells from immunized mice that have been reactivated in vitro ...

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White matter reactive astrocytes express nuclear estrogen receptor alpha (ESR1) in experimental
autoimmune encephalomyelitis and multiple sclerosis.

White matter reactive astrocytes express nuclear estrogen receptor alpha (ESR1) in experimental autoimmune encephalomyelitis and multiple sclerosis.

... The mechanism of action of estrogens as modulators of inflammation and neuroprotection in neurodegenerative disorders is a matter of great debate. Whereas an active astrocytic involvement in the physiopathology of ...

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IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis

IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis

... libitum. Experimental proce- dures and protocols were performed according to the US National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publication ...

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Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis

Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis

... animal experimental procedures were ap- proved by the Animal Ethics Committee of the CEA, by the French General Directorate for Research and Innovation (project ...

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Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis

Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis

... in over 60% of the treated mice 619 . On the other hand, depletion with the use of anti-CD22 Abs leads to a partial removal of B cells since it is not expressed on immature B cells. In NOD mice, it can significantly ...

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The Nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

The Nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

... organ-specific autoimmune disease resulting in demyelinating plaques throughout the central nervous ...used Experimental Autoimmune Encephalomyelitis (EAE), a well- characterized mouse model of ...

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Autoimmune and inflammatory diseases following COVID-19

Autoimmune and inflammatory diseases following COVID-19

... or autoimmune responses is associated with a particular variant of SARS-CoV-2 (Box 1 ...of autoimmune and autoinflammatory conditions in SARS-CoV-2-infected populations are mostly responsive to intravenous ...

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Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis

Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis

... One of the major mechanisms responsible for the reg- ulation of immune responses and immune homeostasis is peripheral tolerance induction through the action of CD4 + regulatory T cells (Tregs) [ 4 ]. Tregs are critical ...

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Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

... human autoimmune demyelinating diseases (ADD), which is frequently used for the induction of experimental autoimmune encephalomyelitis (EAE) in ...

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Étude de la cytolyse autologue et du mimétisme immunitaire dans l'hépatite autoimmune de type 2

Étude de la cytolyse autologue et du mimétisme immunitaire dans l'hépatite autoimmune de type 2

... Nous avons toutefois voulu effectuer un test de cytotoxicité utilisant, en plus des cibles utilisées précédemment, les cellules B transfectées comme huitième cible, étape 3 du projet (Fi[r] ...

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Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy

Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy

... extra-intestinal autoimmune diseases, two had antibodies react- ing with the 75 kilodalton antigen characteristic of AIE and one had serum anti-goblet cell ...

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