Estrogen receptor-positive
A phase II study of afatinib, an irreversible ErbB family blocker, added to letrozole in patients with estrogen receptor-positive hormone-refractory metastatic breast cancer progressing on letrozole
... Katharina Gunzer 1* , Florence Joly 1,2 , Jean‑Marc Ferrero 3 , Joseph Gligorov 4,5 , Helene de Mont‑Serrat 6 , Martina Uttenreuther‑Fischer 7 , Katy Pelling 8 , Sven Wind 7 , Guilhem Bousquet 9 and Jean‑Louis Misset 9 ...
13
Progesterone receptor, obesity and prognosis in women diagnosed with estrogen receptor positive breast cancer
... 19 Summary The evidence to support the presence or absence of an association is rather weak for several molecular subtypes due to the single study, the positive but not significative associations or half of the ...
79
Resistance to therapy in estrogen receptor positive and human epidermal growth factor 2 positive breast cancers: progress with latest therapeutic strategies.
... et al. 2014]. In more heavily pretreated patients, the addition of everolimus to vinorelbine and trastuzumab resulted only in improved outcome in the ER-negative subpopulation during a hypothesis-generating analysis. The ...
21
Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer
... subset, high MAGI1 expression associates with ESR1 and luminal genes GATA3 and FOXA1 expression and better prognosis, while low MAGI1 levels correlates with higher histological grade, more aggressive phenotype and worse ...
23
Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior
... We believe that the cytotoxicity of the ferrocifen SERMs toward the ERβ-positive breast cancer cell line is due to the production of radical species in situ, following the preliminary oxidation of Fe(II) to ...
23
Plasma estrogen levels, estrogen receptor gene variation, and ischemic arterial disease in postmenopausal women: the three-city prospective cohort study.
... cardiovascular risk factors and correction for multiple testing. We also investigated the role of haemostatis and inflammation as potential mediators. Results: Neither estradiol nor IAD risk were significantly associated ...
30
Selective estrogen-receptor modulators (SERMs) in the cyclopentadienylrhenium tricarbonyl series: Synthesis and biological behaviour
... the receptor binding site, and to add a functional or potentially functional group to tamoxifen, in this case an organometallic function, that might lead to an increased range of ...
37
Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.
... by receptor status because assessment of ER status probably referred only to the expression of ERα and not ERβ, which is the subtype of ER that phytoestrogens preferentially bind ...the receptor expressed ...
18
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
... computationally removed using a filter-based method 56 . In the analysis of primary tumors that are formalin-fixed, paraffin-embedded samples [FFPE] we further applied a filter to remove FFPE-related artifacts 57 ...
42
Estrogen receptor gene variants are associated with anxiety disorders in older women.
... endogenous estrogen levels, we also investigated whether the use of estrogen-containing hormone treatment (HT) could modify the association between ER variants and ...
18
Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants.
... All brain measures are given as a percentage of total intracranial volume (ICV), except for the volume of white matter lesions, which were adjusted for the volume of white matter.. Adju[r] ...
12
Effects of Bisphenol A and Diethylstilbestrol on Estrogen Receptor Expression and Male Fertility
... Of the 20 studies included in the systematic review, only 1 was inconclusive. Hong et al. (2010) demonstrated effects of DES on gene expression, but did not provide insight into the injurious effects, or lack thereof, on ...
8
The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
... In our study, we also analyzed the ability of the two iso- forms to bind cofactors using the MARCoNI assay, and found that the two isoforms show some heterogeneity in terms of binding to coregulators. The ability of the ...
17
Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.
... endothelial progenitor cells (EPC) could also have contributed to the formation of tumor endothelium, but it remains highly controversial (29). In the present work, E2 elicited similar pro-tumoral effects in chimeric ...
32
Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.
... 15. Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL, Hanna WM, Langer A, McShane LM, Paik S, Pegram MD, Perez EA, Press MF, Rhodes A, Sturgeon C, Taube SE, Tubbs R, Vance GH, ...
12
A bifunctional platinum(II) antitumor agent that forms DNA adducts with affinity for the estrogen receptor
... Earlier work from our laboratory [12,13] resulted in the synthesis of compounds in which DNA- interactive nitrogen mustards were tethered to ligands for steroid receptors (either the androgen or the estrogen ...
17
Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor.
... Thrombin receptor, Macmarcks, CTGF), cell adhesion (Integrin α 3 chain, integrin β 1 subunit), stress response (HSP60, Glutathione reductase, Glutathione peroxidase), DNA synthesis and repair (TopoII α , HHR23A, ...
16
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells.
... Ariane Freund, Corine Chauveau, Jean-Paul Brouillet, Annick Lucas, Matthieu Lacroix, Anne Licznar, Françoise Vignon, Gwendal Lazennec. To cite this version:[r] ...
8
Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
33
Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
4