embryonic stem cell
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.
... germ cell tumors by targeting the cell cycle inhibitor LATS2 ...this embryonic stem cell miRNA cluster shares some similarities with two miRNA clusters recently found to be ...
17
Mind the Gap : Policy Approaches to Embryonic Stem Cell and Cloning Research in 50 Countries
... cloning, and stem cell research. Those traditions, values and interests “operate symbiotically in the crafting of legislative parameters for stem cell and cloning science.” 30 Within this ...
18
Control of the Embryonic Stem Cell State
... of embryonic stem cell state in terms of global gene regulation, which serves as both a baseline for under- standing the changes that occur as cells differentiate and develop and as a means to ...
16
Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.: cardiac MR and pacemaker channel HCN1
... Mineralocor- ticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.: cardiac MR and pacemaker channel HCN1... Abstract.[r] ...
39
Diverging against all odds? Regulatory Paths in Embryonic Stem Cell Research across Western Europe
... For Peer Review Only INTRODUCTION 1 Since the early stages in the development of human biotechnology, the differences in regulations across Western Europe intrigued and puzzled comparative public policy scholars. ...
41
Murine Embryonic Stem Cell Plasticity Is Regulated through Klf5 and Maintained by Metalloproteinase MMP1 and Hypoxia
... Mouse embryonic stem cells (mESCs) are expanded and maintained pluripotent in vitro in the presence of leukemia inhibitory factor (LIF), an IL6 cytokine family member which dis- plays pleiotropic functions, ...
21
Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal
... of embryonic stem cells (ESCs) has been extensively studied since the cells’ isolation, but the necessity for cell-secreted factors in self-renewal has remained undefined to ...deplete cell- ...
7
A panel of embryonic stem cell lines reveals the variety and dynamic of pluripotent states in rabbits
... murine embryonic fibroblasts ...All cell lines that survived beyond passage 10 after dissoci- ating the primary outgrowth sustained long-term ...if cell lines could be cultured beyond passage ...
17
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET
... Background Embryonic stem (ES) cells are derived from the inner cell mass of the embryo and possess the property of pluripotency, which is the ability to develop into any cell lineage of the ...
15
Derivation and cloning of a novel rhesus embryonic stem cell line stably expressing tau-green fluorescent protein.
... Finally, we investigated the behaviour of tau-GFP LYON-ES derived precursors in vivo , upon transplantation into the adult rat brain. Tau-GFP LYON-ES cells were induced to differentiate into neural precursors, that were ...
14
Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration
... pluripotent stem cell (PSC)-based reparative cell therapies are reaching the bed- side, there is a growing need for the standardization of studies concerning safety of the derived ...human ...
19
Establishing a Robust In Vitro Embryonic Stem Cell Differentiation Assay to Monitor the Hematopoietic Potential of DELES Clones
... mesenchymal stem cells (MSCs) that play an important part in the bone marrow ...hematopoietic stem and progenitor cells (HSPCs) with the extra-cellular molecules and soluble factors that are essential for ...
87
A 3D magnetic tissue stretcher for remote mechanical control of embryonic stem cell differentiation
... organize stem cells (only) into a 3D tissue structure that can be stimulated at will, in order to explore the physical differentiation approaches in 3D purely cellular ...3D cell assembly, one needs to ...
13
Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors.
... clonal cell line control (HCT116) which, after transduction with a GFP lentivirus, contained one lentiviral integration per cell (see Add- itional file 3: Figure ...
17
Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold
... ventricular function was assessed by echocardiography at baseline and every month thereafter until 4 months. Hearts were then processed for the assessment of fibrosis and angiogenesis and a 5- component heart failure ...
31
Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation
... (AP) 6 days later. SETa and SETb overexpression increased colony numbers by 2.3-fold and 1.7-fold, respectively ( Figures 3 H and 3I), indicating that SET can impart survival advantage, consistent with its effect on ...
14
The cell-secreted microenvironment : shaping embryonic stem cell self-renewal and differentiation
... important cell signaling proteins are presented from within the extracellular matrix, both in vivo and in ...the cell (Kuhl and Griffith-Cima, ...affects stem cell properties and how signals ...
146
Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro
... germ cell lineage [ 11 ...pluripotent cell lines that are virtually indistinguishable from ESCs [ 12, 13 ], and among all lineages that develop from epiblast, only germ cells regain expression of ...
8
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
... Cripto deficiency attenuates ESC lineage restriction. Our findings that Cripto is required for ESC-EpiSC transition leave open the question of the fate of F/A-induced Cripto KO ESCs. To address this issue, we first analysed ...
17
Embryonic stem cell markers expression in cancers.
... DeBiasi, L. Spinardi, A. Ronchi, E. Wanke, S. Brunelli, R. Favaro, S. Ottolenghi, and S.K. Nicolis, Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants. Development 135 (2008) ...
23