effector CD8+ T cells
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
... − CD8 + TILs in E8i-Cre + Tcf7 fl/fl mice (Figure ...T cells was decreased within the memory-precursor-like subset, shifting the balance towards the effector-like subset of PD-1 − CD8 + TILs ...
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus
... NK cells can dramatically decrease the intensity and duration of pDC activation by controlling viral burden, which prevents the production of very high systemic levels of IFN-a/b, and eventually other innate ...
14
Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria in the mouse
... memory cells were able to join effector clusters in absence of a specific TCR trigger, we also co-stained these sections for CD8 expression and delineated 3 regions of interest: the entire splenic ...
15
Role of the Wiskott-Aldrich syndrome protein in human CD8+ T cell activation and effector function
... revertant cells have been shown to regain ...T cells displayed normal morphology and microvilli numbers 175 ...T cells displayed normal subcellular localization of WASP, proliferation and cytokine ...
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en fr Characterization of memory CD8+ T cells generated in sterile inflammatory conditions Caractérisation des lymphocytes T CD8+ générés en conditions inflammatoires stériles
... memory CD8 T cells generated in a sterile inflammatory context is the CHS reaction to the hapten 2,4-dinitrofluorobenzene (DNFB), a widely used model of DTH in which the immune response is mediated by ...
175
Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell–Effector Responses
... SF9 cells (gift from ...Five cells (gift from ...Benzonase. Cells were then sonicated and centrifuged for 15 minutes at 10,000xg, leaving protein inclusion ...
29
Contrasted TCRβ diversity of CD8+ and CD8- T cells in rainbow trout
... and effector memory T cells persist in the memory pool to provide systemic immune surveillance in secondary lymphoid and in non-lymphoid tissues, to react promptly in case of secondary ...infection. ...
13
Interconnected subsets of memory follicular helper T cells have different effector functions
... B cells can be found in the memory ...Tfh cells in proximity to memory B cells in the B follicles of the lymphoid site draining initial Ag entry with the two memory cell compartments perceiving this ...
15
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection
... Global transcriptional repression in T2/late HCV-speci fic CD8+ T cells. To delineate the dysfunctional features of the T2/late-chronic stage, we focused on the comparison between HCV-specific CD8+ T ...
21
Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection
... CTL effector functions, it has long been considered that neurons were spared from CD8 T cell attack because they did not express MHC I molecules ...B-containing CD8 T cells in direct ...
15
CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
... T cells that do not express either CD4 or CD8 co-receptor provided proof-of-concept for MHC-independent modes of T cell activation (Porcelli et ...(iNKT) cells recognize lipids presented by cluster ...
43
CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
... specific CD8 + T cells were primed in the draining lymph node and infiltrated the tumor but failed to control tumor growth ...T cells and tumor infiltration but had only a transient control in tumor ...
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HLA-E-Restricted Cross-Recognition of Allogeneic Endothelial Cells by CMV-Associated CD8 T Cells: A Potential Risk Factor following Transplantation
... HLA-E-restricted CD8 T cell population that was detected in the PBL of a kidney transplant patient after its CMV ...monoclonal CD8 T cell population represents a sizable fraction in the blood (3% of PBL) ...
15
Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells
... CSC-like cells to antigen-specific CD8 + T ...CSC-like cells and non-CSCs were mixed in equal numbers, and used as targets for killing by FluM1-speci fic CD8 + T cells at different ...
11
Transcriptional regulation of effector CD8+ T cell differentiation and molecular dysfunction during HIV-1 infection
... T cells (McMichael, Borrow et ...HIV-specific CD8+ T cell response which peaks just prior to the decline in viremia and is important in maintaining the viral load at stable levels (Koup, Safrit et ...of ...
192
Involvement of CD8+ T Cells in Multiple Sclerosis
... these cells are mucosal-associated invariant T (MAIT) cells. MAIT cells are a subset of innate effector memory T cells bearing a semi-invariant TCR ...MAIT cells are present in ...
10
Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand
... T cells in cancer ...memory-like CD8 + T cells are more potent and persist longer than effector memory-like T cells in the setting of ACT (44,45), their increased requirement for ...
17
Expansion of the CD8 memory T cells : implications for the self-renewal gene Hoxb4
... cellules CD8 T mémoire (Tm) offrent une protection tout au long de la vie contre les infections ...prolifération. CD8 Tm et CSH partagent partiellement un profil transcriptionnel, y compris certains gènes ...
113
Function of the immunoregulatory CD4-CD8- T cells in the context of autoimmune diabetes
... T cells migrated to the pancreas where they could eliminate autoreactive B ...B cells are defined by their ability to produce autoantibodies and present self-antigens to autoreactive T cells thereby ...
241
CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate
... T cells gradually lose contact with antigen-expressing tumor ...T cells were adoptively transferred into TRP-SIY mice followed by WSN-SIY ...T cells at indicated time point ...+ cells ...
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