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drug-induced liver injury

Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation

Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation

... the drug ( Larrey et ...paracetamol-induced liver injury has been demonstrated but this method of diagnosis but is not entered in the clinical practice and finally not necessary in most of ...

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Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

... of liver injury in COVID-19 patients, especially in those with obesity and related metabolic ...is induced by the virus or triggered by drugs and not related to any significant pre-existing ...

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Alteration of mitochondrial DNA homeostasis in drug-induced liver injury

Alteration of mitochondrial DNA homeostasis in drug-induced liver injury

... In liver, genetic or acquired impairment of mtDNA homeostasis can reduce ATP output but also decrease fatty acid oxidation, thus leading to different hepatic lesions including massive necrosis and microvesicular ...

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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

... of drug-induced liver injury, which involves the parent drug or a reactive metabolite gener- ated through cytochromes ...severe liver lesion usually associated with liver ...

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Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System

Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System

... identified 6515 patients hospitalized with drug-induced liver injury, or drug intoxications (using the ICD-10 codes K71 and T36-T65), among which 33.5% were acute hepatitis [17]. This ...

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Role of endoplasmic reticulum stress in drug-induced toxicity

Role of endoplasmic reticulum stress in drug-induced toxicity

... (e.g., liver, intestine) (Zhou et ...tipranavir induced only a weak or no ER stress in the different tested experi- mental models (Wu et ...significantly induced ER stress and cell death in mouse ...

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Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context

Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context

... fatty liver does not affect renal function and CKD development can be induced only by an alteration of intra-renal metabolism and without hepatic steatosis, whereas many recent studies suggested a causal ...

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EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.

EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.

... In accordance with previous results [31], anoxia/ reoxygenation of liver mitochondria induced a decrease in phosphorylating and uncoupled respiration rates and a decrease in the ADP/O ratio. The decrease in ...

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View of Drug-Induced Lung Toxicities: What the Intensivist Should Know?

View of Drug-Induced Lung Toxicities: What the Intensivist Should Know?

... 23. Shah RR, (2016) Tyrosine kinase inhibitor-induced interstitial lung disease: clinical features, diagnostic challenges, and thera- peutic dilemmas. Drug Saf 39: 1073 –1091 24. Naidoo J, Wang X, Woo KM, ...

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Cell-specific prediction and application of drug-induced gene expression profiles

Cell-specific prediction and application of drug-induced gene expression profiles

... measured drug profiles only, and results were excluded from the analysis when both AUCs were < ...either drug set (for the measured or predicted profile sets) had < 3 positive ...

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Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis

Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis

... and liver, thus re flecting an impairment of mtFAO in the remaining viable ...(a drug also leading to centrilobular necrosis but without primarily affecting mitochondrial function) did not cause any signi ...

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View of Drug-induced lung diseases in the intensive care unit

View of Drug-induced lung diseases in the intensive care unit

... Introduction En raison de la difficulté de leur diagnostic, la fréquence des pneumopathies médicamenteuses (PM) nécessitant une hos- pitalisation en réanimation est mal connue et peut être sous- estimée. Les quelques ...

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Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.

Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.

... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau ...

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Surgical factors and not donor type per se are risk factors for acute kidney injury after liver transplantation

Surgical factors and not donor type per se are risk factors for acute kidney injury after liver transplantation

... Results: Seven strongest predictors of DCD graft survival were identified: functional donor warm ischemia, cold ischemia, recipient MELD, recipient age, donor age, previous OLT, and donor body-mass-index (BMI). A ...

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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

... of liver biopsy biomarkers are widely used as a non-invasive alternative in patients with chronic liver disease to assess fibrosis stage and necroin- flammatory activity ...

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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.

... detect liver hypoxic areas, an intraperitoneal injection of 60mg/kg pimonidazole (Hypoxyprobe TM -1 kit, Chemicon International, Temecula, CA) was performed one hour before ...

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Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

... tissue injury and inflammation, extensive cell death may lead to tissue dysfunction or organ failure as demonstrated in this ...microbially induced chronic inflammation in the colon and acute sterile ...

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Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

... We have also identified a pathway that is a potentially novel regulator of NET formation — the antiin- flammatory, proresolving lipoxin pathway. Lipoxins are endogenous lipid mediators produced in response to ...

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Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.

Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.

... severe liver injury, hepatic cells release growth factors, cytokines and chemokines creating a specific microenvironment, which primes quiescent pool of hepatic stem cells ...

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Drug‐induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis

Drug‐induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis

... main drug classes reported in the literature —by decreasing frequency —are NSAIDs (ibuprofen, naproxen), antimicro- bials (mainly sulfamethoxazole/trimethoprim), monoclonal antibodies (adalimumab, cetuximab, ...

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