Double-Stranded DNA
Evolutionary history of bacteriophages with double-stranded DNA genomes
... with double-stranded DNA genomes attain the rank of the order Caudovirales and are divided into three main families according to their tail morphology: Siphoviridae (long noncontractile tail), Myo- ...
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Kinesin KIFC1 actively transports bare double-stranded DNA
... the DNA molecule from its vector occurs in the cytoplasm ...naked DNA is mostly degraded in the cyto- plasm by nuclease enzymes, some DNA molecules enter the nucleus and may be included in the ...the ...
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Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA
... are DNA repair enzymes; and the function of ABH6 remains to be ...of DNA adducts have been identified as substrates for AlkB and its mammalian homologs, ABH2 and ABH3, both in vitro and in ...other ...
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Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double-stranded DNA viruses
... non-AcMNPV DNA, which is somewhat surprising because our earlier works, based on twenty-one AcMNPV populations reanalyzed here, have shown that a large number of host TEs systematically inte- grate into AcMNPV ...
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Acheta domesticus Volvovirus, a Novel Single-Stranded Circular DNA Virus of the House Cricket
... single stranded. Native viral DNA was used for double-stranded DNA synthesis at 30°C by 29 DNA polymerase ( 3 ...Amplified DNA was digested with MboI, cloned into the ...
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Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
... gous double-stranded DNA (dsDNA), leading to strand ...of DNA strand exchange tolerates some differences between the molecules involved, thereby creating a hy- brid dsDNA molecule called a ...
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Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)
... of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation ...nuclear DNA has been explored in detail, much less is known about the repair of DNA alkylation damage in ...
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High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes
... single-stranded DNA (ssDNA), which is a transient state in many DNA metabolic processes such as replication, repair and recombination ...from DNA-damaging ...studying DNA–protein ...
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Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches
... Isothermal difference spectra (IDS) were calculated by subtraction of the UV‐spectra of a given sample acquired in absence or presence (100 or 0 mM for steady state measurements, and 5 mM added for time‐dependent ...
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Excited states and energy transfer among DNA bases in double helices
... the double helices than when they are dissolved in bulk aqueous ...of double helices are still restricted, can greatly contribute to elucidate many of the questions described ...a DNA double ...
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The Secret Life of Chromosome Loops upon DNA Double-Strand Break
... The DNA Double Strand Break response and repair DNA Double Strand Breaks (DSBs) represent challenging lesions for cells, as they can lead to major genome rearrangement such as translocations, ...
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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation
... 4 To further investigate if TADs dictate H2AX spreading, we used the CRISPR/Cas9 system to induce a single DSB at two designed positions within the same TAD, and investigated both chromosome conformation and H2AX ...
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ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
... to DNA-PK, further assembly of the whole NHEJ complex including proteins of the ligation complex (Figure 5 ...and DNA-PKcs, ATM prevents engagement of seDSBS re- pair into NHEJ through phosphorylation of ...
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High-Energy Long-Lived Excited States in DNA Double Strands
... by DNA induce photoreactions leading to carcinogenic mutations has triggered numerous ...some DNA helices presenting an emission band at longer wavelengths compared to those the monomeric chromophores [5, ...
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Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2
... the double mutant R361A-R362A exhibited a remarkable 6-fold lower binding capacity for tRNA (Fig- ure 3 ...this double mutant is a direct effect of the missing pos- itive charges and not a consequence of ...
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Ultrafast excited state deactivation and energy transfer in guanine-cytosine DNA double helices
... Ultrafast excited state deactivation and energy transfer in guanine-cytosine DNA double helices François-Alexandre Miannay, Ákos Bányász, Thomas Gustavsson and Dimitra Markovitsi*... ABS[r] ...
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Activation of mast cells by double-stranded RNA: evidence for activation through toll-like receptor 3 (TLR3)
... Results: Viruses and polyI:C induced IFN-a and IFN-b production. PolyI:C did not induce TNF, IL-1b, IL-5, or GM- CSF production, in contrast with other TLR ligands (LPS, peptidoglycan, CpG-A, or flagellin). IFN-a ...
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Determination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry
... + DNA) species for Hoechst 33258, Hoechst 33342, DAPI and berenil with duplex d(GGGG(A/T) 4 GGGG)´ d(CCCC(A/T) 4 CCCC), which were undetectable with the other ...
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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
... single-stranded DNA to damaging agents as well as their potential to impede replication fork progression (reviewed in ...some DNA damaging agents such as H 2 O 2 and UV 21 – 23 , a feature also ...
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Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.
... of DNA involves loss of information on the two strands of the DNA fibre and thus cannot be repaired by simple copying of the complementary strand which is possible with single-strand DNA ...on ...
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