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double-strand break repair

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining

... and repair; signaling and resection DSB signaling At an early step, double-strand break recogni- tion is accomplished by the MRN complex (MRE11, RAD50 and NBS1), which acts in an activation ...

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The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication

The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication

... initial break of the replica- tion fork is randomly located on the chromosome and so cannot be detected in a population of cells ...subsequent break occurs in the dif/terC region but only if the cell is a ...

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Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

... to repair DNA DSBs is observed during adipocyte differentiation To investigate the DNA DSB repair activity of post-mitotic adipocytes, the murine pre-adipocyte 3T3F442A cell line was ...the break ...

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Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair

Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair

... and repair of both unscheduled and programmed DSBs by homologous recombination ...to double-stranded DNA substrates but does not contain intrinsic nuclease ...

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Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

... mutants. Double mutant ku80 xrcc1 plants are at least as c-hypersensitive as the xrcc1 mutants; however, as discussed below, the complexity and relative imprecision of survival measurements in plant radiobiology ...

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The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.

The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.

... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...

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Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis

Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis

... The double-strand-break repair model for ...DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein ...

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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

... DNA strand within the R-loop and the DSB is created by a sec- ond SSB next to the R-loop on the opposing DNA ...DSB repair by homologous recombination ( Cec- caldi et ...the repair of transcriptional ...

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MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

... Hormad1 is required for the stabilization of MEI4 foci We then tested the role of SYCP3 and HORMAD1, two meiotic chromosome structural proteins, in MEI4 foci formation. SYCP3 assembles on meiotic chromosome axes at the ...

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Signaling of double strand breaks and deprotected telomeres in Arabidopsis

Signaling of double strand breaks and deprotected telomeres in Arabidopsis

... the break by PIKK is an early cellular response to the induc- tion of DSBs and occurs over 50 kb in yeast to 2 Mb for H2AX in ...its repair ( Kinner et ...and repair factors, H2AX phosphoryla- tion ...

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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

... DNA break capture 14 , high-throughput, genome-wide, translocation sequencing 15 and more recently End-Seq 16 and DSBCapture 17 ...or repair proteins such as p53- binding protein 1 or the phosphorylated ...

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Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

... Stamper et al, 2013 ). They appear before or at the beginning of meiotic prophase and the number of foci decreases as chromosomes synapse in S. cerevisiae ( Li et al, 2006 ; Maleki et al, 2007 ) and in M. musculus ( ...

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Ku counteracts mobilization of PARP1 and MRN inchromatin damaged with DNA double-strand breaks

Ku counteracts mobilization of PARP1 and MRN inchromatin damaged with DNA double-strand breaks

... the repair of DNA DSBs. INTRODUCTION Double-strand break (DSB) is toxic DNA damage that, if improperly repaired, can lead to cell death or cancer fol- lowing genomic rearrangement ...DSB ...

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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.

C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.

... Received July 19, 2015; Revised February 26, 2016; Accepted February 29, 2016 ABSTRACT Non-homologous end joining is a ligation process re- pairing DNA double strand breaks in eukaryotes and many ...

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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

... with repair proteins in yeast and mammals and localizes to the site of damage during replication 18 , 19 ...DNA double-strand break (DSB), a form of DNA damage largely induced upon ...

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SIRT6 is a DNA double-strand break sensor

SIRT6 is a DNA double-strand break sensor

... These results indicate that SIRT6 recruitment is independent of known DSB sensors and is upstream of ATM and H2AX phosphorylation. To understand whether SIRT6 is recruited through by signaling initiated at the sites of ...

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The Secret Life of Chromosome Loops upon DNA Double-Strand Break

The Secret Life of Chromosome Loops upon DNA Double-Strand Break

... DNA Double Strand Break response and repair DNA Double Strand Breaks (DSBs) represent challenging lesions for cells, as they can lead to major genome rearrangement such as ...

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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

... DSB repair signaling events such as the phosphorylation of H2AX, the eviction of histone H1 and the accrual of 53BP1, MDC1 and ubiquitin, allowing a DSB signaling at the megabase ...the break itself that ...

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Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

... DNA double-strand break determination The determination of DSB formation and repair was car- ried out by pulsed field agarose gel electrophoresis (PFGE) through the clamped homogeneous ...

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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

... and Repair during Programmed Genome Rearrangements in ...DSB, double- strand break; IES, internal eliminated sequence; MAC, macronucleus; MIC, micronucleus; Pgm, PiggyMac; Tpb, Pgm ...

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