double-strand break formation
Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
... Stamper et al, 2013 ). They appear before or at the beginning of meiotic prophase and the number of foci decreases as chromosomes synapse in S. cerevisiae ( Li et al, 2006 ; Maleki et al, 2007 ) and in M. musculus ( ...
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MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse
... DSB formation, but is required for SYCP2 recruitment on axial elements and for full homologous synapsis (Kouznetsova et ...DSB formation, as in Hormad1 2/2 mice, the DSB level shows a 2- to ...the ...
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en fr DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes Formation et signalisation des cassures double-brin de l'ADN lors d'un blocage de la transcription
... To assess the potential role of RhoB in the cellular response to CPT, we compared survival of WT and RhoB-deficient RhoB⫺/⫺ E6-immortalized MEF cells after CPT treatment.. Cells were tre[r] ...
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DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes
... To assess the potential role of RhoB in the cellular response to CPT, we compared survival of WT and RhoB-deficient RhoB⫺/⫺ E6-immortalized MEF cells after CPT treatment.. Cells were tre[r] ...
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SPO11.2 is essential for programmed double strand break formation during meiosis in bread wheat (Triticum aestivum L.)
... Analysis of the three homoeologous copies of TaSPO11-2 of bread wheat and of meiosis in the.. 42.[r] ...
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Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.
... DNA double-strand break determination The determination of DSB formation and repair was car- ried out by pulsed field agarose gel electrophoresis (PFGE) through the clamped homogeneous ...
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Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair
... with double-stranded, but not single-stranded nucleic acids ...the formation of rather large multimeric assemblies, in particular when considering the low molecular weight of Paramecium CtIP ...the ...
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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
... DNA strand within the R-loop and the DSB is created by a sec- ond SSB next to the R-loop on the opposing DNA ...DSB formation by cleaving R-loops and/or by resecting DNA after a break is ...
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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?
... DSB Formation and Repair during Programmed Genome Rearrangements in ...DSB formation and ...DSB, double- strand break; IES, internal eliminated sequence; MAC, macronucleus; MIC, ...
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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
... Senataxin removes DSB-induced RNA:DNA hybrids in active loci. A well described function of senataxin is its ability to unwind RNA:DNA hybrids, hence regulating R-loops stability on the genome. Given senataxin recruitment ...
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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation
... In summary, our work unambiguously shows that TADs are the template for the spreading of many DSB repair signaling events such as the phosphorylation of H2AX, the eviction of histone H1 and the accrual of 53BP1, MDC1 and ...
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The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication
... the formation of a sigma-replicating ...initial break of the replica- tion fork is randomly located on the chromosome and so cannot be detected in a population of cells ...subsequent break occurs in ...
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Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
... Results Enhanced capacity to repair DNA DSBs is observed during adipocyte differentiation To investigate the DNA DSB repair activity of post-mitotic adipocytes, the murine pre-adipocyte 3T3F442A cell line was used. When ...
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The Secret Life of Chromosome Loops upon DNA Double-Strand Break
... the formation of arrays of chromatin loops anchored to a chromosomal axis ...crossover formation depends on the “homologous bias” that consists in choosing the homologous chromosome as a template over the ...
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en fr Role of chromatin remodeling enzymes in the repair of DNA double strand breaks and genetic instability Rôle des modifications de la chromatine dans la réparation des cassures double-brin de l'ADN et la stabilité génétique
... RESUME Le génome humain est constamment la cible d'agents qui endommagent l’ADN. Ces dommages sont multiples et variés tels que les cassures simple et double brin (DSB). Les DSBs sont des lésions très toxiques ...
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La formation des labiales-vélaires à double occlusion en Niger-Congo
... à double fermeture, bilabiale et vélaire, très rares dans le monde et, au contraire, fréquentes en Afrique de l’Ouest, se seraient conservées telles quelles depuis l’époque du ...
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... Received July 19, 2015; Revised February 26, 2016; Accepted February 29, 2016 ABSTRACT Non-homologous end joining is a ligation process re- pairing DNA double strand breaks in eukaryotes and many ...
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Fractal Kelvin-Helmholtz break-ups
... Secondary Break-ups A secondary KH instability develops on the baroclinically-enhanced vorticity ridge We carry out numerical simulations of the temporally-evolving infinite-Schmidt number mixing-layer between ...
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ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
... Figure 5. Proposed model for Ku and DNA-PKcs eviction from a single-ended DSB. At a seDSB, Ku loads at the DNA end and MRN associates concomi- tantly on the break side (i). When efficient, ATM is activated upon ...
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Physical interaction between the histone acetyl transferase Tip60 and the DNA double strand breaks sensor MRN complex
... Figure 3: Tip60 is involved in MRN foci formation Cells were electroporated with the indicated siRNA and 48h later exposed to IR (8 Gy) and fixed 1h or 6h post irradiation. Cells were then subjected to an ...
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