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double-strand break DNA repair

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining

... A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic instability and pro- found genome ...DSB repair: homolo- gous recombination (HR) and non-homologous ...

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The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication

The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication

... terminus DNA loss was observed in the recBC ...terminus-localized DNA breaks are only generated in the recBC mutants (Sinha et ...of DNA loss observed in a recBC mutant did not correspond to the ...

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Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair

Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair

... 4.5. Cloning, expression and purification of recombinant PtCtIPa The PtCtIPa open reading frame (NCBI database GI accession number 145537105) was synthesized, cloned into pUC57 and verified by sequencing (GeneScript, ...

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Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

... efficiently repair DNA double strand breaks (DSBs), and one might reasonably speculate that efficient DNA repair of these threatening DNA lesions, is needed in cells of ...

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The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.

The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.

... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...

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Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

... on DNA sequence homology an orthologue of the XRCC1 gene is clearly identifiable in the Arabidopsis genome (Uchiyama et ...mutants. Double mutant ku80 xrcc1 plants are at least as c-hypersensitive as the ...

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Signaling of double strand breaks and deprotected telomeres in Arabidopsis

Signaling of double strand breaks and deprotected telomeres in Arabidopsis

... the break by PIKK is an early cellular response to the induc- tion of DSBs and occurs over 50 kb in yeast to 2 Mb for H2AX in ...monitoring DNA damage and its repair ( Kinner et ...and repair ...

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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

... displaced DNA strand within the R-loop and the DSB is created by a sec- ond SSB next to the R-loop on the opposing DNA ...DSB repair by homologous recombination ( Cec- caldi et ...the ...

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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

... from DNA-ends, DSB-induced RNA:DNA hybrids may exert some important function in the ...RNA: DNA hybrids could contribute to setup an adequate chromatin ...at break site, where it mediates H4 and H2A ...

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Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

... of DNA strand inter- ruptions. It is involved in early DNA damage recognition [6], base excision repair [7,8] and genome surveillance in a variety of situations (for a review see ...several ...

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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.

C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.

... pairing DNA double strand breaks in eukaryotes and many ...binds DNA ends and recruits other factors which can access DNA ends through the threading of Ku inward the DNA, making ...

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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

... (IDLV)-mediated DNA break capture 14 , high-throughput, genome-wide, translocation sequencing 15 and more recently End-Seq 16 and DSBCapture 17 ...or repair proteins such as p53- binding protein 1 or ...

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Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

... A previous study showed that IHO1 is required for MEI4 and REC114 focus formation on axis and that it directly interacts with REC114 by two-hybrid assay ( Stanzione et al, 2016 ). As IHO1 interacts with HORMAD1, IHO1 ...

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Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis

Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis

... of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces ...5’ strand termini of meiosis- specific double-strand breaks in ...

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MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

... DSB repair foci (RAD51 and/or ...DSB repair and homologous synapsis are partially deficient (Bannister et ...the double Rad21L 2/2 Rec8 2/2 mutant, which has a greater reduction of the number of DSB ...

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SIRT6 is a DNA double-strand break sensor

SIRT6 is a DNA double-strand break sensor

... flag-tagged repair proteins were purified and incubated with DNA, then immunoprecipi- tated along with the DNA that they ...The DNA was later purified and its enrichment was mea- sured by ...

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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

... DSB repair signaling events such as the phosphorylation of H2AX, the eviction of histone H1 and the accrual of 53BP1, MDC1 and ubiquitin, allowing a DSB signaling at the megabase ...the break itself that ...

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The Secret Life of Chromosome Loops upon DNA Double-Strand Break

The Secret Life of Chromosome Loops upon DNA Double-Strand Break

... and repair? The genomic localization of DSBs strongly impacts their signalization and ...DSB repair [21–23]; or bona fide chromatin constituents such as KAP1 for heterochromatic repair [24,25]) as ...

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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

... and Repair during Programmed Genome Rearrangements in ...Programmed DNA elimination takes place during MAC ...cleave DNA at IES ends, indicative of tight coupling between DSB formation and ...DSB, ...

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Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

... Introduction DNA damage can be caused by radiation, by organic and inorganic chemical agents and by enzymes that have the roles of promoting natural methylation and deamination, such as members of the ...

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