DNA Double-stranded Breaks
Ku counteracts mobilization of PARP1 and MRN inchromatin damaged with DNA double-strand breaks
... emerged which operates preferentially under C-NHEJ defective conditions. Although B-NHEJ appears particularly relevant to genomic instability associated with cancer, its components and regula- tion are still largely ...
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XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition
... single-ended DNA double-strand breaks (seDSBs) that are repaired predominantly through RAD51-mediated homologous recombination ...and DNA repair protein XAB2 leads to increased temozolomide ...
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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
... single-stranded DNA to damaging agents as well as their potential to impede replication fork progression (reviewed in ...some DNA damaging agents such as H 2 O 2 and UV 21 – 23 , a feature also ...
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Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)
... of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation ...nuclear DNA has been explored in detail, much less is known about the repair of DNA alkylation damage in ...
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Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA
... of DNA damage is crucial for chromosome integ- rity, since it prevents mutations, chromosomal aberrations and errors in essential processes such as transcription, replication and chromosome segregation ...
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... the DNA ligase components as well as other accessory NHEJ ...ble stranded (ds) DNA molecule ( 21 ...the DNA molecule when additional Ku proteins enter by the ends ( 22 , 23 , 24 ...the ...
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Signaling of double strand breaks and deprotected telomeres in Arabidopsis
... sensing, double strand breaks, telomere, DNA repair DSBs REPAIR PATHWAYS IN ARABIDOPSIS THALIANA Double strand breaks (DSB) repair pathways are classed as either homologous ...
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Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
... A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic instability and pro- found genome ...single-stranded DNA (ssDNA) resection and requires sequence homology ...
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A conserved MCM single-stranded DNA binding element is essential for replication initiation
... Single-Stranded DNA Binding motif ...The DNA-binding consists predom- inantly of interactions with the sugars and bases rather than the backbone ...
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Cis, Isotactic Selective ROMP of Norbornenes Fused with N-Arylpyrrolidines. Double Stranded Polynorbornene-Based Ladderphanes with Z-Double Bonds
... polynorbornene-based double stranded ladderphanes 11 with trans double bonds can form a two-dimensional well-oriented array on highly ordered pyrolytic graphite surface (HOPG) as revealed by scanning ...
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Acheta domesticus Volvovirus, a Novel Single-Stranded Circular DNA Virus of the House Cricket
... single stranded. Native viral DNA was used for double-stranded DNA synthesis at 30°C by 29 DNA polymerase ( 3 ...Amplified DNA was digested with MboI, cloned into the ...
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Condensation performance of metal-framed double windows with and without thermal breaks
... The criterion for satisfactory thermal performance is that the difference between the inside glass-centre index and the minimum temperature index of the inside surface [r] ...
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en fr Role of chromatin remodeling enzymes in the repair of DNA double strand breaks and genetic instability Rôle des modifications de la chromatine dans la réparation des cassures double-brin de l'ADN et la stabilité génétique
... RESUME Le génome humain est constamment la cible d'agents qui endommagent l’ADN. Ces dommages sont multiples et variés tels que les cassures simple et double brin (DSB). Les DSBs sont des lésions très toxiques ...
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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
... IIβ-mediated DNA cleavage could underlie activity-induced DSB formation in ...Activity-Induced DNA DSBs Occur within CTCF-Generated Topological Domains We sought to understand the properties that could ...
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SIRT6 is a DNA double-strand break sensor
... undamaged DNA could not enter this tunnel, but broken DNA ends ...SIRT6 DNA-binding ...their DNA-binding ...the DNA- binding capacity ( Figure 4F–G ...
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Kinesin KIFC1 actively transports bare double-stranded DNA
... nucleoporins NUP50 and NUP153 (54). This suggests that KIFC1 may have a post-mitotic role because of this double affinity for nuclear pores and DNA molecules, either directly or mediated by DNA- ...
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Bub3–BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes
... of the downstream pathways that repair the damage, either by nonhomologous end joining (NHEJ) or homology-targeted re- pair (Mari et al., 2006; Giunta et al., 2010; Gomez-Godinez et al., 2010; Peterson et al., 2011; ...
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Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing
... enous DNA, which might affect the results of bioinformatic analyses, as reported in previous ...λ DNA along with the experi- mental samples. Finally, DNA sequences can be unevenly amplified during ...
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en fr Signalization and repair of the DNA double-strand breaks of in the cerebral tumors: Modulation of the radiation response with the chemotherapy treatments. Signalisation et réparation des cassures double-brin de l'ADN dans les gliomes : Modulation de la réponse aux traitements chimio-radiothérapeutiques.
... cassures double-brin de l'ADN dépendant de la protéine MRE11 mais indépendante de la phosphorylation de H2AX a été mise en évidence suite à une étude des artéfacts de la technique d’immunofluorescence et à une ...
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Exciton States of Dynamic DNA Double Helices: Alternating dCdG Sequences
... composed of only adenine-thymine base pairs. 21 The dominant role of homogenous broadening in the spatial extent of excited states within the double helix found here confirms our findings on (dA) 10 .(dT) 10 . 27 ...
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