... .. DiffuselargeB-celllymphomas (DLBCLs) are markedly heterogeneous, and there is increasing evidence that the biological features of these tumors vary according to the primary site ...
... Among large biopsy specimens (n=79), 18% had a prominent nodular pattern consistent with transformed follicular lymphomas, 35% had a minor nodular component (<50%) interpre[r] ...
... biopsy, cell-free DNA (cfDNA) can provide information regarding basal tumoral genetic patterns and changes upon ...30 diffuselargeB-celllymphomas (DLBCL), we determined the ...
... in diffuselargeB-celllymphomas involves expansion of myeloid-derived suppressor ...programmed cell death 1 and programmed cell death ligand 1 expression in the tumour ...
... with diffuselargeB-cell lymphoma treated with R-CHOP: a GELA study ...in diffuselargeB-celllymphomas treated within randomized trials of the German ...
... Our analysis has shed light on peculiar pathologic features of WR DLBCLs, somewhat different from those usually reported for DLBCLs, NOS. First, we show that WR DLBCLs comprise a majority of tumors (60%) with a GCB-like ...
... DISCUSSION In previous studies, we had shown that EBI3 is expressed by tumor cells in various types of B- or T-celllymphomas, especially in DLBCL, in most cases in the absence of p28, its binding ...
... Several retrospective studies reported PB lympho- mas separately and suggested that these topographic variants may have a seemingly favorable prognostic particularly when combining chemotherapy and radi- ation therapy ( ...
... Our analysis has shed light on peculiar pathologic features of WR DLBCLs, somewhat different from those usually reported for DLBCLs, NOS. First, we show that WR DLBCLs comprise a majority of tumors (60%) with a GCB-like ...
... In B-celllymphomas, the myeloid compartment contributes to prognosis Lymphomas constitute a large group of cancer arising from lymphoid or extra- nodal tissues ...are ...
... Discussion We previously identified PASD1 as a novel DLBCL-associated CTA using the SEREX technique (Liggins et al, 2004a,b). This approach, which relies upon the presence of a co-ordinated cellular and humoral ...
... of cell of origin signature in R-CHOP patients Wright et al established a predictor for Germinal Center (GC) and Activated B-Cell (ABC) classification of DLBCL lymphomas, based on the ...
... GC B cells and lymphoma cell lines in which it desensitizes cells to chemoattractant, localizing cells to the lymph node [ 29 ...and B cells, with a still-unclear ...in lymphomas [ 49 ...and ...
... The impact of RDI on outcome in lymphomas treated with CHOP and related regimens, has been investigated before the introduction of rituximab [9-11,15,16]. Since the introduction of rituximab at the end of the 90s, ...
... frequency of the two main molecular –defined subtypes, namely, germinal center B-cell –like (GCB) and activated B-cell –like (ABC) subtypes, differs according to patient age. Additionally, an ...
... Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are B-cell malignancies that are primarily located in lymph ...from B-cell precursors ( 69 ...Aggressive lymphomas are rapidly ...
... Méthodes de biologie cellulaire B. Protocole Les tests de migration en chambre de Boyden sont effectués en plaques 96 puits HTS transwell (Corning LifeScience). L’insert est constitué d’une membrane en ...
... non-Hodgkin's lymphomas. Mantle cell lymphoma generally affects patients over 60 ...mantle cell lymphoma. The cell-proliferation marker Ki-67, the Mantle Cell Lymphoma International ...
... nuclear translocation, MAP kinase activation (ERK, JNK and p38), tran- scription and cytokine release. CD69 and ICOS, upregulated follow- ing TCR engagement, act as co- stimulatory molecules. Syk is a ZAP-70 homolog ...