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Development of drug resistance limites the effectiveness of chemotherapy treatments

The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project Rationale and design of the database and the collection of evidence available at approval of novel drugs

The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project Rationale and design of the database and the collection of evidence available at approval of novel drugs

... up the database and realized the project in a multidisciplinary team including experts in clinical trial methodology and conduct, clinical epidemiology, health technology assessment, biostatistics, clinical ...

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Inhibition of patched drug efflux increases vemurafenib effectiveness against resistant braf(V600E) melanoma

Inhibition of patched drug efflux increases vemurafenib effectiveness against resistant braf(V600E) melanoma

... marker of gastric and thyroid cancers [ 9 , 10 ]. We previously showed, for the first time, that Ptch1 has a drug efflux activity and contributes to the resistance of cancer ...

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Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

... models of solid and haematological ...inhibition of the PI3K pathway increases androgen receptor signal- ling, while androgen receptor inhibition activates AKT signalling [ 29 ...(inhibitor of ...

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Experimental models for the development of new medical treatments in prostate cancer

Experimental models for the development of new medical treatments in prostate cancer

... cause of death and morbidity in western countries, one major obstacle in the progress of prostate cancer studies has been the limited number of relevant preclinical ...constitute ...

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DECIPHERING THE MECHANISMS OF MEDULLOBLASTOMA RESISTANCE TO RADIO/CHEMOTHERAPY: TOWARD PERSONALIZED TREATMENTS?

DECIPHERING THE MECHANISMS OF MEDULLOBLASTOMA RESISTANCE TO RADIO/CHEMOTHERAPY: TOWARD PERSONALIZED TREATMENTS?

... Sonia Martial, Álvaro Javier, Feliz Morel, Yannick Comoglio, Magalie Leloire, Audrey Claren, Jérôme Doyen, Matthew Selby, Steven Clifford, Gilles Pages. To cite this version:[r] ...

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Mathematical study and asymptotic analysis of a model for tumor drug resistance

Mathematical study and asymptotic analysis of a model for tumor drug resistance

... proof of the solution to our model has been derived. The main idea of the proof was that the tumor remains compactly supported in the domain of interest up to a ...

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Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.: Mechanism of entecavir resistance

Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.: Mechanism of entecavir resistance

... year of entecavir therapy, HBV- DNA had decreased by three logs but viral breakthrough (more than 1-log increase) was observed two years ...later. The patient is currently being treated with lamivudine and ...

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Design, Development and Optimization of Topotecan Hydrochloride Solid Lipid Nanoparticles for Oral Chemotherapy

Design, Development and Optimization of Topotecan Hydrochloride Solid Lipid Nanoparticles for Oral Chemotherapy

... Abstract The objective of this research work was to formulate and evaluate solid lipid nanoparticles of anticancer drug topotecan hydrochloride in order to sustain its release and therefore ...

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Analytics for financing drug development

Analytics for financing drug development

... show the results of applying the framework Spearmint based on the paper of Gelbart et ...use the same setup described for Figure 2-6, using a capital amount of $2650 ...

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Spatial modelling of tumour drug resistance: the case of GIST liver metastases Mathematical Medicine and Biology Advance

Spatial modelling of tumour drug resistance: the case of GIST liver metastases Mathematical Medicine and Biology Advance

... towards the tumour, we introduce a variable M that describes both vascularization, neovascularization and nutrients brought to the tumour thanks to an advection-diffusion ...M. The set of ...

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Cost-Effectiveness Indicator for Software Development

Cost-Effectiveness Indicator for Software Development

... choosing the underlying base measures. A serious limitation of BM is its dependence on the unit of the particular output measure ...indicator. The base measures of output ...

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City effectiveness in initiating and planning urgan [sic] development: the Welfare Island development.

City effectiveness in initiating and planning urgan [sic] development: the Welfare Island development.

... No longer able to rely on federal and state financial enticements, cities will not only have to deploy already scarce resources into the area of housing and related servi[r] ...

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Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database.

Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database.

... 50% of the therapies after six months of ...within the same period. This study faced three main drawbacks. Firstly, the number of patients recorded was limited and many differ- ...

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CCMC evaluation of the effectiveness of ridge vents

CCMC evaluation of the effectiveness of ridge vents

... Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous ...

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Use of infertility treatments in the French population

Use of infertility treatments in the French population

... advantage of data from the French national health insurance system, our work explores for the first time use of infertility treatment in a large representative ...4% of women aged 20-49 ...

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Risk of Drug-Drug Interactions in Out-Hospital Drug Dispensings in France: Results From the DRUG-Drug Interaction Prevalence Study

Risk of Drug-Drug Interactions in Out-Hospital Drug Dispensings in France: Results From the DRUG-Drug Interaction Prevalence Study

... by the World Health Organization as “the administration of many drugs at the same time or the administration of an excessive number of drugs” and continuous polypharmacy ...

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Assessing the cost‐effectiveness of integrated passives

Assessing the cost‐effectiveness of integrated passives

... to the direct material cost, yield aspects are also very important, since these values are very different for the various build-ups, as can be seen from ...2. The respec- tive substrate/board area ...

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The effectiveness of IFRS 8: Operating Segments

The effectiveness of IFRS 8: Operating Segments

... understand the entity’s past performance, to access more easily the entity’s risks and returns and to make more informed judgments about the entity as a ...users of financial statements ...

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Are Cryptomarkets the Future of Drug Dealing? Assessing the Structure of the Drug Market Hosted on Cryptomarkets

Are Cryptomarkets the Future of Drug Dealing? Assessing the Structure of the Drug Market Hosted on Cryptomarkets

... of the same type of drugs. Doing so may be indicative of aggressive advertising ...with the fact that the online market is one large virtual place, influences large firms to act ...

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Machine learning applications in drug development

Machine learning applications in drug development

... accurately drug effects is signature reversion, also called connectivity mapping, which focuses on expression measurements: given a pathological phenotype (‘‘query signature”) associated with the disease at ...

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