DEPENDENT MANNER
Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner
... in vivo under normal blood flow conditions, increased attention has been paid to the impact of complex hemodynamics such as flow acceleration found in stenosed arteries. We investigated the effect of flow acceleration, ...
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Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner
... SIM-dependent manner, and could also interact with TRIM5α, RanBP2, TNPO3, and TRIM34, next, we sought to investigate whether a multiprotein complex containing Daxx formed on incoming HIV-1 ...
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Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner
... Synaptic transmission usually depends on action potentials (APs) in an all-or-none (digital) fashion. Recent studies indicate, how- ever, that subthreshold presynaptic depolarization may facilitate spike-evoked ...
13
Macrophage bactericidal activities against [i]Staphylococcus aureus[/i] are enhanced [i]in vivo[/i] by selenium supplementation in a dose-dependent manner
... dose-dependent manner on macrophage activation, phagocytosis and bacterial killing, suggesting that inade- quate doses may cause a loss of macrophage bactericidal ...
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The varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a cell-type dependent manner.
... promoter-dependent manner, (ii) the phospho- rylation status of the protein influenced these regulatory properties, (iii) the effects of IE63 were correlated with a modification of chromatin structure, and ...
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Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner
... (Submitted 22 March 2011 – Final revision received 29 June 2011 – Accepted 30 June 2011 – First published online 14 September 2011) Abstract Long-chain (LC) n-3 PUFA have a broad range of biological properties that can ...
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Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem-Like Cells Fate in an Oxygen-Dependent Manner
... ATR-dependent manner, we used a specific inhibitor of ATR activity (ATRI) in co-treatment with GDC- ...was dependent of DNA damage, we analyzed γH2AX-expression and ...
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Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner
... (Submitted 22 March 2011 – Final revision received 29 June 2011 – Accepted 30 June 2011 – First published online 14 September 2011) Abstract Long-chain (LC) n-3 PUFA have a broad range of biological properties that can ...
21
A Virus Hosted in Malaria-Infected Blood Protects against T Cell-Mediated Inflammatory Diseases by Impairing DC Function in a Type I IFN-Dependent Manner
... Beyond the importance of our findings for the community working on malaria models, our work has fundamental relevance to understand how viruses shape inflam- matory diseases. We indeed reveal some of the molecular bases ...
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Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner
... We recently reported that DUSP3 plays an important role in innate immunity and most precisely in macrophages. Tumour-associated macrophages (TAM) display in general M2-like properties, although a high diversity exists [ ...
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Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes
... microtubule fibers that they could not be destabilized by Aurora B/C anymore, similar to what has been suggested in mitosis[33] (Figure S4A). If ongoing error correction was creating unattached kinetochores that ...
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A Unique cis-Encoded Small Noncoding RNA Is Regulating Legionella pneumophila Hfq Expression in a Life Cycle-Dependent Manner
... A. castellanii. An antisense RNA is present in the 5= untranslated region of hfq. We had previously established a complete transcriptional map of the L. pneumophila genome that revealed the presence of a dynamic pool of ...
19
Dual-specificity phosphatase 3 knockout female mice are resistant to LPS and to polymicrobial induced septic shock in TNF dependent manner.
... The Journal of Immunology, 2013, 190, 138.9 Copyright © 2013 by The American Association of Immunologists, Inc. 138.9 Dual-specificity phosphatase 3 knockout female mice are resistant to LPS and to polymicrobial induced ...
1
Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner
... Cells deficient for the CST and EJ proteins present long telomeric repeats Plants mutated for the CST complex and lacking KU80, XRCC1 and XPF are thus viable and do not present vis- ible genomic instability. ...
14
The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner
... To confirm that delta133p53 is involved in reducing the apo- ptotic effect of RhoB, we tested the sensitivity to camptothecin-induced apoptosis of SW480 cell lines that stably overexpres[r] ...
16
Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner
... Cancers 2020, 12, 1297 8 of 19 Cancers 2020, 12, x 9 of 22 Figure 4. Tspan8-dependent dermal invasion coincides with MMP-9 activity and local dissolution of collagen IV and requires surrounding keratinocytes. (a) ...
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Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner
... Strikingly, melanoma cells were unable to cross the DEJ when keratinocytes were not incorporated, regardless of their Tspan8 expression levels (Figure 2 a), even after 5 weeks of culture (not shown). This was consistent ...
19
The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner
... differentiation process in a robust manner. As the time-point of analysis, we chose four days after induction of differentiation, when both isoforms reached a comparable level of protein expression in our hands [ ...
18
Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.
... Given the critical role of macrophages in iron turnover in vivo, we next examined the effects of Nef in THP-1 cells and MDMs. We found that all nef alleles that modulated TfR surface levels in PBMCs were also ac- tive in ...
13
Dependent Random Choice
... of dependent random ...of dependent random choice which were needed to study embeddings of subdivisions of various graphs into dense ...of dependent random choice and concluding ...
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