Cytokine-induced killer cells
Regulatory role of natural killer T cells in diabetes
... diabetes induced by the lymphocyte choriomeningitis virus ...iNKT cells not only play an active role in the antiviral response, but also play a major role in the protection against diabetes [46] ...iNKT ...
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The role of natural killer cells in sepsis
... NK cells in different models of bacterial infections. Depletion of NK cells in SCID mice infected intranasally with Streptococcus pneumoniae resulted in signif- icantly lower bacteremia and inflammatory ...
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus
... the cytokine titers measured by ELISA in the serum of BALB/c mice at 36 h post-infection range between 5 and 10 ng/ml, and the volume of the lymph and blood of an adult mouse can roughly be estimated around 5 ml, ...
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Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective.: DNA integrity of iPS cells
... Page / 3 7 Overall, the studies suggesting that cell reprogramming may be inherently linked to DNA damage are counterbalanced by other works showing that the mutation status of iPSC lines is similar to that of their ...
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Blockade of store-operated calcium entry reduces IL-17/TNF cytokine-induced Inflammatory response in human myoblasts
... mononuclear cells (PBMC) from healthy donors activated or not with phytohemagglutinin (PHA) were added to myoblasts at a 5:1 ...TNFα induced in synergy CCL20 and IL- 6 production by myoblasts ...production ...
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Manufacturing Natural Killer Cells as Medicinal Products
... NK cells persist in vivo for short periods of time after adoptive ...YTS cells, HANK-1, and NKL cells), the NK-92 cell line (NantKWest ...NK cells has opened a new avenue to explore ( 68 , 69 ...
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Transgene-free hematopoietic stem and progenitor cells from human induced pluripotent stem cells
... (d) Flow cytometry analysis of human CD309, ITGA2, MPL and CKIT expression at D13 and D17 of EB culture. Fig. 2: Functional endothelio-hematopoietic profiling between D15 and D17. (a) Ex vivo tests probing the presence ...
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Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.: NK cells in chronic hepatitis C and hepatitis B
... NK cells expressing either NKG2A, and/or CD158a,h, CD158b,j differed significantly between HCV and HBV ...- cells was observed in HCV compared to HBV ...- cells were localized within necrotic ...+ ...
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Natural killer cell-based therapies
... NK cells free from inhibition, referred to as “alloreactive” NK ...NK cells transplanted in C2/C2 individuals do not find their cognate inhibitory ligands and become ...NK cells from the donor, which ...
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Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity
... NK cells that coexpress CD94/NKG2C and inhibitory receptors for HLA-C1 alleles and are correlated with the viral ...NK cells in the absence of exogenous signals and severely impaired IFN-c ...NK ...
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Deoxynivalenol Has the Capacity to Increase Transcription Factor Expression and Cytokine Production in Porcine T Cells
... Deoxynivalenol (DON) is a Fusarium mycotoxin that frequently contaminates the feed of farm animals. Pigs with their monogastric digestive system are in particular sensitive to DON-contaminated feed. At high ...
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Transient Complement Inhibition Promotes a Tumor-Specific Immune Response through the Implication of Natural Killer Cells
... inhibition of complement increased NK cell numbers in spleen and tumor leading to the.. 68.[r] ...
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OA031-05. HIV escape from natural killer cytotoxicity: Nef inhibits NKp44L expression on HIV-infected CD4+ T cells
... NKp44L+CD4+ cells are highly sensitive to the NK lysis ...HIV-infected cells are resistant to NK killing, suggesting that HIV-1 develop escape mechanisms to counteract NK cytotoxic- ...
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Functional Assessment of the Induced Pluripotent Stem Cells (iPSC)-derived β-like Cells
... the Induced Pluripotent Stem Cells (iPSC)-derived -like Cells Manon Jaffredo 1 , Nicole Krentz 2 , Benoite Champon 2,3 , Fernando Abaitua 2 , Antoine Pirog 4 , Nicola Beer 2 , Anne Clark 3 , ...
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Killer ILCs in the Fat
... The viral attachment protein of RSV has many surprising features, especially its mimicry of fractalkine (CX3CL1). Zhivaki et al. (2017) now show that, in addition to using this homology to attach to ciliated ...
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Ferrocenyl flavonoid-induced morphological modifications of endothelial cells and cytotoxicity against B16 murine melanoma cells
... 1 These authors contributed equally to the work. Abstract With the aim of improving the cytotoxic and vascular disrupting activities of flavonoids, several classes of ferrocenyl-modified flavonoids were prepared and ...
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Increased Degranulation of Natural Killer Cells during Acute HCV Correlates with the Magnitude of Virus-specific T cell Responses
... NK cells or in the ratio of CD56 dim /CD56 bright in any of the patient groups or phases studied (data not ...NK cells differentiate into CD56 dim NK cells (26, ...
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High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
... 7. Cytokine stimulation overcomes NK cell education by inducing high mTOR activity that restores NKar ...positive cells among splenic NK cells from C57BL/6 or B2m / mice following 4 hr stimulation ...
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Rôle des cellules Natural Killer dans l'asthme allergique
... la cytokine à son récepteur, les protéines de la famille Jak qui lui sont associées s’activent, phosphorylant alors des résidus tyrosine présents sur les facteurs cytoplasmiques ...
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
... To determine whether cytokine stimulation enabled CDS+ T cells to respond to weak agonists, we pre-stimulated P14 cells with IL-21 in combination with IL-7 or IL-15 for 36[r] ...
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