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Copper and cobalt accumulation in plants: a critical assessment of the currentstatus of knowledge Bastien Lange, Antony van der Ent, Alan John Martin Baker, Guillaume Echevarria, Grégory Mahy, François Malaisse, Pierre Meerts, Olivier Pourret,
G U E S T E D I T O R I A L
Currentstatus of immunosuppressive minimization and tolerance strategies
Transplantation is the treatment of choice for end-stage renal disease. Its success relies on effective immunosuppres- sion to prevent allograft rejection. Previously, rejection rates were high, and graft loss due to rejection was frequent. As a consequence, we were taught over decades that a reduction in rejection rates is the main goal in transplanta- tion to improve outcomes. Despite dramatic reduction in rejection rates, long-term graft survival has not improved over the last decades, partly due to acceptance of more marginal donors. Today, graft loss due to acute rejection is low (<5%) and short-term patient and graft survival are excellent leading to different expectations for future drug regimens. Such regimens should aim to improve subopti- mal long-term outcomes, either by a reduction in the inci- dence of death with a functioning graft or by addressing the many causes of chronic allograft dysfunction (either immunologic or nonimmunologic).
2.2 History of online-coupled models developed in the US The currentstatus of a number of online models in Europe has been reviewed in Baklanov and Korsholm (2007) and Baklanov et al. (2007a). Most of the European online mod- els were developed in recent years, and very few of them are fully-coupled models that account for all major feedbacks. In this work, five online models on both regional and global scales developed in the US are selected to represent the currentstatus of online-coupled models worldwide and re- viewed in details. These models include one global-through- urban model, i.e., the Gas, Aerosol, TranspOrt, Radiation, General Circulation, Mesoscale, Ocean Model (GATOR- GCMOM) (Jacobson, 2001b, 2002, 2004a, b; Jacobson et al., 2004), one mesoscale model, i.e., the Weather Research and Forecasting/Chemistry model (WRF/Chem) (Grell et al., 2005; Fast et al., 2006), and three global models, i.e., the Community Atmospheric Model v. 3 (CAM3) (Collin et al., 2006a), the Model for Integrated Research on Atmospheric Global Exchanges version 2 (MIRAGE2); Textor et al., 2006; Ghan and Easter, 2006), and the Caltech unified GCM (Liao et al., 2003, 2004, 2006; Liao and Seinfeld, 2005). All these models predict gases, aerosols, and clouds with varying degrees of complexities in chemical mechanisms and aerosol/cloud microphysics. While GATOR-GCMOM, WRF/Chem, and MIRAGE represent the state-of-the-science online-coupled models in the world with many feedbacks accounted for, CAM3 and Caltech unified GCM represent the current transition of 3-D models from offline to online in which meteorology and chemistry are coupled and feed- backs among various processes are being accounted for. In the following section, history and currentstatus of the five models along with other relevant models developed in the US are reviewed.
A survey was made of fourteen Captains of Canadian vessels that operate in Canada’s Arctic to extract their thoughts on the currentstatus of operating in the Arctic and to help identify research needs. There was an overwhelming consensus that research on identifying multi-year ice was the top priority. Predictions of ice movement and ice pressure, and locations of large leads or polynya were also identified as important. There was a wide range of disparity on the amount of ice information that they receive on the Bridge of the vessel. There was a general consensus that improvements in interpretation of satellite imagery and better local detection of multi-year ice were top priorities.
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Titanium Powder Metallurgy Activities at IMI/NRC : CurrentStatus and Future Directions
Abstract. This paper describes the currentstatus of GALILÉE-1 that is the new verification and
processing system for evaluated data, developed at CEA. It consists of various components respectively dedicated to read/write the evaluated data whatever the format is, to diagnose inconsistencies in the evaluated data and to provide continuous-energy and multigroup data as well as probability tables for transport and depletion codes. All these components are written in C++ language and share the same objects. Cross-comparisons with other processing systems (NJOY, CALENDF or PREPRO) are systematically carried out at each step in order to fully master possible discrepancies. Some results of such comparisons are provided.
The currentstatus of the Canadian Construction Codes
Dr. Russell Thomas Résumé
Presented at the Symposium on Fire Research Development & Application in the 21 Century, 2000, Taiwan
In this paper I will outline the currentstatus of the Canadian Codes by taking a look at the development process that has taken place in Canada over the last six to ten years. In nearly all countries around the world the codes themselves are only one aspect of the complex system of regulation and control that impacts all aspects of construction. It is impossible to look at codes in isolation and many aspects of the Canadian political and governmental structure have acted to shape the structure and approach of the new Canadian Objective Based Codes System.
The production and acceleration of Radioactive Ion Beams (RIBs) is today an area of intense interest. The history and development of RIB facilities in Europe is presented, with discussion of both the “in-flight” and “ISOL” methods used at different laboratories. The currentstatus of present developments like the SPIRAL II facility at GANIL and the FAIR in-flight facility at GSI are briefly reviewed. Particular emphasis is given to the recent EURISOL Feasibility Study for a European ISOL facility, and the present EURISOL Design Study.
I give a brief overview of the currentstatus of some aspects of the Cosmic Lens All-Sky Survey, CLASS.
1 Who and What?
CLASS, the Cosmic Lens All-Sky Survey, is a collaboration between groups at the Jodrell Bank Observatory (UK), ASTRON (NL), the Kapteyn Astronomical Institute at the University of Groningen (NL), Caltech (USA), the University of Pennsylvania (USA) and NRAO (USA). It is a survey for
at-spectrum radio sources ( 0 : 5 for S
is the thermal gradient rate inside fuel pellet at z axial position along fuel pin and at current time t.
The new formulation of the fuel fragments relocation model has been adopted by the latest revision of GERMINAL V2, observing the benefits brought for the simulation of the fuel pins of the validation base. The choice of the thermal gradient as a driving parameter for fragments relocation leads to a better agreement with post-irradiation measurements, when considering quantities closely linked to the thermal regime undergone by the fuel pin, such as the columnar grains expansion diameter or the central hole diameter. The main benefits are observed at intermediate power level, i.e. at the fuel pin extremities or for objects which have operated at lower conditions than normal ones – PHÉNIX cycles at two third of nominal power. These results are obtained with a model calibration not depending anymore on the fuel pin type; the new formulation is thus more general than the original one.
FIG. 8. Prediction on the two dileptonic branching ratios B(B s → µµ) and B(B d → µµ) coming from the global fit (without input on dileptonic branching ratios) compared to current experimental information . B(B s → µµ) is shown removing the (1 + y s ) = 1.07 increase due to time integration. The NNLO computation in ref.  is indicated in colours, whereas the NLO computation used in ref.  is the region delimited by the dashed line. Regions outside the coloured areas are excluded at 1 − p > 95.45 %. The oval contours are the experimental 1, 2, 3 . . . σ confidence regions .
Objective: This study aims at assessing the status of obesity management in the European region and identifying future goals and objectives of professionals working in the field of obesity. Methods: Presidents of all 31 EASO-affiliated (EASO = European Association for the Study of Obesity) national associations for the study of obesity were asked to invite 5 obesity experts from their country to participate in a survey. A total of 74 obesity professionals out of 23 countries participated. Questions addressed the development of guidelines, the status of obesity management, and goals and objectives for the future in obesity management. Fur- ther, EASO’s three vice-presidents participated in in-depth, semi-structured interviews, in which they were asked to provide their reflection on the survey data. Results: Most countries define obesity as a clinical and chronic disease, but various differences in obesity manage- ment standards exist across Europe. Existing guidelines mainly focus on the acute treatment of obesity rather than on long-term approaches. Conclusion: Multidisciplinary approaches for obesity management and the collaboration between general practitioners and hospitals as well as between professionals at the local level and networks of obesity management cen- ters need to be improved across Europe. Good practices and evidence are available.
FIG. 1. One time step resolution by GERMINAL V2.
2.3. Code validation
The validation of GERMINAL V2 was carried out by using a selection of 100 SFR fuel pins. PHÉNIX standard geometry represents the major part of the validation base, with 45 fuel pins of internal core and 10 pins of external core. In addition, 15 SUPER-PHÉNIX 1 fuel pins with annular pellets of larger diameter and 3 PHÉNIX heterogeneous pins are of special importance considering the current design of ASTRID. The validation base also includes 8 transient tests operated in CABRI reactor, reproducing off-normal conditions such as power ramps, with different increase rates and peak levels, or Reactivity Insertion Accidents.
Ann Arbor, MI 48109, USA
* Correspondence: firstname.lastname@example.org; Tel.: +1-306-966-1960
Received: 9 June 2019; Accepted: 26 June 2019; Published: 30 June 2019
Abstract: Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.