common genetic variants
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
... of genetic variation on pathogen-sensing in primary human DCs We developed an integrated experimental and computational pipeline ...with common genetic ...with genetic variation to identify ...
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Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer
... whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation ...multiple variants associated with ...
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Common genetic variants influence human subcortical brain structures.
... of common variants influencing other complex quantitative traits such as height 7 and bodymass index 8 ...significant variants identified here showed specific effects on single brain structures ...
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Evaluation of the association between common genetic variants and breast cancer risk
... common form of genetic variation, has allowed a rapid evolution of approaches for studying common genetic susceptibility ...candidate variants in key genes, ii) to conduct more ...
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Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation
... as common feature of each group, the nitrogen transporters utilized by these amino acids, where the first group corresponded to amino acids transported by Gap1p, Agp1p and Gnp1p, while in the second group of amino ...
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Common variants in the region around Osterix are associated with bone mineral density and growth in childhood
... the genetic influences on adult BMD was recently advanced by two genome-wide association studies (GWAS) in which BMD was analysed in relation to ...shared genetic influ- ences on BMD in children and ...
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Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study
... CONCLUSIONS: The global and regional effects on brain morphometry due to 16p11.2 CNVs generalize across site, computational method, age, and sex. Effect sizes on neuroimaging and cognitive traits are comparable. Findings ...
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Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report
... site variants (online supplementary table 4) and (iii) novel RNA splicing assays (online supplementary table 4, figures 6A, B and ...site variants only if all predicted RNA product are bona fide LoF ...site ...
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Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
... most common form of glaucoma in the Western world, is an age-related, complex disease characterized by progressive irreversible degeneration of the optic nerve due to apoptotic retinal ganglion cell death ...
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DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases
... have common fea- tures, including autosomal-dominant inheritance (except X-linked spinal and bulbar muscular atrophy), genetic anticipation, neuronal involvement, and intracellular inclusions containing the ...
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Blood pressure and cerebral white matter share common genetic factors in Mexican Americans.
... more genetic overlap with PP and ...shared genetic variance was explained by the regional rates of cerebral ...significant genetic correlations were not observed between DBP and ...identify ...
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Three Common Intronic Variants in the Maternal and Fetal Thiamine Pyrophosphokinase Gene (TPK1) are Associated with Birth Weight
... coding variants in the TPK1 gene, we genotyped 43 non coding SNPs spanning a region of 420kb, and used the QTDT method to test their association with birth weight in 964 individuals from 220 families of European ...
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No evidence that common genetic risk variation is shared between schizophrenia and autism
... structural genetic variants are reported to increase the risk of both schizophrenia and autism spectrum ...shared genetic background based on rare genetic variants, common risk ...
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Phenotypic and genetic differentiation in young-of-the-year common sole () at differentially contaminated nursery grounds
... with genetic diversity has been poorly ...adaptive genetic differentiation in the European flounder (Platichthys flesus), as particular alleles/genotypes were correlated to proxies of fitness such as ...
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Investigation of genetic diversity and population structure of common wheat cultivars in northern China using DArT markers
... Results: In total, 1637 of 7000 DArT markers were polymorphic and scored with high confidence among a collection of 111 lines composed mostly of cultivars and breeding lines from northern China. The polymorphism ...
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Efficient algorithms for Longest Common Subsequence of two bucket orders to speed up pairwise genetic map comparison
... Abstract Genetic maps order genetic markers along ...facilitate genetic map comparisons. We propose to encode genetic maps by bucket order, a kind of order, which takes into account the ...
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Heterogeneity in the development of proactive and reactive aggression in childhood: Common and specific genetic - environmental factors
... behavioral genetic studies supporting familial effects on PA [ 52 , 56 ], as others did not [ 53 , 57 ...behavioral genetic studies, the present findings support effects of ...with genetic factors, a ...
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GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, “GENEREPOL study”: Lack of common variants with large effect sizes
... that genetic variants might explain a significant proportion of susceptibility to develop ...the genetic make-up favoring the occurrence of diLQTS remains ...of common mutations in the known ...
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Genetic variants involved in specialized DNA replication and their relation with breast cancer risk, disease progression and patient prognosis
... in genetic instability, which is a driving force of cancer cells from earlier stages of pathologenesis, are not fully ...to genetic instability, and also resistance to “replicative stress”, leading to ...
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Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.
... 3’UTR variants, *611T > A and ...3’UTR variants can affect mRNA stability and assessed the impact of all three variants on mRNA and protein ...3’UTR variants were associated with reduced ...
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