Circulating tumor Cells (CTCs)
Acoustic separation of circulating tumor cells
... Circulating tumor cells (CTCs) are important targets for cancer biology ...rare tumor cells from peripheral blood must be ...biological cells using label-free and contact- free ...
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eTumorType, an algorithm of discriminating cancer types for circulating tumor cells or cell-free DNAs in blood
... capturing circulating tumor cells (CTCs) and cell-free DNAs (cfDNAs) in blood, serum, and plasma [1–3] ...blood cells [4] , resulting in the generation of false negatives, false positives, or ...
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Biodegradable nano-films for capture and non-invasive release of circulating tumor cells
... of circulating tumor cells (CTCs) from whole blood is an important capability for both clinical medicine and biological ...isolated cells under excessive stresses that reduce cell viability, ...
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Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment
... Keywords: circulating tumor cells; hematological cells; neutrophils; platelets; liquid biopsy ...Introduction Circulating tumor cells (CTCs) have been extensively studied ...
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Circulating Antibodies to ALK Inversely Correlat with Relapse Risk and Circulating Tumor Cells in Children and Adolescents with ALK-Positive Anaplastic Large Cell Lymphoma
... of circulating tumor cells (CTCs) expressing nucleophosmin (NPM)-ALK-transcripts at diagnosis in bone marrow or blood confers an unfavourable prognosis ...
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“Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
... Abstract Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer. Migration of circulating tumor cells (CTCs) into the blood stream is an early event that occurs during ...
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Diagnostic and prognostic value of circulating tumor cells in head and neck squamous cell carcinoma: a systematic review and meta-analysis
... “circulating tumor cells”, “epithelial cells”, and “rare cells” variably combined with one of the following terms: “head and neck”, “squamous cell carcinoma”, “HNSCC”, “Nose”, “nasal ...
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Circulating Tumor Cells and Circulating Tumor DNA Detection in Potentially Resectable Metastatic Colorectal Cancer: A Prospective Ancillary Study to the Unicancer Prodige-14 Trial
... Keywords: circulating tumor cells; circulating tumor DNA; liquid biopsy; metastatic colorectal cancer; FOLFIRINOX 1. Introduction While most patients diagnosed with metastatic ...
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Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells
... these cells is yet to be established, they are not considered for enumeration in our ...CK-/CD45- cells among the captured putative CTCs ...nucleated cells (Table S2 in File ...EpCAM+/CK+ ...
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Profiling of circulating tumor DNA in plasma of non‐small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells
... tumoral cells (di- ameter greater than 15 µM) into ...200 cells (Figure ...five cells without spiking into total ...50 cells with the ...
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EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis
... including tumor cell migration or CTC survival [ 68 ...Cancer-Stem Cells (CSCs) [ 94 , 95 ], it is important to note that EMT induces the expression of stem cell attributes [ 96 , 97 ] and that certain EMT ...
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Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery
... to tumor invasion and ...malignant cells by either cytological features or by antigen detection using immunofluorescence or ...of cells with an epithelial phenotype thereby permitting the use of CTCs ...
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Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells.
... Captured cells were fixed and permeabilized with methanol before being processed for a triple immunostaining against vimentin, TF, and cytokeratins (antibodies listed in Supplementary Table ...
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EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis
... TGF-β-induced cells in vitro, and a mechanism has been proposed by which EMT-shifted CTC resistance to NK cells is increased [ 134 ...NK cells and an increased expression of different NKG2D ligands ...
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Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells
... of tumor cells from the primary tumor and/or metastases is deleterious for the patient, it also becomes an opportunity to obtain relevant information for precision medicine using a noninvasive ...
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Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells
... encapsulation of arrested CTCs occurs by the formation of endothelial domes, reminiscent of the ones observed for extravasation of neutrophils 54 and of leukocytes 55 , that are tightly connected through EC-EC junctions ...
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Combination of mechanical and molecular filtration for enhanced enrichment of circulating tumor cells
... isolate cells based on both molecular and mechanical ...cancer cells on magnetic beads conjugated with anti- EpCAM, rinse, and then capture the cells with beads on a filter, and finally detach them by ...
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Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes
... Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment efficacy. However, CTC investigation is hampered by their low number, making the establishment of ...
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[Circulating tumor cells and breast cancer: detection techniques and clinical results]
... Le nombre total de patientes (N pts) correspond à l’ensemble des patientes étudiées dans la publication, tout stade confondu : dans les publications étudiant plusieurs stad[r] ...
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Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials.
... Box 1 Clinical settings and endpoints The different trials presented above are using commonly accepted endpoints to judge whether a treatment or a strategy is clinically relevant. Two settings must be clearly separated; ...
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