circulating tumor cells clusters
Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment
... Keywords: circulating tumor cells; hematological cells; neutrophils; platelets; liquid biopsy ...Introduction Circulating tumor cells (CTCs) have been extensively studied ...
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Circulating Tumor Cell Clusters: United We Stand Divided We Fall
... the clusters. In particular, methods with visible cells at the end point are more relevant for their identification than methods based on CTC enrichment followed by molecular identification at ...CTC ...
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Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery
... to tumor invasion and ...malignant cells by either cytological features or by antigen detection using immunofluorescence or ...of cells with an epithelial phenotype thereby permitting the use of CTCs ...
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Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells
... liver tumor are first disseminated in microscopic portal vessels, and then in the centrolobular veins that drain into the main hepatic ...(or clusters). In addition, high detection rate of CTCs or ...
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eTumorType, an algorithm of discriminating cancer types for circulating tumor cells or cell-free DNAs in blood
... into clusters based on criterion of sim- ilar average number of GO-based ...two clusters with the highest and lowest average num- bers were taken as the most similar and the most dissimilar cancer type ...
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EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis
... in clusters is so far largely uncovered, it is nevertheless recognized that CTC clusters contain hybrid E/M ...in clusters, such as plakoglobin, which has been further shown to be functionally ...
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EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis
... in clusters is so far largely uncovered, it is nevertheless recognized that CTC clusters contain hybrid E/M ...in clusters, such as plakoglobin, which has been further shown to be functionally ...
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Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes
... CTC clusters (<2 to 13 ...3 clusters of 2 CTCs/microemboli): ...single cells and clusters in the first samples, and as single cells in the last sample at the time of the third ...
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Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells
... of tumor invasion and ...that clusters of CTCs, whose arrest would be favored by physical occlusion, are more potent in driving tumor metastasis 45–47 ...
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Plasma Circulating Tumor DNA in Pancreatic Cancer Patients Is a Prognostic Marker
... Somatic mutations were analyzed in plasma DNA samples by NGS without any information on primary tumor mutational status. All KRAS mutations were also validated with picoliter droplet digital PCR that provides both ...
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Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
... Immunofluorescence Tumor pieces were fixed overnight with Periodate-Lysine-Paraformaldehyde [48] at 4°C and Immunofluorescence on tumor slices was performed as previously described [17, ...dying ...
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Acoustic separation of circulating tumor cells
... Circulating tumor cells (CTCs) are important targets for cancer biology ...rare tumor cells from peripheral blood must be ...biological cells using label-free and contact- free ...
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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
... of tumor cells, which are actively prolif- erating and require higher quantities of growth factors and nutrients than healthy ...toward tumor cells induces immunogenic cross-presentation of ...
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Profiling of circulating tumor DNA in plasma of non‐small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells
... correlation, the NGS‐56G assay failed to detect the EGFR p.T790M in 18/37 patients harboring the EGFR p.T790M at low MAF level. Nevertheless, the NGS‐56G technology offered a better coverage of EGFR gene mutations, ...
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The challenges of detecting circulating tumour cells in sarcoma
... Cancer cells that have escaped from the primary tumor are able to invade into surrounding tissues, to intravasate into the bloodstream to become circulating tumor cells (CTCs), and are ...
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Diagnostic and prognostic value of circulating tumor cells in head and neck squamous cell carcinoma: a systematic review and meta-analysis
... the recurrence/metastasis rate in the CTC-positive patients was significantly higher compared to patients without disease progression, suggesting that the detection of CTC in patients with squamous cell carcinoma of the ...
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Rheology and Magnetolysis of Tumor Cells
... cancer cells have been ...of cells since it can be applied locally and it is possible to obtain some map of the viscoelastic properties of the membrane and its supporting actin ...cancer cells, ...
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Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.
... of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and ...
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Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
... When tumor volumes ranged from 60 to 200 mm 3 , seven mice were allocated to five groups to obtain groups with homogeneous mean and median tumor ...recorded. Tumor volume was evaluated with a caliper ...
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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.
... B cells, including both the isotype-switched and the + IgM IgD CD27 B cells, in accordance with Kruetzman et ...B cells, implying that there may be large variations among + + + these younger ...these ...
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