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Chromatin structure

Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction

Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction

... (Sag), guanylate cyclase activator (Guca), recoverin (Rcvrn), and peripherin 2 (Prph2). Five distinct housekeeping genes (Ppia, Gapd, Arbp, Tuba1, and Hprt) showed no differential expression between R7E and WT mice (see ...

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Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

... TTC7A de ficiency results in genome instability and impaired cell survival A change in nucleosome organization can potentially affect genome stability because naked or non- nucleosomal DNA is more prone to induction of ...

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Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells

Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells

... DISCUSSION ESCs and iPSCs have been shown to share key features of pluripotency, including expression of pluripotency markers, tera- toma formation, cell morphology, ability to differentiate into germ layers, and ...

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CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

... some-like structure on DNA ( Figure 6 ...associated chromatin is different from that of DNA isolated by CENP-A immunoprecipitations ( Hori et ...CENP-T-containing chromatin structure in ...

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Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

... (Sag), guanylate cyclase activator (Guca), recoverin (Rcvrn), and peripherin 2 (Prph2). Five distinct housekeeping genes (Ppia, Gapd, Arbp, Tuba1, and Hprt) showed no differential expression between R7E and WT mice (see ...

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Large Scale Chromosome Folding Is Stable against Local Changes in Chromatin Structure

Large Scale Chromosome Folding Is Stable against Local Changes in Chromatin Structure

... small-scale chromatin structure and large-scale chromo- some folding during interphase is a prerequisite for understanding ...of chromatin sequences com- posed of alternating blocks of fibers with ...

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Livestock genome annotation: transcriptome and chromatin structure profiling in cattle, goat, chicken and pig

Livestock genome annotation: transcriptome and chromatin structure profiling in cattle, goat, chicken and pig

... of chromatin in the four species We used ATAC-seq to profile the accessible chromatin of liver and of CD4+ and CD8+ immune cells in animals from the four ...

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Rearrangement Scenarios Guided by Chromatin Structure

Rearrangement Scenarios Guided by Chromatin Structure

... In previous work, we developed algorithms to use this 3D structure to guide the computation of rearrangement scenarios. We sought out local scenarios, rely- ing on a partition of the adjacencies such that each ...

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Chromatin structure of the inactive X chromosome

Chromatin structure of the inactive X chromosome

... The second focus of this thesis is the nature of the association between XIST RNA and the Xi chromatin. Microscopy studies have shown that the noncoding XIST RNA [r] ...

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Biased chromatin signatures around polyadenylation sites and exons

Biased chromatin signatures around polyadenylation sites and exons

... Polyadenylation sites are strongly depleted of nucleosomes Previous work has suggested connections between transcript termination, chromatin structure and histone modification (Lian et al., 2008). ...

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A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture

A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture

... its chromatin structure and the deposition of RNA polymerase II and specific histone ...linking chromatin remo- delers to CK signaling and cell cycle ...a chromatin loop through the action of ...

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

... of chromatin, and it is likely that modulation of chromatin structure plays a role in DDR ...of chromatin modulation in the DDR is ...of chromatin modulation in the DDR, we developed a ...

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Chromatin Boundaries and Chromatin Domains

Chromatin Boundaries and Chromatin Domains

... This series of investigations also has revealed a lot about the role of chromatin structure in regulating gene expression. The analysis of the developmentally regu- lated distribution of histone ...

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CpG island structure and trithorax/polycomb chromatin domains in human cells

CpG island structure and trithorax/polycomb chromatin domains in human cells

... TrxG/PcG chromatin structure and local CpG content We compared the genome-wide location of CpG islands to the occupancy of H3K4me3 and H3K27me3 modified nucleosomes for a collection of cells using data from ...

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The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.

The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.

... of chromatin (1) are known since a few decades to be the nucleic acid (DNA) bearing the genetic information, and the four different histones (H2A, H2B, H3, H4) arranged by pairs into an ...of chromatin ...

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Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions

Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions

... kb chromatin loop formed between Su(Hw) insulators (orange) could decrease E-P interactions (red ‘‘X’’) ...kb chromatin loop in the region between enhancer and promoter was proposed to increase E-P ...

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BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

... and chromatin was sheared using a Misonix 3000 sonicator (Misonix) at the following settings: 10 cycles, each for 30 s on, followed by 1 min off, at a power of approximately 20 ...

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Chromatin regulation at the frontier of synthetic biology

Chromatin regulation at the frontier of synthetic biology

... of chromatin states and subsequent analyses of their effects on many biological processes, including cellular differentiation, proliferation and ...probe chromatin dynamics at unprecedented spatiotemporal ...

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ChromHMM: automating chromatin-state discovery and characterization

ChromHMM: automating chromatin-state discovery and characterization

... chromatin state segmentation in dense view (single color-coded track), or expanded view (each state shown separately) ...of chromatin states across multiple cell types. When the chromatin marks are ...

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Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

... in chromatin accessibility observed in our reprograming system are accomplished in a replication- independent ...Open chromatin peaks were also enriched at enhancers for MEFs before NT, but this enrichment ...

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