Cerebral malaria
Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction
... malaria in 2017, 91% of whom were residents of sub-Saharan ...treatment. Cerebral malaria (CM) is one of the most severe forms of disease with a complex ...
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Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria
... clinical malaria relies on a handful of drugs, the most potent being artemisinin derivatives (called the artemisinins or ADs), a group of structur- ally related molecules that includes artesunate (ART), artemether ...
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Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model.
... Wiese et al. [42] found apoptosis of neurons as well as apoptosis of endothelial cells in the brains of mice with ECM in terminally ill animals, with clear clinical signs of cerebral involvement on days 10-13 ...
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Disentangling complex parasite interactions: Protection against cerebral malaria by one helminth species is jeopardized by co-infection with another
... of cerebral malaria using logistic regression analysis, correcting for co-infection status with analysis of deviance and explicitly including all possible interactions terms in the ...
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Differential expression of CD31 and von Willebrand factor on endothelial cells in different regions of the human brain: potential implications for cerebral malaria pathogenesis
... severe malaria infection revealed the highest number of cerebral complications among individuals 70 years old and older [ 33 ...In cerebral malaria, hemorrhages associated with an increase in ...
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Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding
... mild malaria (UM), severe malaria (SM) or cerebral malaria (CM) at the time of their admission to the clinic and from convalescent-phase sera collected 30 days after anti- malaria ...
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Young Sprague Dawley rats infected by Plasmodium berghei: A relevant experimental model to study cerebral malaria
... Abstract Cerebral malaria (CM) is the most severe manifestation of human malaria yet is still poorly ...bral malaria model with an experimental Plasmodium berghei Keyberg 173 (K173) infection ...
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A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria
... The IL22 variants rs1012356 and rs2227476 are associated with childhood cerebral malaria. We selected 46 TagSNPs within the IL22 and IL22RA2 genes and a 5 kb region upstream and downstream from these two ...
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Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders
... Mali Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and ...with cerebral or uncomplicated ...
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Parasite genetic factors implicated in cerebral malaria
... of malaria, resulting in over or under estimation of the binding properties of parasites to their cognate receptor, if any ...Thus, cerebral malaria isolates drawn from peripheral blood at the time ...
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Malaria and Education: Evidence from Mali
... If cerebral malaria is rare at this stage, “simpler” cases of clinical malaria (called “uncomplicated malaria”), in addition to repeated illness or chronic malaria infections, are ...
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Bayesian Modeling of Cerebral Information Processing
... degenerative cerebral lesions, as well as the assessment of rehabilitation procedures, necessitate knowing the cerebral substratum of cognitive or sensorimotor ...connected cerebral regions ...
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Monitoring of malaria vectors at the China-Myanmar border while approaching malaria elimination
... potentiating malaria trans- mission should not be ...of malaria parasites, ...a malaria vector [ 19 ...of malaria transmission by this species in ...
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Cerebral modeling and dynamic Bayesian networks
... 2.2. Cerebral nodes and their representations In the light of the preceding paragraph, the whole brain can be viewed as a very complex large-scale network, composed of interconnected and overlapping, function- ...
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Data on Social Network Analysis on Malaria
... bernard.dousset@irit.fr Abstract - In order to understand the existent and in formation relationships that might surface from scientific publications it is necessary to use methods for data and network analysis, besides ...
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Patterns of anemia during malaria
... during malaria Dear Editor, We read with interest the article by Rehman et ...for Malaria Venture (MMV) in March 2013 in Vienna ( ...the malaria community to adapt rapidly and efficiently to new ...
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The Summary Index of Malaria Surveillance (SIMS): a stable index of malaria within India
... For each of the above PCA analyses, we expected the first PCA axis, which explains the most variation, to be the one of interest. Thus, after assessing the variance that the first PCA axis explained and confirming that ...
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Relationship between cerebral amyloid burden and cerebral microstructure measured by quantitative MRI in healthy aging
... The finding that increased iron in frontoparietal and occipital areas are associated with increased amyloid burden fits with previous studies. However, current results also indicate that individuals with higher cortical ...
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On the normalization of cerebral blood flow
... INTRODUCTION Cerebral blood flow (CBF) is a key parameter for quantifying normal, altered, or pathologic brain functioning, both in medical current practice and in cognitive neuroimaging ...
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Mapping Malaria Risk in Dakar, Senegal
... of malaria risk on a fine scale, we have constructed two indicators which correspond respectively to the hazard and the vulnerability in the case of this ...
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