Cell type
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures
... investigated cell-type-specific transcrip- tomic signatures in the mouse striatum ( Gokce et ...specific cell types in the mouse striatum, covering dSPNs, iSPNs, astrocytes, and ...the ...
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Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
... neuronal cell type affects pro- cessing of APP by a-, b-, and g-secretases, as well as the responsiveness of different neuronal subtypes to ...different cell fates respond differentially to soluble ...
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Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits
... A preferential connection from CA2 to deep CA1 pyramidal cells establishes a novel trisynaptic circuit: DG-CA2-CA1 deep Previous studies using classical anatomical criteria showed that CA2 projects to CA1 8, 9, 21, 39 ...
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Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
... new cell type, one would expect to see a halving of TRAP yield with half the amount of matrix used in TRAP purifications -- and no detectable purification of RNA from the non- TRAP control with either ...by ...
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Cell-Type-Specific Synchronization of Neural Activity in FEF with V4 during Attention
... The selective coupling of FEF visual neurons with V4 during sustained attention adds further evidence to the distinct contri- bution of FEF visual neurons to attentional mechanisms. Our finding that enhanced coupling ...
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Cell type-dependent control of NF-Y activity by TGF-β
... Institut de Ge´ne´tique Mole´culaire de Montpellier, CNRS-UMR5535-IFR122, Montpellier, France Transforming growth factor b (TGF-b) is a pluripotent cytokine that regulates cell growth and differentiation in a ...
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Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
... DISCUSSION We employed a BAC transgenic strategy to express ChR2-EYFP under the endogenous promoter elements that define the GABAergic, cholinergic, serotonergic, and Pvalb+ subtype of neurons throughout the CNS. While ...
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CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus.
... Modeling cell type-specific interactions between CTCF sites To address the issue of whether differential cell type- specific CTCF contacts affect the conformation of the globin region, a ...
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Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles
... B cell follicles but aggregated in small and compact B cell follicles centered around few CXCL13 + FDC-M2 + RFP + cells (Figure 5B and unpublished ...B cell follicles provided a unique opportunity to ...
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Compartment and cell-type specific hypoxia responses in the developing Drosophila brain
... reveals cell-type specific hypoxia states in central brain and optic ...for cell-type specific markers (gray): (A) anti-Deadpan (neuroblasts, NB), (B) anti-Prospero (ganglion mother cells, ...
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Cell-type specific determinants of NRAMP1 expression in professional phagocytes
... on cell type(s) in which they were found these DNA-protein associations may occur at different stages of, or be maintained through, the myelo-monocytic differentiation ...
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex
... harbor mutations that associate with human brain disorders such as microcephaly and autism (Figure 2J–2M and below), suggesting cell type-specific mechanisms of human diseases. Alternatively Spliced Exons ...
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Cell-type Specific Optogenetic Mice for Dissecting Neural Circuitry Function
... neuron. Cell-attached recordings were performed in some experiments to monitor action potential firing without disruption of the ...cytosol. Cell-attached recordings were performed in voltage clamp mode ...
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Cell-type and endocannabinoid specific synapse connectivity in the adult nucleus accumbens core
... The nucleus accumbens (NAc) is a mesocorticolimbic structure that integrates cognitive, emotional and motor functions. Although its role in psychiatric disorders is widely acknowledged, the understanding of its circuitry ...
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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
... Tissue handling and staining. Mice used for all experiments were sacrificed by an iso flurane (Baxter KDG9623) overdose, mandibles were carefully dissected out, fixed in 4% paraformaldehyde pH 7.4 for 5–15 h, decalcified in ...
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
... whole cell images were obtained with ...each cell and multiplying by the following: median total dendritic length for treatment group – (30 * median number of primary dendrites for treatment ...
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Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming
... A. Gaignerie 1 , N. Lefort 2 , M. Rousselle 1 , V. Forest-Choquet 3 , L. Flippe 4,5,6 , V. Francois–Campion 4,5,6 , A. Girardeau 3 , A. Caillaud 3 , C. Chariau 1 , Q. Francheteau 1 , A. Derevier 1 , F. Chaubron 7 , S. ...
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Cell-type specific contributions to Rett Syndrome : neuronal and astrocytic signaling and sensory processing
... With these emerging findings we have provided additional evidence for the role of astrocytes in Rett pathophysiology by showing that MeCP2: (1) regulates astrocyte signaling p[r] ...
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Cell-type specific cholinergic modulation of the cortex
... Specifically, the cholinergic innervation of the neocortex by afferent fibers originating in the nucleus basalis (NB) of the basal forebrain (3) was found to be im[r] ...
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Role of ETS1 in the transcriptional network of diffuse large B cell lymphoma of the activated B cell-like type
... B- cell transcriptional program but also in RNA ...TMD8 cell line, this suggests that cell-type dependency and other factors could be involved in regulating these ...
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