cell receptor
A Bayesian framework for high-throughput T cell receptor pairing
... A Bayesian framework for high-throughput T cell receptor pairing The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Holec, ...
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The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate
... non-T cell lineage capacity of the progenitors and eventually establish the T-cell ...T-cell receptor (TCR) αβ heterodimer on their cell surface that can recognize foreign or ...
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IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
... T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR ...T cell activation and survival after suboptimal TCR activation, as mice ...
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Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
... In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self- antigen affinity. We show ...
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Comment on “Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination”
... T-cell receptor (TCR) repertoire analysis has clearly gained the status of a major tool to profile the immune response in health and ...T cell subsets, it still remains problematic to assign a clear ...
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Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
... thought to depend on ligand-induced aggregation, continuous BCR expression is needed for survival of healthy B cells, 6,7 and signal to maintain survival in the absence of receptor engagement. 7,8 Crosslinking of ...
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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation
... The interaction between the TCR and MHC-peptide complexes leads to the initiation of TCR signaling and represents a key step for the orchestration of the adaptive immune response. Indeed, the intracellular signaling ...
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Plasmodium P36 determines host cell receptor usage during sporozoite invasion
... In conclusion, our study reveals that host CD81 and SR-BI define two alternative pathways in human cells for sporozoite entry. Most importantly, we identified the parasite 6-cysteine domain pro- tein P36 as a key ...
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Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus
... In vivo influenza infections 8-10 week old male mice were anesthetized by a single dose of avertin (1.25% tribromoethanol, GIBCO), 250 mg/kg body weight, delivered by intraperitoneal injection. A/WSN/33 (2×10ˆ 5 ...
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Numerical Modelling Of The V-J Combinations Of The T Cell Receptor TRA/TRD Locus
... 1 CNRS, Laboratoire TIMC-IMAG, UMR 5525, Grenoble, France, 2 INSERM, Institut Albert Bonniot, Grenoble, France, 3 Universite´ Joseph Fourier-Grenoble I, Faculte´ de Me´decine, Grenoble, France Abstract T-Cell ...
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Cloning and comparative analysis of the human pre-T-cell receptor a-chain gene
... Amino acid sequence comparison of human pTa with the mouse pTa molecule reveals high sequence homology in the extracellular as well as the transmembrane region.. In contrast, the cytopla[r] ...
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Analysis and expression of a cloned pre-T cell receptor gene
... A glycosylated chain of 33 kD (gp33) is paired with TCRP proteins in a TCR,-transfected immature T cell line (SCB.29) from severe combined immunodeficient (SCID) mice (12), but could not[r] ...
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γδ T cell receptor ligands and modes of antigen recognition.
... T cell receptors for antigens contribute to all aspects of immune responses, including defenses against viruses, bacteria, parasites and tumors, allergy and ...on cell surfaces, implying diverse modes of ...
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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.
... ligation (lane 1 compared to lane 4) and treatment with dasatinib (100nM) completely blocked this effect while SP600125 that affect JNK did not. Similarly, PP2 decreased BCR-induced phospho-Tyr397 LYN in pri- mary MCL ...
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RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor
... DISCUSSION The translation of tumor-reactive Vg9Vd2 T cells to clinical appli- cations has proven challenging, due to a limited understanding of the molecular mechanisms by which Vg9Vd2 T cells recognize their targets. ...
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Trimeric structure of the mouse Kupffer cell C‐type lectin receptor Clec4f
... lectin receptor Clec4f has been identified as a specific surface marker for Kupffer cells, although its ortholog is absent in humans and its biological func- tion remains ...Kupffer cell receptor; ...
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CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
... T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...following cell surface encounter, but it promoted the subsequent ...
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Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center
... stem cell transplantation (alloSCT) has first highlighted the potential of T cells to eliminate cancer ...T-cell receptor (TCR) coupled with one or more co-stimulatory domains, allowing to transduce ...
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Endothelial cell protein C receptor and the risk of venous thrombosis.
... endothelial cell receptor present in many cells and ...endothelial cell receptor specific for PC -- the endothelial cell protein C receptor (EPCR)-- which increases the PC ...
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Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse
... ing an available pool of pS727STAT1 to prime circulating Thp for rapid activation of STAT1driven gene expression. Cytokine receptor exclusion from the IS IL4R–STAT6 signaling induces the exclusion of the IFNGR ...
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