CD4+ T cells depletion
P19-25. A vaccine model to prevent the depletion of uninfected bystander CD4 cells during HIV infection
... The CD4 depletion in the chronic phase of HIV infection is mostly due to the loss of uninfected ...non-infected CD4 cells from HIV-infected ...bystander CD4 cells could be ...
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Prognostic role of CD4 T-cell depletion after frontline fludarabine, cyclophosphamide and rituximab in chronic lymphocytic leukaemia
... EOT CD4 count was not associated with an increased risk of infection, which means that a CD4 cell count is not useful to manage anti-viral or microbial prophylaxes, in clinical practice (the 200/mm 3 ...
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Population dynamics of CD4+ T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency syndrome (MAIDS).
... dividing cells in a few hours. Therefore, cell depletion observed afterwards reflected cell turnover in the absence of replenishment from the cycling pool [26, ...of CD4 + T-cells in the LN of ...
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en fr Study of the transcriptional regulation of CD4 T cells in cancer : potential application in antitumor immunotherapy Etude de la régulation transcriptionnelle des lymphocytes T CD4 dans un contexte de cancer : application en immunothérapie anticancéreuse
... B16-OVA cells or 4 × 10 5 LLC-OVA cells were injected intravenously into ...node cells from B16-F10 tumor–bearing mice were labeled with the following antibodies: anti-CD4 ...and cells ...
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CD4 + T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity
... as CD4 + T cell depletion impaired the increase in spontaneous (s) and miniature (m, recorded in the presence of TTX) synaptic activities in EE, compared to ...
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OA031-05. HIV escape from natural killer cytotoxicity: Nef inhibits NKp44L expression on HIV-infected CD4+ T cells
... progressive depletion of unin- fected CD4 ...both CD4 depletion and increase in viral load. NKp44L+CD4+ cells are highly sensitive to the NK lysis ...HIV-infected cells ...
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CD4+ T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity
... as CD4 + T cell depletion impaired the increase in spontaneous (s) and miniature (m, recorded in the presence of TTX) synaptic activities in EE, compared to ...
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The relationship between CD4+CD25+CD127- regulatory T cells and inflammatory response and outcome during shock states.
... To further evaluate the role of Tregs on sepsis out- come, we used a well characterized CLP model of poly- microbial sepsis in mice. In accordance with Scumpia and colleagues [12], we observed a rapid increase in Tregs ...
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Regulation of B cell responses by distinct populations of CD4 T cells
... Tfh cells, Tfr cells express both Blimp-1 and Bcl-6, which are known to suppress each other [20] [ ...Tfr cells. While Id2 and Id3 depletion in Treg cells resulted in increased Tfr cell ...
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HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial
... and CD4 + T-cell ...mediated CD4 + T-cell depletion, we immunised simian HIV (SHIV)- infected macaques with a 3S-based ...of CD4 + T cells from death and decreased immune activation and ...
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Indicators of Antarctic ozone depletion
... total column ozone which show little change through the 1990s, the ozone mass deficit shows significant growth dur- ing the 1990s, almost doubling in value from 8.6×10 9 kg in 1990 to 15.2×10 9 kg in 2000. This results ...
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Modulation of HIV-1 replication in primary dendritic cells in contact with autologous CD4 T-lymphocytes
... Methods DCs were generated from human blood CD14 + mono- cytes. After 2 hours of incubation with HIV-1, DCs were added to autologous primary CD4 T-lymphocytes. The percentage of infection was quantified by flow ...
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P17-04. Targeting HIV peptides to human dendritic cells via CD40 elicits expansion of multi-epitope polyfunctional CD4+ and CD8+ T cells in HIV patients
... * Corresponding author Background Targeting Dendritic Cells (DCs) with anti-DC receptor antibody-antigen fusion proteins represents a novel approach to vaccine development. In mouse models, these innovative ...
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ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+T cells by plasmacytoid dendritic cells
... ICOS constitutes a critical regulator of humoral immune responses, mainly as it stimulates follicular helper T cell activa- tion, as illustrated in ICOS-deficient mice and patients. This said, a few reports also suggest ...
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Cord Blood Glutathione Depletion in Preterm Infants: Correlation with Maternal Cysteine Depletion
... The first interesting finding in the current study was a significant reduction in maternal [GSH] in the case of preterm delivery. The effect of pregnancy on GSH status is debated, and published data concerning maternal ...
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
... stem cells MSCs were isolated from eight- to ten-week-old C57BL/ 6 ...marrow cells were collected by flushing fe- murs and tibias and the cell suspension (1 × 10 6 cells/cm 2 ) was plated in a ...
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HIV‐1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells
... Jurkat CD4 T cell line expressing, or not, HA-Vpr, by counting the number of LC3 dots per ...in cells expressing HA-Vpr (red cells) whatever the conditions used, ...i.e. cells treated by To, ...
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en fr TO STUDY THE ROLE OF CD4+ SAMHD1low MEMORY CELLS IN HIV-1 INFECTION Caractérisation et rôle des lymphocytes T CD4+ mémoires SAMHD1low au cours de l'infection par le VIH-1
... receptor CD4 and the membrane-spanning co-receptor CC-chemokine receptor 5 (CCR5) (step 1), leading to fusion of the viral and cellular membranes and entry of the viral particle into the cell (step ...
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Actualité sur les lymphocytes T régulateurs CD4+
... régulateurs CD4 + Aurélie Siri 1 , Hubert de Boysson 1 , Guilaine Boursier > Les lymphocytes T régulateurs (Treg) CD4 + sont impliqués dans le maintien de la tolérance péri- phérique et la prévention des ...
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CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas
... surgery and intravital imaging Mice pancreas was exteriorized by surgery as described ( 25 ). Briefly, animals were anesthetized by injection of ketamine/xyla- zine (0.1/0.02 mg/g). Respiration was controlled by ...
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