CD4+ and CD8+ T cells
P17-04. Targeting HIV peptides to human dendritic cells via CD40 elicits expansion of multi-epitope polyfunctional CD4+ and CD8+ T cells in HIV patients
... T cells. The range of antigen-specific T cells recall responses over the 5 HIV peptide regions varied for each patient, but in sum epitopes from all 5 regions could be effectively processed and ...T ...
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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
... T cells that do not express either CD4 or CD8 co-receptor provided proof-of-concept for MHC-independent modes of T cell activation (Porcelli et ...(iNKT) cells recognize lipids presented by ...
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A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells
... these cells, despite potential arrest of viral genome ...mutant and attenuated viruses ( 50 , 81 ). Data recently reported by others and data from our group support this notion (Retamal-Díaz et ...T ...
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The IL‐27/IL‐27R axis is altered in CD4 + and CD8 + T lymphocytes from multiple sclerosis patients
... in CD4 + and CD8 + T lymphocytes As T lymphocytes play a central role in the pathobiology of MS 1,33 and that these cells can respond to IL-27, 6 we examined the broad impact of this ...
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en fr Immunological parameters in chronic viral hepatitis: evaluation of CD4+ and CD8+ specific T cells response during chronic viral hepatitis C. Paramètres immunologiques dans les hépatites virales chroniques: évaluation des réponses lymphocytaires spécifiques CD4+ et CD8+ au cours de l'hépatite virale chronique C
... lymphocytes CD4 + (< 15,5) étaient corrélés avec l’apparition d’une réponse soutenue (Shirakawa, Matsumoto et ...T CD4 + et CD8 + (Radziewicz, Ibegbu et ...T CD4 + ou CD8 + qui est ...
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Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution
... −/− and IL- 27R −/− animals to dissect the relevant contributions of donor and recipient ...mortality and augmented accumulation of proinflammatory T cells, whereas transplantation of ...
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CMV+ Serostatus Associates Negatively with CD4:CD8 Ratio Normalization in Controlled HIV-Infected Patients on cART
... of CD4+ and CD8+ T cells after cART initiation remains ...cART, and for whom CMV serostatus was available. Five hundred and three patients ful- filled the selection criteria (74% ...
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Immunogénétique et développement des lymphocytes T CD4-CD8- immunorégulateurs chez la souris
... 14.5 and thereafter, while both CD4 + T and CD8 + T cells could be detected as early as embryonic day ...2 and S2), demonstrating that tDN T cells appear early in T cell ...
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Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution
... BM and spleen cells, and then treated with an anti-IL-27p28-specific antibody on days 0 and ...recovery and overall survival (47% versus 0% survival at day 60, ...proinflammatory ...
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Cyclophosphamide inhibits the generation and function of CD8(+) regulatory T cells
... T cells (Treg) and CD4 ⫹ CD25 ⫹ Treg infiltrate human cancers, thus favoring tumor immune ...counteracting CD4 ⫹ CD25 ⫹ Treg ...human CD8 ⫹ ...inhibited CD8 ⫹ Treg generation ...
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Function of the immunoregulatory CD4-CD8- T cells in the context of autoimmune diabetes
... T cells as well as the therapeutic potential of these cells in the prevention of autoimmune diabetes in the non-transgenic ...proportion and cell number of DN T cells than diabetes-susceptible ...
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Human and Mouse CD8+CD25+FOXP3+ Regulatory T Cells at Steady State and during Interleukin-2 Therapy
... surface and intracellular markers and FOXP3 expression in mice Fresh total cells from the respective tissues were directly stained with the following monoclonal antibodies (mAbs) at prede- termined ...
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The V$_\beta$ 17$^+$ T cell repertoire: skewed J$\beta$ usage after thymic selection; dissimilar CDR3s in CD4$^+$ versus CD8$^+$ cells.
... Consequently, one side of the loop (and in particular, positions (3, 4, and 5) would seem to be much more variable than the other; perhaps the two sides interact with distinct[r] ...
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The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate
... transcription and translation [268, 320]. Lineage and stage specific ThPOK expression suggested a silencer/enhancer-driven regulation of ...stage and lineage specific ThPOK expression in developing ...
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CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
... modifying CD8-MHC interactions has an essentially proportional effect on the re- cruitment of Lck and, thus, on the earliest signaling ...of CD8 in ζ-chain phosphorylation (30), it was found (29) ...
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Exploration fonctionnelle des réponses cellulaires T CD4+ et CD8+ dans l’infection par le VIH-1
... antigens and are rendered anergic. The intricate balance between positive and negative signals delivered by accessory molecules is crucial to attaining effector immune responses while maintaining tolerance ...
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Contrasted TCRβ diversity of CD8+ and CD8- T cells in rainbow trout
... IL-21 and IL-22 and plays a key role in ...memory and effector memory T cells persist in the memory pool to provide systemic immune surveillance in secondary lymphoid and in ...
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en fr Characterization of memory CD8+ T cells generated in sterile inflammatory conditions Caractérisation des lymphocytes T CD8+ générés en conditions inflammatoires stériles
... damage and we show in this study that peptide immu- nization of F5 mice induces massive T cell ...disorders and promote Th2 responses (37, 38) could also play a ...of CD4 help in the synchronous T ...
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CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas
... surgery and intravital imaging Mice pancreas was exteriorized by surgery as described ( 25 ...(Bluesil) and pinned using stainless steel minutien insect pins (tip = ...lymphocytes and beta ...
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Alloantigenic recognition properties of CD8+ regulatory T cells
... rejection and donor strain transfusion-induced tolerance of heart allografts in adult ...Indirect CD4+ TH1 response, antidonor antibodies and diffuse C4d graft deposits in long-term recipients ...
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