cancer metastasis
TGFBI modulates tumour hypoxia and promotes breast cancer metastasis
... Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and ...
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Prediction of Early Breast Cancer Metastasis from DNA Microarray Data Using High-Dimensional Cox Regression Models
... breast cancer metastasis common to the genomics platforms used in the van’t Veer’s, van de Vijver’s, and Desmedt’s datasets, to define genomic predictors applicable in their entirety on the two external ...
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Treating cancer stem cells and cancer metastasis using glucose-coated gold nanoparticles
... cells, cancer stem cells and metastatic cancer cells grow in a non-attached (suspension) form when moving from their source to other locations in the ...nature, metastasis is often first detected in ...
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Role of the microtubule-associated protein ATIP3 in cell migration and breast cancer metastasis
... Abstract Metastasis, a fatal complication of breast cancer, does not fully benefit from available ...of cancer metastasis, we show that ATIP3 expression delays the time-course of metastatic ...
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Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche
... An abundance of clinical and experimental evidence has suggested a role for interleukin 6 (IL-6) in cancer metastasis (19, 21, 42–44). Tumor-derived soluble factors, including a variety of ECM molecules ...
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Control of Both Myeloid Cell Infiltration and Angiogenesis by CCR1 Promotes Liver Cancer Metastasis Development in Mice
... with tumor development, promoting angiogenesis [26] or metastasis formation [27]. Surprisingly, when irradiated and reconstituted with BM from control mice, CCR1-deficient mice have a longer survival than ...
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Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis.
... in cancer cells [ 61 ]. Chen et al. found that, in cancer cells, the EMT-related gene, ZEB1, acted in concert with the stemness-related gene, Oct4, in increasing PD-L1 expression [ 20 ...
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The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway
... This process of trying to characterize the signaling networks and molecular pathways involved in cellular signaling and the mechanical machinery of the cell allows the [r] ...
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Chemokines: novel targets for breast cancer metastasis.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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TGFBI modulates tumour hypoxia and promotes breast cancer metastasis
... Supplemental File 8: Survival curves of breast cancer patients in the METABRIC cohort who received chemotherapy classified according to the expression of TGFBI. Patients were stratified using the application ...
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DU145 human prostate cancer cells express functional receptor activator of NFkappaB: new insights in the prostate cancer bone metastasis process.
... 8. Corey E, Brown LG, Kiefer JA, Quinn JE, Pitts TE, Blair JM, Vessella RL. Osteoprotegerin in prostate cancer bone metastasis. Cancer Res 2005; 65: 1710-8. 9. Whang PG, Schwarz EM, Gamradt SC, ...
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Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.
... breast cancer cells to metastasize to the ...breast cancer cells metastatic to brain, prevents TEM of MCF-7, MDA- MB-231, and MDA-MB-361 cells across the monolayer of HCMEC/D3 ...breast cancer ...
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Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
... and cancer cell migration/invasion. In cancer, EMT involves complex cell signaling cascades that result in the alteration of cell –cell and cell–extracellular matrix interactions, leading to the acquisition ...
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ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
... Introduction Cancer metastasis results from a multistep process that selects for invasive tumor cells capable of escaping from the primary site and colonizing distant ...breast cancer patients at ...
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Adhesion-GPCRs in cancer progression and metastasis
... diverse cancer types have revealed significant alterations (copy number and mutational) in adhesion-GPCRs, yet no comprehensive examination of their roles in cancer biology ...breast cancer ...
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ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer
... breast cancer where DEK expression is correlated with clinical features of the dis- ease (Wise-Draper et ...breast cancer metastasis in vivo through promotion of β-catenin signaling (Privette ...
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Zebrafish xenograft models of cancer and metastasis for drug discovery
... breast cancer is correlated with poor distant metastasis free survival, leading the authors to conclude that Smad6 and BMP signalling contribute to development of metastatic breast ...breast cancer ...
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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
... breast cancer management [ 30 ...the metastasis-suppressive function of NME1, which is lost upon repression of NME1 expres- sion during cancer ...
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Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis
... 202 ). While SEM and TEM provide highly detailed information on microstructure and nanostructure of collagens, respectively, the preparation steps may greatly alter the samples. SEM can be used to image morphology and ...
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Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
... mammmary stem cells (MaSC) with contour plots shown for LD (black) and JL (red) tumours (SSC: side scatter). b Frequency of CD24 med CD29 hi CD49f hi mammary stem cells (MaSC) in LD and JL tumours ( n = 13). Data are ...
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