bone metastasis
Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
... bone metastasis ...the bone metastatic ...the bone metastasis and B02 cells, suggesting that it could be part of the osteotropic ...of bone, which are cancer cells known to ...
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Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis.
... of bone metastasis-specific genes in 1205Lu cells in vitro and in ...of bone metastasis-specific genes by Smad7 occurred in vivo, RNA was extracted from bone and subcutaneous metastases ...
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Dual function of ERR alpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.
... in bone metastasis formation, CT (pool of CT-1 and -2 clones), WT-1, and AF2 (pool of AF2-1, -2 and -3 clones) cells were inoculated intra- venously into female BALB/c nude ...cancer-induced bone ...
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DU145 human prostate cancer cells express functional receptor activator of NFkappaB: new insights in the prostate cancer bone metastasis process.
... 8. Corey E, Brown LG, Kiefer JA, Quinn JE, Pitts TE, Blair JM, Vessella RL. Osteoprotegerin in prostate cancer bone metastasis. Cancer Res 2005; 65: 1710-8. 9. Whang PG, Schwarz EM, Gamradt SC, Dougall WC, ...
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Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation.
... neoformed bone decreasing the bone content on this ...ideal bone substitute must be resorbable to be replaced by new bone in a fracture site [39] ...in bone loss as observed in post- ...
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The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice
... with bone metastasis is essentially incurable with current anticancer ...The bone morphogenetic protein (BMP) pathway is an attractive therapeutic candidate, as it is involved in the bone ...
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Deterministic Adjustable Bone Plate Design
... 3 Results A closed-form model with a fixed-fixed boundary condition indicates that a force of 292N is needed to deform the present plate adaptation. Numerical modeling results suggest a required force of 375N. Previous ...
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Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis
... multistep process in which each step constitutes a potential angle of attack for a new therapeutic strategy 566 development. Ion channels are implicated in the growth, migration, invasion and metastasis of tumors ...
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Identification of high-quality cancer prognostic markers and metastasis network modules
... several metastasis network modules in which each module contains the genes of one signature and their directly interacting partners that are cancer driver-mutating ...
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Jeu de pistes chez Betty Bone
... Betty Bone n’avait sans doute pas anticipé pareille question ; pourtant, elle y répond graphiquement en 2008 avec Dudu, Coco et Nana : pendant l’escapade de ses trois filles (mais elle ignore que l’une d’entre ...
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Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma
... RESULTS AGRN, SERPINB5 and CSTB are upregulated in PDAC and correlate with poor patient survival We previously used proteomics to identify matrisome proteins overrepresented during PDAC progression and found that high ...
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Phyto-oestrogens and bone health
... targeting bone health the main issue that remains to be resolved is the effect of phyto- oestrogens in terms of bone strength (which is the ultimate hallmark of bone ...
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Bone mass of the calvarium
... 6. Okamoto K, Ito J, Furusawa T, Sakai K, Tokiguchi S, Sato M, Tanaka R, Nemoto K, Oyanagi K. Plasmacytomas of the occipital bone: a report of two cases. Eur Radiol. 1997;7(4):503 –6. 7. Zigouris A, Drosos D, ...
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Bone disease after kidney transplantation
... Bone Disease after Kidney Transplantation Antoine Bouquegneau,* Syrazah Salam, † Pierre Delanaye,* Richard Eastell, ‡ and Arif Khwaja † Abstract Bone and mineral disorders occur frequently in kidney ...
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ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
... Activation of the VEGFR2 tyrosine kinase receptor by VEGF-A, which promotes endothelial cell proliferation, sprouting, migration, as well as vascular permeability, is a major pathway inducing angio- genesis (Lohela et ...
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Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
... AhR has a role in melanoma primary tumorigenesis and lung metastasis. Indeed, we have recently reported that stable AhR knockdown in B16F10 melanoma cells enhanced their tumorigenicity and their metastatic po- ...
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TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment.
... involved, and bones of the pelvis are the next most commonly involved site. Extraosseous Ew- ing’s sarcomas comprise 15% of cases and may arise anywhere else in the body, including skin and visceral organs. Patients with ...
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Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach
... organic bone matrix, and only a small fraction is ...during bone resorption, the OC entrapped in the mineralized matrix is released so that serum concentration also reflects the osteolytic process; hence, OC ...
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Peripubertal female athletes in high-impact sports show improved bone mass acquisition and bone geometry
... the bone response according to the type of ...each bone site in trabecular and cortical bone, as well as in upper and lower ...same bone profile as CON and had lower values than ...induce ...
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Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach
... studying metastasis itself. Metastasis starts with localized primary tumor growth which then invades and intravasates into the bloodstream which, in turn, spreads systemically until extravating into tissue ...
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