Bile duct ligation (BDL)
3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model
... Here, we expand upon these studies and demonstrate that EP-3533 can accurately stage biliary fibrosis in bile duct ligated (BDL) rats. While our initial studies were performed on high field small animal ...
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The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis
... Abstract Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and ...
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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
... GB bile volume in WT and TGR5-KO mice after BDL. Left histogram: GB bile volume analysis (n = 4–25 mice/group); representative photographs at 7 days after ...macroscopic bile infarcts observed on the ...
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Progressive resistance training prevents loss of muscle mass and strength in bile duct‐ligated rats
... The bile duct li‐gated rat: A relevant model to study muscle mass loss in ...of bile duct ligation and carbon tetrachloride ‐induced liver ...
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AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
... The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment ...
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Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.
... Abstract Bile acids have recently been demonstrated as molecules with endocrine activities control- ling several physiological functions such as immunity and glucose ...from bile acids (BAs) and targeting ...
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Magnetic resonance spectroscopy of bile in the detection of cholangiocarcinoma
... of bile samples in distinguishing cholangiocarcinoma from benign biliary ...of bile samples obtained from patients with cholangiocarcinoma and benign biliary ...
4
Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice
... on bile acid ...hydrophobic bile that was paralleled by reduced fecal neutral sterol ...hydrophobic bile acid pool in L-G6pc −/− ...of bile composition upon hepatic ChREBP knockdown reverses ...
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Determinants of postprandial plasma bile acid kinetics in human volunteers
... Taken together, our study describes different BA kinetics following an OGTT and a MMTT and identified key determi- nants underlying the large interindividual variability in post- prandial BA profiles. The different ...
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Turbulent flow and transient convection in a semi-annular duct
... Fig. 13 shows isocontours and radial pro files of the axial velocity at different azimuthal angles q . We choose the value of the angle q equal to 0 for the wall (x axis) and p /2 for the symmetry plane (y axis). The ...
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Duct smoke detectors : the impact of various factors on their effectiveness
... for duct smoke detectors include an evaluation of the sampling system at five velocities in the range of ...of duct smoke detectors as a function of system air velocities of ...
5
Robust optimization of a 2D air conditioning duct using kriging
... However, real life problems are almost always non-deterministic. Uncertainties appear for example due to model errors, manufacturing tolerances, changing environments and noisy measurements. A kriging based method ...
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Optimal disturbance in a flow duct with a lined wall
... x L Fig. 1. Geometry of the lined flow duct. The three bullet points represent pressure sensors. 1.1. Governing equations and problem formulation The configuration studied in this paper is a two-dimensional ...
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Running head: Heat affects cholesterol and bile acid alterations in cholesterol and bile acids metabolism in large white pigs during short-term heat exposure
... Bile acids are synthesized from cholesterol in the liver and play an essential role in cholesterol homeostasis. In the current study, heat exposure of pigs led to a substantial increase in the hepatic ...
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Developments in Canada on portable air cleaners, duct cleaning and heat recovery
... Overthe next three years, NRC’s team is engaging in research and furtherprotocol development targeted towards the removal ofVOCs by passive panels, as well as particle removal and by-product emissions by in-duct ...
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Synthesis and characterization of main-chain bile acid-based degradable polymers
... Three different methods can be used to prepare bile-acid-based polyanhydrides. The first developed in our group involved a selective hydrolysis of 3 α-lithocholic acid methyl ester dimers, previously synthesized ...
130
Polyamides and polyesters made of bile acids in the main chain
... Bile acids also possess several chiral centers. The modification of hydroxyl and carboxylic groups of bile acids can give rise to a diverse range of bile acid-based compounds. The carboxylic acid ...
102
Is ventilation duct cleaning useful? A review of the scientific evidence
... There is no field study evidence to show that dust accumulation can cause higher energy consumption, poor HVAC system performance or decreased air flow rates. With increasing humidity, dust deposition can be enhanced ...
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Parallel Budgeted Optimization Applied to the Design of an Air Duct
... osts of updating λ > 1 points will typi
ally be greater than in the single point ase, unless every one out of λ omputational nodes is faster than the one applied in the optimization[r] ...
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Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation
... 4. CONCLUSIONS In conclusion, we report sortase-mediated ligation of human EGF to preformed PEG hydrogels. This enzymatic approach is not only simple and relatively inexpensive, but it also displays high speci ...
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