Bile acid
Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.
... Previous studies have shown that detectable levels of BAs are present in testis even in normal physiological condition 5,13 . It is thus interesting to question whether 1/these BAs come from plasma only or could be ...
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Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.
... BAs alter seminiferous epithelium integrity We have recently identified that BA impact testicular physiology through TGR5 dependent mechanisms [ 5 ]. TGR5 activation leads to the control of the TBX2-Cx43 pathways which ...
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The effect of exercise training on cholesterol and bile acid metabolism in ovariectomized rats
... v experimental group was Ovx rats fed a high cholesterol diet (Ovx-Chol) that was compared, on one hand, to a group of Ovx rats fed a standard diet (Ovx-SD) to observe the effects of the diet and, on the other hand, ...
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Running head: Heat affects cholesterol and bile acid alterations in cholesterol and bile acids metabolism in large white pigs during short-term heat exposure
... and bile acid (BA) metabolism are affected by heat ...and bile acids when pigs are exposed to short term heat stress, 24 Large White pigs ...taurolithocholic acid, taurochenodeoxycholic ...
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Synthesis and characterization of main-chain bile acid-based degradable polymers
... prepare bile-acid-based ...α-lithocholic acid methyl ester dimers, previously synthesized by linking two lithocholate methyl ester molecules with sebacoyl chloride, yielded carboxylic acid ...
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Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice
... hepatic bile acid synthesis, C57BL/6 mice were infused during 6 hours with S4048, a selective inhibitor of the G6P transporter, SLC37A4, thereby acutely inducing GSD Ib in ...in bile acid ...
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Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
... micelles. Bile acid-based block copolymers present certain advantages over traditional polymer-based systems for drug delivery purposes, since they can enable a higher drug loading via the formation of a ...
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Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice
... BA, bile acid; BTB, blood-testicular barrier; CA, cholic acid; cDNA, complementary DNA; Cx43, connexin-43; Cyp3a11, cytochrome P450, family 3, subfamily a, polypeptide 11; DCA, deoxycholic ...
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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
... and bile from WT and TGR5-KO mice 6 h after EH (n = 6 –8 ...BA, bile acid; CT, cholestyramine; DCA, deo xycholic acid; EH, extended hepatectomy; KO, knockout; MCA, muricholic acid; ND, ...
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Determinants of postprandial plasma bile acid kinetics in human volunteers
... Determinants of postprandial plasma bile acid kinetics in human volunteers. Am J Physiol Gastrointest Liver Physiol 313: G300 – G312, 2017. First published June 29, 2017; doi:10.1152/ ...
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Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems
... condition the fate of lipid-based formulations (LBF) and the dispersion, solubilisation and absorption of lipophilic drugs in the GI tract. Since in vitro methods of digestion are now combined with dissolution assays for ...
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The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate
... To determine how FXRa deficiency led to an increase in the number and maintenance of UGCs, in addition to Oct3/4, Nanog, and Thy1 we also focused on the altered expression of several gen[r] ...
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en fr Identification of bile acid nuclear receptor FXR alpha as a proviral factor for hepatitis B virus Identification du récepteur nucléaire des acides biliaires FXR alpha comme facteur proviral pour le virus de l’hépatite B
... Identification du récepteur nucléaire des acides biliaires FXR alpha comme facteur proviral pour le virus de l’hépatite B Karim Mouzannar.. To cite this version: Karim Mouzannar.[r] ...
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A bile acid transporter as a candidate receptor for hepatitis B and D virus entry.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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A dynamic mathematical model of bile acid clearance in HepaRG cells
... HepaRG cells were treated with different concentrations of CsA (0, 1, 5, 10, 25 and 50 µM) or CPZ (0, 20 and 50 µM) for 30 min. After washing, cells were loaded with [ 3 H]-TCA-containing buffer at different time points ...
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Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways
... solubilization, bile acids (BAs) have been described as signaling molecules activating the nuclear receptor Farnesoid-X-receptor (FXRα) or the G-protein- coupled bile acid receptor-1 (GPBAR-1 or ...
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Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics
... Cholestasis is an early and frequent complication in patients with sepsis that is characterized by a systemic inappropriate inflammatory response to bacterial infection resulting in the release of lipopolysaccharide ...
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Polyamides and polyesters made of bile acids in the main chain
... Heterofunctional bile acid-based monomers were synthesized and used in order to overcome stoichiometric imbalances during step-growth ...lithocholic acid derivative bearing amine and protected ...
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In vivo evidence for transintestinal cholesterol efflux in patients with complete common bile duct obstruction
... any bile acid species in the feces (data not ...blood, bile and feces samples prior an intravenous injection of D7-cholesterol (100mg) and 10 minutes, 24h, 48h and 72h after the ...the bile ...
13
Supramolecular hydrogels based on bile acids and their derivatives
... applications. Bile acids have attracted increasing attention for designing various biomaterials, including molecular ...on bile acids, including bile salts, anionic, cationic and neutral bile ...
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