Autophagy-related
The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages
... an autophagy inhibitor, Bafilomycin A1, we were able to restore the WT Mtb growth phenotype [ 31 ], indicating that autophagy could contribute to growth ...an autophagy-related pathway that ...
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Amino acids downregulate the expression of several autophagy-related genes in rainbow trout myoblasts
... Amino acids downregulate the expression of several autophagy-related genes in rainbow trout myoblasts... 2 INRA, UR1037 Station Commune de Recherches en Ichtyophysiologie, Biodiversité [r] ...
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Increased autophagy-related 5 gene expression is associated with collagen expression in the airways of refractory asthmatics
... During autophagy, autophagy-related 5 (ATG5) is covalently conjugated with ATG12 and interacts with ATG16 to form the ATG12–ATG5–ATG16 complex ( 15 ...between autophagy and other forms of cell ...
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BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.
... Supplemental Materials and Methods Autophagy measurement Staining of endogenous LC3: 12 µm-thick liver and lung sections of paraffin-embedded WT and Bat3 -/- E18.5 mouse embryos were deparaffinized, and subjected ...
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Autophagy signaling and the cogwheels of cancer.
... in autophagy, 12,43 because this complex is generally considered to be stimulatory and required for ...studies, autophagy was not investigated directly. It is possible that an ...
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Autophagy drives fibroblast senescence through MTORC2 regulation
... of autophagy [44]. For example, they are essentials for ATG4A (autophagy related 4A cysteine peptidase) activation and phagophore elongation ...between autophagy, ROS production, and MTORC2 ...
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An assembly model for the autophagy initiation complex
... the autophagy initiation complex (AIC), is the first autophagy-related protein complex that assembles upon starvation and it is composed of five proteins: Atg1, Atg13, Atg17, Atg29 and Atg31 (Chew LH ...
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[Autophagy and CD4 T lymphocyte destruction by HIV-1]
... dant des gènes ATG (autophagy-related genes), faisant intervenir deux systèmes de conjugaison semblables au processus d’ubiquitination (formation des conju- gués Atg12-Atg5-Atg16 et Atg8/LC3-PE), et de ...
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Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044
... induces autophagy- dependent apoptosis, which is directed by an accelerated degradation of the antiapoptosis protein Survivin, via its acetylation- dependent interaction with the autophagy- related ...
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Mechanical Ventilation-induced Diaphragm Disuse in Humans Triggers Autophagy
... of autophagy-related genes that are involved in the initiation, elongation, and maturation of the autophagosomes (Figure ...that autophagy is substantially induced in limb muscles on selective ...
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Protein complexes and neighborhoods driving autophagy
... on autophagy-related pro- teins and proteins involved in autophagosome biogenesis utilized the expression of 65 HA-tagged bait proteins, of which 32 were primary and 33 secondary baits, in HEK293T ...to ...
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Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
... of autophagy-related genes (ATGs) in Saccharomyces cerevisiae (reviewed in Bento et ...of autophagy is tightly coupled to cell growth regulation via either inhibition or stimula- tion of ...
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AMPK promotes tolerance to Ras pathway inhibition by activating autophagy
... tolerance, autophagy Abbreviations: BRAF, v-Raf murine sarcoma viral oncogene homolog B; RAS, rat sarcoma viral oncogene; AMPK, AMP-activated protein kinase; AICAR, 5- Aminoimidazole-4-carboxamide ribonucleotide; ...
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Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
... if autophagy inhibition will be potentially effective to diminish tumorigenesis is establishing if tumors are more susceptible to acute autophagy inactivation than normal tissues, therefore providing a ...
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Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
... Autophagy involves an intracellular homeostatic process wherein newly formed double-membrane vesicles termed autophagosomes, engulf long-lived proteins or organelles such as mitochondria, and transfer them to ...
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The role of host autophagy machinery in controlling Toxoplasma infection
... ]. AuTophaGy-related (ATG) proteins coordinate this process, which is initiated by the for- mation of a double-membrane cytosol-sequestering vesicle, termed the phagophore that can engulf either random ...
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required
... 6. Gorgulu K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, et al. Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology ...
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Macrophage Autophagy and Bacterial Infections
... Keywords: autophagy, macrophage, bacteria, pathogen, phagocytosis, xenophagy, inflammation inTRODUCTiOn Macroautophagy, hereafter referred to as autophagy, is a lysosomal degradative process that partici- ...
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Identification of autophagy genes in Ciona intestinalis : A new experimental model to study autophagy mechanism
... 1 Autophagy (Type II PCD) is a bulk degradation process whereby organelles and cytoplasm are engulfed in a double membrane network that is targeted to ...if autophagy was first studied for its role in cell ...
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Autophagy and Nutrients Management in Plants
... In small-grained cereals like wheat and rice, up to 90% of the grain nitrogen content is remobilized from the vegetative plant parts, while the proportion in maize is approximately 35–55% [61]. Once senescence is ...
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