Aryl hydrocarbon receptor (AhR)
The Prognostic Impact of the Aryl Hydrocarbon Receptor (AhR) in Primary Breast Cancer Depends on the Lymph Node Status
... ‡ These authors contributed equally as senior authors. Received: 18 January 2019; Accepted: 20 February 2019; Published: 26 February 2019 Abstract: Increasing evidence implicates the aryl ...
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Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta
... The aryl hydrocarbon receptor (AhR) is one of the most important environmental-sensor transcription factors and mediates the metabolism of a wide variety of ...
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Aryl Hydrocarbon Receptor Activation and Tissue Factor Induction by Fluid Shear Stress and Indoxyl Sulfate in Endothelial Cells
... * Correspondence: laetitia.dou@univ-amu.fr; Tel.: +33-4-91835683 † These authors contributed equally to this work. Received: 2 March 2020; Accepted: 29 March 2020; Published: 31 March 2020 Abstract: ...
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Aryl hydrocarbon receptor and liver fibrosis
... 1. Introduction Liver fibrosis is defined as a response to a sustained cell injury and chronic inflammation that leads to the activation of pro-fibrotic cells and the excessive deposition of extracellular matrix. While ...
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Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes
... Abstract Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a pulmonary toxin that ...
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The Aryl Hydrocarbon Receptor, More than a Xenobiotic-Interacting Protein
... This receptor belongs to the basic-helix-loop-helix (bHLH)/PAS (Period [Per]-Aryl hydrocarbon receptor nuclear translocator [Arnt]-Single minded [Sim]) family of heterodimeric transcriptional ...
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Aryl Hydrocarbon Receptor-Dependent Induction of Liver Fibrosis by Dioxin
... Butler, R., Inzunza, J., Suzuki, H., Fujii-Kuriyama, Y., Warner, M., and Gustafsson, J. A. (2012). Uric acid 21 stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Proc ...
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The Aryl Hydrocarbon Receptor and the Nervous System
... * Correspondence: xavier.coumoul@parisdescartes.fr; Tel: +33-14-286-3359; Fax: +33-14-286-3868 Received: 27 July 2018; Accepted: 21 August 2018; Published: 24 August 2018 Abstract: The aryl ...
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Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France
... the aryl hydrocarbon receptor (AHR) discussed here provide a perfect example of how years of basic toxicological research on a molecule, whose normal physiological function remained a mystery for so ...
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The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease
... When a ligand binds to AhR, the AhR/ligand/Hsp90 complex translocates into the nucleus and dimerizes with ARNT (Aryl hydrocarbon receptor nuclear translocator). The AhR/ARNT complex recognizes a DNA ...
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The Role of Aryl Hydrocarbon Receptor (AHR) and AHR-Interacting Protein (AIP) in the Pathogenesis of Pituitary Adenomas
... (Aryl hydrocarbon Receptor, or dioxin receptor) is stabilized by AIP in a cytoplasmic AhR/AIP/hsp90/p23 core complex; upon activation by exogenous AhR moves to the nucleus, heterodimerizes ...
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Oculomotor Deficits in Aryl Hydrocarbon Receptor Null Mouse
... The Aryl hydrocarbon Receptor or AhR, a ligand-activated transcription factor, is known to mediate the toxic and carcinogenic effects of various environmental pollutants such as ...
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STUDY OF THE 16 EU-JECFA PAHs INTERACTION WITH THE ARYL HYDROCARBON RECEPTOR (AhR) USING RAT AND HUMAN REPORTER CELL LINES
... cellular aryl hydrocarbon receptor (AhR) activation which can be evaluated with the in vitro CALUX bioassay (Chemically Activated LUciferase gene ...
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Aggressive prolactinoma in a child related to germline mutation in the ARYL hydrocarbon receptor interacting protein (AIP) gene.
... the aryl hydrocarbon receptor interacting protein (AIP) gene, were reported to be involved in the predisposition to pituitary adenoma formation ...
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Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor
... the aryl hydrocarbon receptor and its new molecular and cellular ...the receptor, and showed that its induction was critical for cell plasticity mediated by environmental ...
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Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.
... [23] Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology. 2000;141:3657-67. [24] Revel A, Raanani H, Younglai E, Xu J, ...
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The R304X mutation of the Aryl hydrocarbon receptor Interacting Protein gene in familial isolated pituitary adenomas: mutational Hot-Spot or founder effect?
... The R304X mutation of the aryl hydrocarbon receptor interacting protein gene in familial isolated pituitary adenomas: Mutational hot-spot or founder effect?. Scaroni1 1Endocrinology Divi[r] ...
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A realistic mixture of Persistent Organic Pollutants (POPs) reveals possible synergism to inhibit the transactivation activities of the rat Aryl hydrocarbon Receptor (rAhR) in vitro
... Exposure to mixtures of Persistent Organic Pollutants (POPs) can inhibit the transactivation activities of the rat Aryl hydrocarbon Receptor (rAhR) in vitro Doan TQ. 1 , Muller M. 2 , Berntsen HF. 3 ...
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Variable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein gene
... Environmental factors are another important area of great relevance to discussions of AIP and its potential role in endocrine pathology. Current understanding of the role played by AIP in pituitary cell function is still ...
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Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites
... dramatically affected their ability to trans-activate the AhR signaling pathway, might be related to the structural plasticity of the receptor. Indeed, we previously showed that different AhR ligands activated ...
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