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ARE-mediated mRNA decay

Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay

Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay

... cases are caused by dominantly‑inherited mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), which represents one of the most frequent genetic cause of ...identified. mRNA harboring PTCs ...

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Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes

Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes

... mRNAs are clustered either above (eRF3A knockdown) or below (UPF1 knockdown) the control cell level (log2 Fold Change = 0 in ...RPL41 mRNA and suggested that its very short ORF, encoding only 25 amino ...

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The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)

The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)

... “aberrant” mRNA, NMD can also periodically regulate specific “non-aberrant” ...an mRNA sequence, organization and/or mRNP ...CREB-2/ATF4 mRNA is a well-documented example ...of mRNA that ...

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Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

... to mRNA/asXUT is supported by CRAC data, and the insensitivity of XUTs to Trf4 and Trf5 suggests that Mtr4 act on XUTs independently of the TRAMP4/5 ...that mRNA/ asXUT duplexes exist in the nucleus where ...

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Mechanistic insights of SIDER2 retroposon-mediated mRNA decay in Leishmania

Mechanistic insights of SIDER2 retroposon-mediated mRNA decay in Leishmania

... starvation are the best studied SGs in ...polyadenylated mRNA that was quite stable even after extended inhibition of transcription, suggests that these granules might be the sites of storage and stability ...

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Composition et dynamique des complexes protéiques impliqués dans le "nonsense-mediated mRNA decay" chez la levure Saccharomyces cerevisiae

Composition et dynamique des complexes protéiques impliqués dans le "nonsense-mediated mRNA decay" chez la levure Saccharomyces cerevisiae

... Ebs1 are accessory factors for NMD in yeast and could be functional homologues of human Smg6 and Smg5/7 respectively ...results are compatible with a large body of experimental evidence in various other ...

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The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1

The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1

... the mRNA decay machinery (Lykke-Andersen and Wagner, 2005; Sandler et ...sites are in- deed phosphorylated by PKA in ...they are PKA target ...TIS11b-dependent mRNA decay has not ...

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Early stages of leaf decomposition are mediated by aquatic fungi in the hyporheic zone of woodland streams

Early stages of leaf decomposition are mediated by aquatic fungi in the hyporheic zone of woodland streams

... Shredders are known to act both as competitors and predators of fungi, because of their preferential feeding on leaf patches colonised by fungi, thus reducing microbial activity (Ba¨rlocher, 1980; Suberkropp, ...

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Decay of wood

Decay of wood

... that are of importance. These are Lenzites saepiaria, Lenzites trabea, Fomes roseus, Lentinus lepideus, and Merulius ...five are perhaps the most ...

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Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.

Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.

... neutrophils are recruited in the pancreatic islets of neonatal NOD mice? The infiltration of immune cells in the pancreatic islets during the T1D development has been extensively investigated revealing a role for ...

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An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes

An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes

... RESULTS Profiling the RNA Structure of 5 0 UTRs in Listeria monocytogenes We adapted a DMS-MaPseq protocol ( Zubradt et al., 2017 ) to focus on the dynamics of 5 0 UTR structures in the bacterial path- ogen L. ...

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Cyclophilins and nucleoporins are required for infection mediated by capsids from circulating HIV-2 primary isolates

Cyclophilins and nucleoporins are required for infection mediated by capsids from circulating HIV-2 primary isolates

... It has been reported that HIV-2 does not require host CypA for efficient replication in human cells 54 . Even if a weak binding between HIV-2 CA and CypA has been detected in a previous report 56 , the interac- tion of ...

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Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

... ure 2A). Importantly, D 2L (red) was well co-localized with FABP3 (green) in TH + neurons (blue) in WT, whereas no D 2L signal was observed in D 2L−/− TH + neurons (Figure 2B). Figure 1. The primary sequence of mouse ...

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The first digestive movements in the embryo are mediated by mechanosensitive smooth muscle calcium waves

The first digestive movements in the embryo are mediated by mechanosensitive smooth muscle calcium waves

... 4°) Calcium waves can be elicited in smooth muscle cell cultures by gentle mechanical stimulation (19,27). Bayliss & Starling (28) discovered more than a century ago that peristalsis movements in the adult (dog) ...

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Outer Plexiform Layer Structures Are Not Altered Following AAV-Mediated Gene Transfer in Healthy Rat Retina

Outer Plexiform Layer Structures Are Not Altered Following AAV-Mediated Gene Transfer in Healthy Rat Retina

... detachments are known to cause remodeling of retinal neuronal structures as well as significant cell loss, the possible effects of this short-term therapeutic retinal detachment on retinal structure and circuitry ...

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The Melanoma Antigens MELOE-1 and MELOE-2 Are Translated from a Bona Fide Polycistronic mRNA Containing Functional IRES Sequences

The Melanoma Antigens MELOE-1 and MELOE-2 Are Translated from a Bona Fide Polycistronic mRNA Containing Functional IRES Sequences

... meloe mRNA that contained only multiple short ...same mRNA could be translated into a second antigen, coined MELOE-2, that also triggered T cell responses in melanoma patients ...polycistronic mRNA ...

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On decay constants and orbital distance to the Sun. Part I: alpha decay

On decay constants and orbital distance to the Sun. Part I: alpha decay

... α decay. Part II [ 58] groups the evidence for beta minus decay and in part III [59] β + and EC decay are investi- ...Graphs are shown of residuals of integrated count rates or ...

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Cytoplasmic Control of Sense-Antisense mRNA Pairs

Cytoplasmic Control of Sense-Antisense mRNA Pairs

... SUMMARY Transcriptome analyses have revealed that conver- gent gene transcription can produce many 3 0 -over- lapping mRNAs in diverse organisms. Few studies have examined the fate of 3 0 -complementary mRNAs in ...

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On decay constants and orbital distance to the Sun—part I: alpha decay

On decay constants and orbital distance to the Sun—part I: alpha decay

... α decay. Part II [ 58 ] groups the evidence for beta minus decay and in part III [ 59 ] β + and EC decay are investi- ...Graphs are shown of residuals of integrated count rates or ...

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The Decay Data Evaluation Project (DDEP) and the JEFF-3.3 radioactive decay data library: Combining international collaborative efforts on evaluated decay data

The Decay Data Evaluation Project (DDEP) and the JEFF-3.3 radioactive decay data library: Combining international collaborative efforts on evaluated decay data

... recommended decay data to non-specialists. Typical users are not nuclear structure experts, they are generally metrologists working in the field of alpha- and gamma-spectrometry, or with liquid ...

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