antigen presenting cells (APCs)
en fr Development of cellular immunotherapeutic strategies based on the activation of human CD4+ TL by artificial antigen presenting cells Développement de stratégies d'immunothérapies cellulaires basées sur l'activation de lymphocytes T CD4+ humains à l'aide de cellules présentatrices d'antigène artificielles.
... artificial antigen presenting cells (AAPCs) that derived from a mouse fibroblast cell line genetically modified to express a single human leukocyte antigen class II molecule (HLA-DR), the ...
238
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
... living cells shows great promise for the treatment of a wide variety of complex ...myeloid antigen-presenting cells (APC) with immunoregulatory function to treat autoimmune diseases, or to ...
15
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
... of antigen-presenting cells Noëlla Lopes 1 , Jonathan Charaix 1 , Oriane Cédile 2 , Arnauld Sergé 3 & Magali Irla 1 Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of ...
17
Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells.
... that antigen presenting cells (APC), such as monocytes and dendritic cells (DC), contribute to the modulation of foetal immune responses upon exposure to ...of cells; myeloid DC (MDC) ...
13
Letters to the Editor: Correspondence re R. Lapointe et al., CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells. Cancer Res 2003;63:2836–43.
... CD40-B cells generate tumor antigen-specific CD4 ⫹ T cells in cancer patients when the B cells are pulsed with lysate from tumor cells ...CD40-B cells as ...
3
CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells
... as antigen-presenting cells, the role of antigen-unspecific B lymphocytes in antigen presentation and T-lympho- cyte stimulation remains ...B cells to stimulate T cells ...
8
Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
... Ito Cells Express CD1 Molecules and APC Surface Markers In order to investigate the impact of Ito cells on NKT cells, we isolated Ito cells from liver of C57BL/6 mice via the pro- nase and ...
14
Mechanism of action and recruitment of antigen-presenting cells in a mouse model of multiple sclerosis
... for antigen-presentation, CD80, CD86, maturation, CD83, and pro- inflammatory cytokines such as, IL-6, IL-12, with CCR7 for migration of DCs to the T cell zone of secondary lymphoid ...T cells in the lymph ...
155
en fr Study of HIV-1 transfer from antigen presenting cells to primary CD4 T lymphocytes and inhibition by neutralizing antibodies Etude du transfert du VIH-1 des cellules présentatrices d'antigènes aux lymphocytes T CD4 primaires et inhibition par les anticorps neutralisants
... Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.. Gan[r] ...
178
Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization
... from cells fixed 30 minutes after engagement with behavior at early times, we followed the spreading dynamics of ZAP-70-GFP and Mem-GFP (a membrane- labeled cell-line) cells while they interacted with ...
30
Anti-Gal-mediated targeting of human B lymphoma cells to antigen-presenting cells: a potential method for immunotherapy using autologous tumor cells.
... tumor cells can be processed in this reaction in an enzyme reaction vol- ume of no more than 30 ...phoma cells to APC and the various experimental ani- mal models indicating that such opsonized vaccines are ...
11
Mechanics of antigen extraction by B cells
... B cells produce antibodies and are therefore essential effectors of adaptive ...neighboring antigen presenting ...B cells to extract and process ...B cells: (1) Membrane spreading ...
146
Antigen-Bearing Dendritic Cells Regulate the Diverse Pattern of Memory CD8 T Cell Development in Different Tissues
... T cells into different memory T-cell ...this antigen are a significant factor, we used naïve 2C cells as reporters to monitor the antigen- bearing DCs at different times and in different ...
7
Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus
... B cells with a BCR specific for the HA of A/WSN/33 (FluBI ...B cells secrete an IgG2b that neutralizes infectious virus. While B cells from FluBI and control mice bind equivalent amounts of virus ...
14
CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate
... Immunohistochemistry At indicated time points after T cell treatment, the genitourinary tract was excised and all four prostate lobes dissected and flash frozen in OCT compound (Tissue-Tek, Sakura). All tissues were ...
17
Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells
... in FACS buffer followed by surface staining. Anti-CD25 allophycocyanin (APC) was purchased from eBioscience (San Diego, CA). Anti-CD45 PE/CF594 was purchased from BD Biosciences (San Jose, CA). Anti-PD-1 fluorescein iso- ...
18
ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells.
... stem cells express transmem- brane transporters, including ...the cells and as such, behaves as one of the major mediators of side population ...stem cells from different organs and species ...SP ...
14
Anthrax Protective Antigen Retargeted with Single‐Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells
... mPA-scFv fusions efficiently translocate a toxin-derived reporter to the cellular cytosol. The enzyme DTA (catalytic A chain of diphtheria toxin) inhibits protein synthesis via ADP-ribosylation of eukaryotic elongation ...
7
A high-throughput method for characterizing novel chimeric antigen receptors in Jurkat cells
... and cells expressing EGFRvIII as antibodies ( Fig- ure S2 ...Jurkat cells were electropo- rated, seeded in 96-well plates, and co-cultured with varying numbers of U87 or EGFRvIII-expressing U87-vIII ...
18
Writing and presenting a useful Course Syllabus
... with basic desires to know (“to be aware of reality, to get the facts, to satisfy curiosity, to see rather than to be blind”) and to understand (“to systematize, to organize, to analyz[r] ...
40