and NK-T cells
Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells
... 1 and four group 2 donors are ...the NK cell responses of group 1 and 2 donors to EBV, and no significant expansion of other invariant T cells, such as V δ1 T cells, ...
17
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells
... Immunology and Biochemical Genetics, PathWest, Royal Perth Hospital, Western Australia Genetic polymorphism of KIR2DL4 results in alleles with either 9 or 10 consecutive adenines in exon 6, which encodes the ...
13
Kinetics of Cytotoxic Lymphocytes Reconstitution after Induction Chemotherapy in Elderly AML Patients Reveals Progressive Recovery of Normal Phenotypic and Functional Features in NK Cells
... NK cells belong to the innate immune system and secrete many cytokines, such as GM-CSF, IL-10, or pro-inflammatory cytokines (IFN-γ and TNF-α), and ...of NK cells usually ...
13
Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance
... (NK) cells is becoming a credible immunotherapy for hematological ...human NK cells, we generate expanded NK cells (eNK) with increased expression of CD56 and NKp44, while ...
15
NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
... Patients and methods Patients All participants gave written informed consent in accordance with the Declaration of ...IPC and the ...on NK cells at diagnosis was assessed by flow cytometry in ...
11
NK cells in the tumor microenvironment: Prognostic and theranostic impact. Recent advances and trends
... that NK cells were unique in tumor lesions compared to normal lung from the same patients, and that these changes occur in very early stages tumors ...infiltrating NK cells [53], ...
40
IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells
... MD, and approved May 7, 2014 (received for review March 25, 2014) Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK ...
7
Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases
... T cells are defined by their capacity to respond to signals other than the well-known complex of peptides and major histocompatibility complex ...T cells, innate-like CD8( +) T cells in the ...
17
Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients
... expanded NK cells (eNKs) from two sources combined with the mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) cells ex ...of NK cells, we expanded ...
13
Dissecting the NK cell population in hematological cancers confirms the presence of tumor cells and their impact on NK population function
... system and protects against pathogens and tumor cells. NK cells are the main cell effectors of the monoclonal antibodies (mAbs) that mediates antibody-dependent cell cytotoxicity ...
21
NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27
... EA and MMECs, IL-27 (either alone or in combination with IL-15 1ng ) did not upregulate the expression of PD-L1 or induce that of ...(HUVEC cells) ...type and cytokine ...CD4+ and CD8+ T ...
16
Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.: NK cells in chronic hepatitis C and hepatitis B
... in NK cell frequency and a quantitative imbalance between CD56 bright and CD56 dim subsets were observed in chronic HCV patients as compared to HBV patients, underlining that the inflammatory ...
13
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.
... T cells present in the interfollicular T cell zone, total frozen sections of reactive lymph nodes were stained with CD277 mAbs ...area and mantle B-cell ...
46
Implication des cellules NK au cours des maladies auto-immunes
... sensors and signalling ...TLR8 and TLR9 recognize RNA and DNA ligands, and signal through a key adaptor MyD88 (myeloid differentiation primary-response gene 88) in the ...4) and IRAK1, ...
177
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
... myeloid and NKT cells [11–16], which negatively regulates antigen receptor signaling as part of the normal autoregulatory ...presenting cells (APCs), whereas PD-L1 (B7-H1) is expressed in many ...
18
Défauts fonctionnels des cellules NK en contexte de stimulation chronique
... Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice.. Cancer-expanded myeloidderive[r] ...
329
P04-36. HIV-1-speficic antibody dependant cellular cytotoxicity (ADCC) médiated by primary NK cells
... (NK) cells play an important role in antivi- ral immune responses; they kill HIV-1-infected cells either by direct lysis or through an antibody-dependent cellular cytotoxicity (ADCC) ...activated ...
2
Positioning NK-kappaB in multiple myeloma.
... of NK- B pathway deregulation is MM disease is a consequence of its pivotal role in the process of generation of normal plasma ...T cells and of Toll like receptor by bacterial products induce ...
6
The Modulation of the Cell-Cycle: A Sentinel to Alert the NK Cells of Dangers
... the NK lysis susceptibility ( 9 , 37 ...of NK cells and have influenced the evolution of NK cell receptors and their ligands ( 38 ...phosphorylated and activated by the ...
7
Conditional ablation of NKp46+ cells using a novel Ncr1greenCre mouse strain: NK cells are essential for protection against pulmonary B16 metastases
... with NK cells some phenotypic features (NKp46 and ...of NK cell markers like Ly49 molecules and DX5) ...subsets and whether or not other ILC1 subsets exist. Tissue-‐resident ...
36