amyloid beta precursor protein
Peroxisome Proliferator-Activated Receptor gamma induces a clearance mechanism for the amyloid-beta peptide.
... extracellular amyloid- (A) plaques and the for- mation of intracellular tangles in the ...peptides, protein fragments derived by proteo- lytic cleavage of the amyloid precursor ...
10
Effect of non-steroidal anti-inflammatory drugs on amyloid-beta formation and macrophage activation after platelet phagocytosis.
... of amyloid-  (A), which until then had only been studied in Alzheimer’s dis- ease, in macrophages around microvessels in advanced human atherosclerotic ...contain amyloid precursor protein ...
9
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
... APP, Amyloid Precursor Protein; ATP, Adenosine TriPhosphate; Aβ, Amyloid beta peptide; AβDP, Aβ-Degrading Proteases; CNS, Central Nervous System; CSF, CerebroSpinal Fluid; CTF, ...
16
Calcium- and tyrosine phosphorylation-dependent mechanisms of amyloid precursor protein processing
... Calcium influx induced with ionomycin mimicked the effects of muscarinic receptor activation with carbachol on tyrosine phosphorylation and on APPs secretion.. These ef[r] ...
41
Hydration water dynamics of the tau protein in its native and amyloid states
... of amyloid aggregates with that of monomers, it appears unchanged for tau and for VQIVYK, whereas it is higher for lysozyme and concanavalin ...of protein aggregate dynamics on the ns time scale, which is ...
226
The Bacillus licheniformis BlaP beta-lactamase as a model protein scaffold to study the insertion of protein fragments.
... chimeric protein for different b-lactam substrates were also evaluated in the presence of a reducing agent (dithiothreitol, ...BlaP protein is devoid of cysteine and therefore should not be affected by the ...
12
Disulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein.
... One example is intramolecular disulfide bonds, which limit the ways in which a polypeptide can be arranged in a fibril through the topological restraints that they impose. Although disulfide bonds are present in 15 % of ...
5
Aggregation states of Aβ1-40, Aβ1-42 and Aβp3-42 amyloid beta peptides: a SANS study
... of Amyloid β1-40: Unfolded monomers in DMSO, multidimensional aggregates in water ...of amyloid-β oligomers is decreased in the cerebrospinal fluid of Alzheimer’s disease ...
10
Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS
... In vitro Immunocharacterization PSA-NCAM immuno-selected cells of each genotype were plated on poly-ornithine in EGF/FGF supplemented medium to assay purification efficacy. After short-term adhesion (12 h), cells were ...
15
An Amyloid Organelle: Solid State NMR Evidence for Cross-Beta Assembly of Gas Vesicles
... 2 The abbreviations used are: GVpA, Gas vesicle protein A; MAS, magic-angle spinning; CsgA, curli subunit protein A; PAR, proton-assisted recoupling; DARR, dipolar-assisted rotational resonance. FIGURE ...
14
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
... plasma protein adsorption on platelet plasma membranes, acid- washed platelets were compared with platelets washed in Tyrode ’s buffer at physiological pH, with no significant drop in proBDNF signal in acid-washed ...
12
Effects of monopropanediamino-beta-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD.
... In a previous work, we reported that thermal denaturation of BlaPChBD was accompanied by the formation of an intermediate state (I) which exhibits ANS-accessible hydrophobic clusters. In the present study, we show that ...
8
Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease
... Results We show that overexpression of APP695, or APPswe trig- gers increased Ryanodine receptors (RyR) expression and enhances RyR-mediated ER Ca2+ release in SH-SY5Y neu- roblastoma cells and in APPswe-expressing ...
3
Despite its role in assembly, methionine 35 is not necessary for amyloid β-protein toxicity
... the amyloid β-protein precursor-encoding gene, which leads to substitution of Met 35 in Aβ by ...as protein carbonylation and lipid peroxidation in the brains of the mice, yet the substitution ...
22
Whey protein isolate modulates beta-carotene bioaccessibility depending on gastro-intestinal digestion conditions
... smaller protein fragments, ...secondly, protein addition, via their emulsifying properties, reduced lipid droplet size after digestion, and also resulted in lower mixed micelle size, which may have ...
39
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-beta Peptides
... A β peptide recombinant production was attempted in yeast [ 11 ] or by combining recombi- nant and synthetic procedures [ 12 ] but, to date, the most common expression system remains Escherichia coli. Most often, ...
14
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro
... compared protein abundance between mice and naked mole-rats (Figure ...normalized protein abundances are provided for each brain region in the supplemental information (Supplementary Figure ...
26
Aggregation studies of the beta (34-42) peptide and synthesis of targets for amyloid staining and imaging
... Either the two peptides follow totally independent aggregation processes in which the native and depsipeptides each form their own, homogeneous, fibrils, or the incorporation[r] ...
48
Cross-sectional associations of plasma vitamin D with cerebral beta-amyloid in older adults at risk of dementia
... Background: Vitamin D deficiency is associated with an increased risk of Alzheimer ’s disease and increased beta-amyloid (A β) in animals. Hence we sought to investigate the relationship between plasma ...
8
Molecular interactions between monoclonal oligomer-specific antibody 5E3 and its amyloid beta cognates
... protein. With the latter fusion, this aggregate is trapped in the oligomeric state with fibril-like β-sheets (Panel C of S1 Fig of SI). The residues G25-G29 form a sharp turn in this model with a distance of 7.8 ...
36