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AMP-Activated Protein Kinases

Rôle du couple Flt3-ligand/Flt3 et de l'activation des "Mitogen-activated protein kinases" p38 dans la dysmégacaryopoïèse des patients atteints de myélofibrose primitive

Rôle du couple Flt3-ligand/Flt3 et de l'activation des "Mitogen-activated protein kinases" p38 dans la dysmégacaryopoïèse des patients atteints de myélofibrose primitive

... Les isoformes ERK1 et ERK2 sont ubiquitaires, elles partagent 83 % d’identité en acides aminés et sont exprimés dans la totalité des tissus. Elles sont très fortement activées par les facteurs de croissance, les esters ...

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AMP-activated protein kinase as a target for pathogens: friends or foes?

AMP-activated protein kinase as a target for pathogens: friends or foes?

... Especially protein kinases are important regulators of virus-host interaction and many different host cell signaling pathways are subverted to enable the generation of the next round of infectious ...

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en fr AMP-activated protein kinase : Screening for novel membrane substrates and creatine kinase phosphorylation linked to specific subcellular compartment La protéine kinase activée par AMP : Criblage de nouveaux substrats membranaires et phosphorylation de la créatine kinase liée à une compartimentation subcellulaire

... de la procédure et la pureté des protéines. Dans ce travail de thèse, un système de chromatographie thermostaté haut de gamme (Äkta Explorer) a été modifié de telle manière qu'une purification automatique des protéines ...

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Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism

Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism

... AMPK-related kinases in the regulation of metabolism LKB1 is a master kinase that phosphorylates and activates AMPK and also a family of 12 closely related protein kinases, including SIK ...

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Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1

... Copyright © 2017 P. Rowart et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...

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Place de l'AMP-activated protein kinase dans le preconditionnement ischemique renal.

Place de l'AMP-activated protein kinase dans le preconditionnement ischemique renal.

... entraıˆne la liaison d’ADP ou d’AMP a` la sous-unite´ g . Cet e´ve´nement permet la phosphorylation et l’activation de la sous- unite´ a , et s’accompagne de modifications alloste´riques de l’AMPK phosphoryle´e, la ...

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The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes

The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes

... inhibitor selective for the p38 α and β isoforms 14 . Both inhibitors (U0126 and SB239063) significantly reduced the production of IL-8/CXCL8 by HaCaT Cells stimulated with MSU (Figure 5). Gene expression profiling of ...

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AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.

AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.

... many protein kinases involved in cell ...of AMP-activated protein kinase alpha1 subunit in mouse would prevent enhanced oxidative stress and lung injury induced by ozone ...

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AMP-Activated Protein Kinase Signalling

AMP-Activated Protein Kinase Signalling

... several kinases capable of phosphorylating AMPK at Thr-172 in the .../Calmodulin-dependent protein kinase kinase 2 (CaMKK2) are firmly established as physiological upstream kinases of ...

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AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts

... 5’-AMP-activated protein kinase (AMPK) in energy homeostasis, we hypothesized that targeting glycolysis (MCT-blockade) in AMPK-null (Ampk -/- ) cells should kill tumour cells from ‘ATP ...

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Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

... Tropomyosin-Related Kinases (Trks) Tropomyosin-related kinases (Trks) are frequently cited as targets for pain ...tropomyosin-related kinases (Trks) are cell surface receptor tyrosine kinases ...

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Rôles physiologiques de l’AMP-activated protein kinase (AMPK)

Rôles physiologiques de l’AMP-activated protein kinase (AMPK)

... L’AMP-activated protein kinase (AMPK), enzyme ubiquitaire, est proposée comme le détecteur métabolique de la cellule lui per- mettant de s’adapter aux modifications de son environnement [1] ...

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Octacalcium phosphate crystals directly stimulate expression
of inducible nitric oxide synthase through p38 and JNK
mitogen-activated protein kinases in articular chondrocytes

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes

... activator protein; BCP = basic calcium phosphate; bp = base pair; CPPD = calcium pyrophosphate dihydrate; DMEM = Dulbecco's modified Eagle's medium; FBS = foetal bovine serum; IL = interleukin; JNK = c-Jun ...

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Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ?

Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ?

... Concluding remarks Significant progress has recently been made regarding the molecular mechanisms underlying NF-kB and IRF acti- vation. Whereas the central roles of the IKK, TBK1 and IKK-e kinase complexes are now well ...

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Regulation of the hepatocyte cell cycle: signaling pathways and protein kinases.

Regulation of the hepatocyte cell cycle: signaling pathways and protein kinases.

... rats. They further demonstrate that the cell cycle activity is partially restored by the adenosine derivate IFC-305 and suggest that the preservation of mitochondrial function may contribute to the recovery of ...

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Être AMP en Poitou-Charentes : Mieux comprendre les logiques d'emploi et les trajectoires des AMP

Être AMP en Poitou-Charentes : Mieux comprendre les logiques d'emploi et les trajectoires des AMP

... 03 pour aLLer pLus Loin Les dÉterminants territoriaux de L’empLoi ≥ Les résultats de cette première série d’analyses sont une confirmation d’hypothèses fortes formulées autour des résul- tats de l’Enquête Emploi 2007, ...

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L’AMP-activated protein kinase hypothalamique, régulateur essentiel du poids et de la prise alimentaire

L’AMP-activated protein kinase hypothalamique, régulateur essentiel du poids et de la prise alimentaire

... L’AMP-activated protein kinase (AMPK), constituée de trois sous-unités (une sous-unité catalytique α 1 ou α 2, deux sous-unités régulatrices β et γ ), est une enzyme ubiquitaire dont l’acti- vité dépend de ...

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Age paternel et AMP

Age paternel et AMP

... entre 1995 et 1999. Pour analyser l’âge paternel, nous avons dans un deuxième temps restreint notre étude aux partenaires de femmes âgées de 30 à 34 ans (n= 49 661 tentatives). Résultats. En AMP, un homme sur ...

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Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.

Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.

... recombinant protein, showed an RGD-binding activity in ...receptor-like kinases (RLK) and, based on the identity of the extracellular domains, belong to a gene subfamily, with at least 46 members (Shiu and ...

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