Alternative pre-mRNA splicing
A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells
... VEGFR1 mRNA level was observed upon treatment with rhVEGF 165 only ...VEGFR1 mRNA was not affected by VEGF 165 ...VEGFR1 pre-mRNA splicing in favor of its truncated splice variant ...
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The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B
... of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human ...of alternative splicing events that change after digitoxin ...the ...
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Alternative splicing of CNOT7 diversifies CCR4–NOT functions
... the pre-mRNA encoding the transmembrane protein CD44, with the nine constitutive (black boxes) and nine variable exons (white ...variable mRNA normalized against the constitutive CD44c2 /c3 ...
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The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing
... RNA splicing is a major regulatory mechanism for controlling eukaryotic gene ...single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity of ...
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Alternative Splicing of TAF6: Downstream Transcriptome Impacts and Upstream RNA Splice Control Elements
... the splicing pattern, we mutated these positions ...the splicing pattern ...an alternative hypothesis for the strong impact of this ...tive splicing [15,17,18,41], we employed the M-Fold ...
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Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing
... Dnm2 mRNA Trochet et ...Trans- splicing technology to reprogram the Dnm2-mRNA in vitro and in vivo in ...the pre-trans-splicing molecules leading to low rate of trans-splicing in ...
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Genome-wide dissection of the relationship linking chromatin state and pre-mRNA processing
... Two alternative mechanisms by which chromatin may influence alternative ...splicing. Alternative splicing decisions are affected by the nature of histone marks that are deposited on the ...
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Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma
... undergo pre-mRNA alterna- tive splicing leading to the synthesis of various protein isoforms with different biological properties [1] Splicing defects of critical genes have been causally ...
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Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?
... the splicing of P2RX7-B, -H and ...regulate splicing events and are involved in ...the alternative splicing of P2RX7-J and P2RX7-H, ...P2RX7 mRNA but given their relative high frequency ...
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Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs
... of alternative splicing by DNA methylation has been observed for ...influence pre-mRNA processing. As splicing occurs co-transcriptionally (48), we hypothesize that some of these TFs ...
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Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression
... Similarly to CDKs, the diversity of Cyclin family members has increased during evolution [5], and the mammalian and human genome encodes more than 30 Cyclins and Cyclin-like proteins [6]. Cyclins were initially ...
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FAK alternative splice mRNA variants expression pattern in colorectal cancer
... integrins. Alternative splicing of FAK pre-mRNA allows the inclusion, independently of each other, of the exons 13, 14, 16, and 31, respectively coding for the boxes 28, 6, 7, and Pro-Trp-Arg ...
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Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization
... promote alternative back-splicing ...and pre- mRNA circularization ( 30 ...SMN pre-mRNA in prox- imity of intronic Alu elements and its knockdown signif- icantly reduces the ...
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Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development
... Figure 4. Extensive postnatal AS transitions occur primarily without changes in gene expression a. RNA-seq data (UCSC browser) and RT-PCR assays (n=2 biological replicates) for AS events developmentally regulated (+ex: ...
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Proteasome inhibitors to alleviate aberrant IKBKAP mRNA splicing and low IKAP/hELP1 synthesis in familial dysautonomia
... Figure 3. Strong effects of carfilzomib on IKBKAP mRNA and IKAP/hELP1 protein profiles. Increasing doses of carfilzomib (1, 5, 10, 15, 20, 25, 30, 60, 125, 250, 500, 1000 nM) were applied on C1 and C3 hOE-MSCs ...
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Algorithms for simulating human pre-mRNA splicing decisions
... With a high cutoff, only high-scoring exons will be predicted. These exons are likely to be correct; however, the simulation will tend to miss low- and medium- sc[r] ...
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Alternative Splicing of RNA Triplets Is Often Regulated and Accelerates Proteome Evolution
... the splicing factor PTBP2 (also known as nPTB or ...for alternative splicing is conserved at the sequence level to lizard (Figure ...exhibit alternative splicing in their mouse ...
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Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy
... Mypbc3 pre-mRNA and an engineered pre-trans- splicing molecule (PTM) carrying a FLAG-tagged wild-type (WT) Mybpc3 cDNA ...Mybpc3 mRNA represented up to 66% of total Mybpc3 transcripts ...
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Alternative splicing dynamics and evolutionary divergence during embryogenesis in wheat species
... tissues, splicing bias was calculated and AS triads were categorized into one of three groups: (i) Balanced, in which PSI values for the three homoeologs of a triad are similar (with a PSI range of 0 –20) and ...
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In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin
... percent splicing index (PSI or Ψ) value was then estimated for each sample as the ratio of inclusion junction reads to the sum of inclusion and exclusion junction ...and splicing analysis by ...For ...
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