alkyladenine DNA glycosylase
Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)
... of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation ...nuclear DNA has been explored in detail, much less is known about the repair of DNA alkylation damage in ...
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
... To our knowledge, this is the first documented case where both loss and enhancement of DNA repair initiation has caused increased cell sensitivity to DNA damage co[r] ...
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Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1
... repairing DNA alkylation damage, under certain conditions, initiation of BER can be ...the alkyladenine DNA glycosylase (AAG) mediates alkylation-induced tissue damage and whole-animal ...
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DNA Replication Restart in Archaea
... In vitro experiments suggested collaboration between the coupled helicase and the nuclease domains of PfuHef: the helicase domain binds and processes the fork-structured DNA, forming a four-way structure that is ...
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DNA Labeling at Electron Microscopy
... morphological distinction between the subcellular components. Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase found in pre-lymphocytes and at early stages of lymphoid differentiation [15]. TdT ...
8
A predictable conserved DNA base composition signature defines human core DNA replication origins
... Quanti fication, classification, and differential activity of DNA replication origins. The bioinformatics on this project was supported by the high power computing cluster of University of Birmingham (CastLes and ...
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Nanopore DNA sequencing channel modeling
... for DNA synthesis (writing data as bases/nucleotides) and se- quencing (reading or retrieving the data), DNA-based storage is becoming ...for DNA data ...in DNA storage technologies was the ...
6
DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF
... DNA replication from the stalled forks and to prevent mitotic segregation ...induced DNA damage generated during the process of DNA replication when the DNA replication forks are slowed down ...
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High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes
... order to extend the application domain of the AFM to ssDNA and its partner proteins. It is generally known that the addition of divalent cations to the deposition buffer overcomes the natural repulsion between the ...
8
C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... the DNA ligase components as well as other accessory NHEJ ...(ds) DNA molecule ( 21 ...the DNA molecule when additional Ku proteins enter by the ends ( 22 , 23 , 24 ...the DNA ends the other ...
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Physicochemical study of DNA biochips: DNA duplex stability, point mutation detection and beyond
... 4.7. SUMMARY: REAL-TIME CHARACTERIZATION OF ODN CHIPS Otherwise, signals are likely to present drifts. Other stringent conditions like negative potentials applied to the sensor surface have not been treated here, but ...
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DNA studies using atomic force microscopy: capabilities for measurement of short DNA fragments
... induced DNA damage ( Murakami et ...short DNA fragments by high-LET radiations, Psonka-Antonczyk et ...investigated DNA breakage by Ni ions and observed a reduced average DNA fragment length ...
8
Chromatin Dynamics upon DNA Damage
... of DNA damage and genome ...upon DNA damage is an intrigu- ing phenomenon, and over the last five years, several views to explain it have been proposed in the ...the DNA response machinery; (2) ...
22
Hydrodynamic interactions in DNA thermophoresis
... of DNA thermophoresis, which arises from mutual advection of the n repeat units of the molecular ...single-stranded DNA (2 ≤ n ≤ 80), our theory quantitatively describes the increase of the drift velocity ...
6
A computational study of DNA four-way junctions and their significance to DNA nanotechnology
... B-form DNA duplex) for origami design was the antiparallel 4WJ, though parallel crossover (PX) systems had been extensively studied and applied by the Seeman lab in smaller constructs ...arbitrary DNA ...
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JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage
... JMJD6 is required for nucleolar caps formation The Treacle/NBS1 complex was also shown to be important for the relocalisation of rDNA at the nucleolar periphery in structures called nucleolar caps, upon induction of DSBs ...
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Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions
... inhibits DNA repair pathways ...marks DNA breaks in S phase, de- monstrated that γ-H2AX foci were mostly detected in Tax-expressing cells with replicating DNA ...during DNA replication and the ...
15
Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?
... conserved DNA repair mechanisms have been selected during evolution to cope with these various damages and maintain genomic ...Among DNA lesions, double-strand breaks (DSBs; see Glossary ) are considered ...
12
Analysis of radiation induced DNA damage by LC-MS/MS in isolated and cellular DNA
... in DNA in HeLa cells was initiated by intense nanosecond 266 nm Nd:Yag laser ...double-stranded DNA; as a result, the oxidatively generated DNA damage is predominantly localized at guanine ...ongoing ...
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Nano-DNA induced target assemblies - detection of small targets of DNA by forming networks
... 97 shown in Figure 3.13: First, similarly as for the classic approach, the S5*Zc sequence was injected to hybridize on the probes immobilized on the gold surface to form S5* functional probes. Then, instead of injecting ...
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