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Airway inflammation

Potential key role of ADAM28 in airway remodeling following eosinophilic airway inflammation

Potential key role of ADAM28 in airway remodeling following eosinophilic airway inflammation

... allergic inflammation (ovalbumin (OVA) sensitization) was induced in BALB/c, ADAM28 knock-out (KO) and corresponding wild-type ...RTPCR. Airway resistances were measured by using ...sorting. Airway ...

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Potential therapeutic target in a murine model of eosinophilic airway inflammation

Potential therapeutic target in a murine model of eosinophilic airway inflammation

... ADAM28 is soluble and a multipotent membrane-bound or secreted proteinase expressed by epithelial cells in human normal tissues. ADAM28 influences lymphocytes adhesion and migration, and cleaves the low affinity IgE ...

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PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse.

PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse.

... In mice, airway inflammation induced by LPS is associ- ated with an increase of the matrix metalloproteinases (MMP), MMP-2 and MMP-9 [7,8]. MMP are a family of zinc- and calcium-dependent endopeptidases ...

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Supplementing Defect in Club Cell Secretory Protein Attenuates Airway Inflammation in COPD

Supplementing Defect in Club Cell Secretory Protein Attenuates Airway Inflammation in COPD

... Anne-Sophie Gamez, Delphine Gras, Aurélie Petit, Lucie Knabe, Nicolas Molinari, Isabelle Vachier, Pascal Chanez, Arnaud Bourdin. To cite this version:[r] ...

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Bronchoalveolar lavage fluid cytology and cytokine messenger ribonucleic Acid expression of racehorses with exercise intolerance and lower airway inflammation.

Bronchoalveolar lavage fluid cytology and cytokine messenger ribonucleic Acid expression of racehorses with exercise intolerance and lower airway inflammation.

... associated with altered cytokine expression in the blood of human and equine athletes 35,36 but did not influence gene expression in BAL of horses in one study. 37 Cold air exercise has been associated with altered ...

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Associations of black carbon with lung function and airway inflammation in schoolchildren

Associations of black carbon with lung function and airway inflammation in schoolchildren

... to theoretical values based on sex, age, height and ethnicity, according to the Global Lung Initiative equations ( Quanjer et al., 2012 ) and ex- pressed as a percentage of the predicted value. The measurement of the ...

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The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for Th2-lymphocyte function and acute allergic airway inflammation

The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for Th2-lymphocyte function and acute allergic airway inflammation

... acute airway allergic inflammation Eight- to 12-week-old female BALB/c mice were obtained from Janvier (Le Genest St Isle, France), and TCR ovalbumin (OVA) transgenic ...

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Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation

Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation

... Time course of endothelial cell proliferation and microvascular re- modeling in chronic inflammation. Am J Pathol 2001, 158:2043–2055 31. Brown J, Cao AZ, Pinzon-Ortiz M, Kendrew J, Reimer C, Wen S, Zhou QJ, ...

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ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation

ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation

... bronchial inflammation and hyperresponsiveness [1, ...permanent airway obstruction along with wheezing, breathlessness and ...neutrophilic inflammation in the airways [5] and MMP-2 deficiency induces ...

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Time for reasoning ICS prescription in obstructive airway diseases.

Time for reasoning ICS prescription in obstructive airway diseases.

... The mirror conclusion of the GOAL study is, however, that 30% of asthmatics failed to respond to increasing the dose of inhaled corticoids thereby proving some corticosteroid resistance. Analysis of airway ...

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Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness

Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness

... exacerbated inflammation and augmented T H 2 cytokines in asthma models induced by house dust mite extract or OVA as ...allergic airway inflammation ...

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Inflammation et douleur : thérapie génique expérimentale

Inflammation et douleur : thérapie génique expérimentale

... d’une inflammation péri- phérique, des molécules synthétisées et libérées dans le foyer inflammatoire, comme les prostaglandines, la bra- dykinine, la sérotonine, certaines cytokines et le NGF (nerve growth ...

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Inflammation pulmonaire et rôle des microARN dans la mucoviscidose

Inflammation pulmonaire et rôle des microARN dans la mucoviscidose

... Mais le volume du liquide des VA est le résultat d’un équilibre entre la quantité de fluide sécrété et absorbé. L’absence de CFTR entraîne une levée de l’inhibition d’ENaC et par conséquent une augmentation de ...

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Alimentation et inflammation : considérations épidémiologiques, cliniques et métaboliques

Alimentation et inflammation : considérations épidémiologiques, cliniques et métaboliques

... The nutrient-poor food pattern in the present study of Inuit from Nunavik was positively associated with oxidized-LDL concentrations (P trend = 0.04, Table 3), but, unexpectedly, showed an inverse association with hs-CRP ...

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View of Inflammation and sepsis

View of Inflammation and sepsis

... L ’objectif de cette étude était d’évaluer les pratiques actuelles et les croyances des réanimateurs concernant le délai optimal d ’initiation de ventilation invasive chez les patients en choc septique. Matériels et ...

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Microbiota, inflammation and colorectal cancer

Microbiota, inflammation and colorectal cancer

... In vivo, supplementation of gastrin leads to increased proliferative index in the colon, expansion of the proliferative zone in the intestinal crypt, increased thickness of the colonic mucosa and hyperplasia of goblet ...

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Immune activation and chronic inflammation

Immune activation and chronic inflammation

... The objectives of the study were to assess 29 blood markers of immune activation and in flammation using an ultrasensitive technique, in HIV-infected patients aged ≥75years with no or 1 c[r] ...

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Inflammation et regénération musculaire : une arme à double tranchant

Inflammation et regénération musculaire : une arme à double tranchant

... SUMMARY Inflammation and muscle regeneration, a double-edged sword Muscle injuries are very frequent and are associated with an inflam- matory reaction that varies in ...

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Modeling shear stress distribution in a deformable airway tree

Modeling shear stress distribution in a deformable airway tree

... SHEAR STRESSES IN A RIGID AIRWAY TREE A model with rigid bronchi will be used in this section. This hypothesis is a good first approximation for proximal bronchi that are quite rigid as they are partly ...

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Inflammation et rémission symptomatique et fonctionnelle dans le trouble schizophrénique

Inflammation et rémission symptomatique et fonctionnelle dans le trouble schizophrénique

... Une inflammation périphérique chronique a été identifiée chez environ un tiers des sujets ayant une schizophrénie stabilisée (Fond et ...une inflammation centrale (ou neuro-inflammation) (Felger et ...

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