adrenocortical cells
Adrenocorticotropin/3′,5′-Cyclic AMP-Mediated Transcription of the Scavenger akr1-b7 Gene in Adrenocortical Cells Is Dependent on Three Functionally Distinct Steroidogenic Factor-1-Responsive Elements
... extent, mutations of the ⫺503B site markedly reduce fors- kolin sensitivity of the ⫺510/⫹41 promoter, indicating that the proximal sites are not sufficient for full cAMP respon- siveness. Numerous cell transfection ...
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mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)
... the adrenocortical mouse cell line ATC7 ( 17 ) ...H295R cells, rpS6 phosphorylation was significantly inhibited by rapamycin or H89 treatment (P , ...
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Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells: Mitotane-induced cytochrome c oxidase defect
... SW13 cells, which do no express CYP11B1, were similarly affected by mitotane ...H295R cells, suggesting that intracellular accumulation of mitotane and/or one of its metabolites may account for its ...
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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?
... cultured adrenocortical cells decreases the expression of MC2R and of various steroidogenic enzymes, both in basal conditions and after cAMP stimulation ( 10 ), suggesting that it may interfere with PKA ...
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The cAMP pathway and the control of adrenocortical development and growth
... mice, cells of the “normal” ZF and/or progenitor recruitment could still be partially dependent on ACTH release by the ...ZF cells in AdKO mice. In AdKO mice, adrenocortical cells displayed ...
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The Wnt/beta-catenin pathway in adrenocortical development and cancer
... human adrenocortical cells, including effects on overall steroidogenesis (aldosterone and cortisol biosynthesis) and distinct effects on steroidogenic enzyme mRNA ...human adrenocortical ...
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Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors
... human adrenocortical cells H295R, showed that ARMC5 gene silencing alters the expression of genes involved in steroidogenesis leading to a global decreased of cortisol secretion ( 15 ) (Figure ...
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novel insights into the genetics and pathophysiology of adrenocortical tumors
... human adrenocortical cells H295R, showed that ARMC5 gene silencing alters the expression of genes involved in steroidogenesis leading to a global decreased of cortisol secretion ( 15 ) (Figure ...
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Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
... in adrenocortical carcinoma ...on adrenocortical cells ...H295R cells, then PCR using oligonucleotides corresponding to sequences in exon 3 and exon 5, followed by agarose gel electrophoresis; ...
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Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
... 1,2,3 Adrenocortical cancer (ACC) is a very aggressive tumor, and genomics studies demonstrate that the most frequent alterations of driver genes in these cancers activate the Wnt/β-catenin signaling ...in ...
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Celecoxib reduces glucocorticoids in vitro and in a mouse model with adrenocortical hyperplasia
... adrenocortical cells. Celecoxib is a cyclooxygenase 2 (COX2) inhibitor. In bone, Prkar1a inhibition is associated with COX2 activation and prostaglandin E2 (PGE2) production that, in turn, activates ...
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Human mucosal associated invariant T cells detect bacterially infected cells.
... MAIT Cells We next performed phenotypic analyses of Mtb-reactive MR1- restricted T-cell clones to determine if they shared properties of previously characterized MR1-restricted MAIT ...MAIT cells is the ...
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Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells
... target cells The cDNA of FluM1 of in fluenza strain A/Puerto Rico/8/34 (H1N1) was cloned from pMA_MPT_matrx_protein (kindly provided by Dr Mai Ping Tan, Cardiff University) between the SalI and XmajI cloning sites ...
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Deformability of Tumor Cells versus Blood Cells
... The observation of deformable CTCs, of course, does not preclude the existence of other, stiffer CTCs in the circulation having longer passage times, similar to those of cells from tumor cell lines. The current ...
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EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
... 36. Gao, S.-B., Zheng, Q.-F., Xu, B., Pan, C.-B., Li, K.-L., Zhao, Y. et al. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Mol. Cancer Res. 12, 1388 ...
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Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells
... It has been recently described in mice that the ICAM-1- binding CD11a/CD18 heterodimer (LFA-1) controls Tfh generation and maintenance, and is involved in the development of IL-4 producing Tfh and Th2 cells during ...
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IGF2 Promotes Growth of Adrenocortical Carcinoma Cells, but Its Overexpression Does Not Modify Phenotypic and Molecular Features of Adrenocortical Carcinoma
... of adrenocortical carcinoma could not distinguish between IGF2-high and IGF2-low tumors, and although there were some differences in the transcriptome profiles between these two groups of tumors in the supervised ...
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Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic Acid microarrays identifies several candidate genes as markers of malignancy.
... of adrenocortical tumors is still ...that adrenocortical tumorigenesis is a multistep process resulting from sequential genetic alterations leading to progression from normal to adenomatous and, eventually, ...
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Innate lymphoid cells
... lymphoid cells Innate Lymphoid Cells (ILC) are tissue-resident effec- tor lymphocytes that differ from the B and T lympho- cytes subsets since they lack specific antigen receptors derived from gene ...(NK ...
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Cells and cacti
... Remark 4.4 . — In the equal parameter case, Mathas proved moreover that the sign map w 7→ η I w is constant on two-sided cells. However, this property does not hold in general, as it can be seen from direct ...
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