Acute liver injury
Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System
... (protopathic bias). Indeed, drugs most often first dispensed within 7 days before index date were symptomatic medications (analgesics, antiemetics, propulsives) that could be related to the symptoms of hepatic ...
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Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat.
... MnDPDP-pretreated livers when compared to levels found in I/R group. This effect supports an antioxidant action of MnDPDP in the post-ischemic liver tissue. Using different models of stress, previous studies ...
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Hypothermia in acute liver failure
... expected in patients with ALF in whom ICP cannot be controlled. In addition, 30–40% of patients with ALF die while waiting for a donor organ to become available, primarily due to the effects of increased ICP. In our ...
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EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
... impairments supported that ATP synthase was damaged by anoxia/reoxygenation. These results on isolated liver mitochondria showed that in vitro anoxia/reoxygenation induced mitochondrial dysfunction. In the same ...
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Neuropathological changes in the brain of pigs with acute liver failure
... Keywords: Acute liver failure, ammonia, blood-brain-barrier, cerebral edema, hepatic encephalopathy I NTRODUCTION Cerebral edema is a serious complication of acute liver failure (ALF), which ...
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Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury
... Ischemia/reperfusion injury (IRI) of the liver graft is considered as one of crucial problems complicating post-transplant patient care and influences short- and long-term outcomes after liver ...
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View of Acute kidney injury
... Matériels et méthodes : Sur la période de 2001 à 2011, tous les dossiers des patients admis en réanimation avec une leptospi‑ rose confirmée biologiquement ont été étudiés. Seront relevées les caractéristiques cliniques ...
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Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury
... the acute brain injury were subarachnoid hemorrhage (5 patients), trau- matic brain injury (3), intracerebral hemorrhage (4), cardiac arrest (2), neurosarcoidosis (1), and bupropion overdose (1) ...
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Parallel recovery of consciousness and sleep in acute traumatic brain injury
... that assessment of the sleep-wake cycle in acute TBI may be a useful tool for monitoring patient evolution and recovery. Moreover, the possibility of a positive feedback action of improved consolidation of sleep ...
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Contractile response of femoral arteries in pigs with acute liver failure
... in liver failure may result either from the presence of excessive vasorelaxing factors or an impairment of the contractile apparatus of the vascular smooth muscle ...
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Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
... I/R injury, and that such protection is observed across three different ...in liver, kidney, and brain, Aag −/− mice display de- creased hepatocyte death, cerebral infarction, and renal injury rel- ...
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Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context
... the liver and kidneys, in agreement with the decreased mitochondrial oxidative capacity previ- ously observed in GSD1a [44] ...the liver of obese/diabetic patients originates from NEFA, 10% originating from ...
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Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction.
... of liver injury in patients with DILI in the absence of ALF ...hyperacute liver failure with the rapid (within 7 days usually) progression from onset of synthetic dysfunction to the development of ...
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Gene Expression Profiles Characterize Inflammation Stages in the Acute Lung Injury in Mice
... An intermediate spreading of inflammation The transition phase at 3 hours –4 hours which followed the pro-inflammatory phase corresponds to the spreading of inflam- mation. Among genes whose expression level reaches a ...
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Poly(ADP-ribose) polymerase inhibition in acute lung injury. A reemerging concept
... reperfusion injury is sex-specific; in most (but not all) cases, male animals benefit more (as well as aged females and ovariectomized females), whereas the protective effect of PARP inhibitors in females is less ...
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Early detection of consciousness in patients with acute severe traumatic brain injury
... with acute severe traumatic brain injury may recover consciousness before ...for acute severe traumatic brain injury to test two hypotheses: (i) in patients who lack behavioural evidence of ...
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View of Renal Doppler Ultrasound for the Management of Acute Kidney Injury
... Mots clés Doppler · Indice de résistance · Insuffisance rénale aiguë · Diagnostic · Contrast-enhanced ultrasound Abstract Renal Doppler has been proven to be a valuable tool for assessing large arteries and veins of the ...
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Intracellular lipids: an independent cause of liver injury and chronic kidney disease in non-alcoholic fatty liver disease-like context
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Cerebral edema and acute liver failure : pathophysiological mechanisms and new therapeutic approaches
... Keywords: acute liver failure; brain edema; hepatic devascularization; hypothermia; microglial activation; proinflammatory cytokines I ntro du c ti on ALF that results from viral infection or toxic ...
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Acute Kidney Injury in Traumatic Brain Injury Patients: Results From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study
... Brain Injury is a multicenter, prospective observational, longitudinal, cohort ...brain injury patients with an ICU length of stay greater than 72 hours and with at least two serum creatinine values during ...
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