Actin dynamics
Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant
... investigate actin dynamics in live cells, we constructed strains carrying a Pact1-LifeAct-GFP reporter, which allows visualization of the actin cytoskeleton in living cells ( Huang et ...on ...
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Insights into the evolution of regulated actin dynamics via characterization of primitive gelsolin/cofilin proteins from Asgard archaea
... eukaryotic actin regulation systems. ProGel showed clear actin filament localization ...equivalent actin-regulating properties (monomer sequestration, filament nucleation, bundling, and severing) to ...
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Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation
... altered myofibrillar organization compared with transfection with a plasmid encoding the cofilin-1 T25A variant. Discussion We have shown that ERK1/2-catalyzed phosphorylation of cofilin-1 in cells expressing a ...
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Platelet adhesion: structural and functional diversity of short dystrophin and utrophins in the formation of dystrophin-associated-protein complexes related to actin dynamics.
... minor actin-binding proteins present in muscle and non-muscle ...the actin cytoskeleton was evaluated by confocal microscopy in both resting and platelets adhered on ...the actin cytoskeleton was ...
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Actin dynamics in the cell cytoplasm and the role of actin associated proteins
... The state of the actin cycle is specified by any three of the following parameters: the average length of filaments, the rate of filament turnover, the fraction of actin polymerized, [r] ...
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Cell Polarity: Focal Adhesion and Actin Dynamics in Migrating Cells
... The best way to optimize the filter settings is to display the background image and compare with the original (check "create back- ground" in the options). • Auto Threshold [I[r] ...
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Dynamic reorganization of the actin cytoskeleton
... of actin structure may only provide an incomplete view of its formation and maintenance in ...one actin structure at a time should improve the under- standing of the complexity of cellular actin ...
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Actin cytoskeleton: Thinking globally, actin’ locally
... regulating actin dynamics ...of actin polymerization in certain regions of the lamellipodia, and repression of actin dynamics in other regions ...regulating actin assembly during ...
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Dynamic stability of the actin ecosystem
... polymerizable actin is bound to profilin ...some actin monomers in a given cell type might not be polymerizable as they can be sequestered by proteins such as thymosin β4 (Tβ4) ...polymerizable actin ...
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Confinement induces actin flow in a meiotic cytoplasm.
... an actin cloud with the presence of a flow of ...F-actin dynamics within droplets showed network remodeling with both filaments nucleation at the boundary con- dition and filament transport directed ...
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Triggering signaling pathways using F-actin self-organization
... F-actin dynamics activate microtubule assembly after the local accumulation and the cytoplasmic partitioning of ...recognize actin microfilaments using an actin binding protein based on ...
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Tau co-organizes dynamic microtubule and actin networks.
... for actin assembly (Fig. 1c) or actin/ tubulin co-assembly (Supplementary ...affect actin assem- bly properties by using pyrene-actin polymerization and F-actin sedimentation ...
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Adaptive Response of Actin Bundles under Mechanical Stress
... how actin bundles reorganize during the waiting time, pictured by the increase in the hysteresis, may imply more complex deformations of the bundle, these are not taken into account in our current ...the ...
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Actin network architecture determines myosin motor activity
... the actin nucleating protein, WASp, features which suggested that it could play a role in cytoskeletal ...are actin-based structures that mediate adhesion, chemotaxis, and ECM degradation in myeloid- ...
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Binding of human angiogenin inhibits actin polymerization
... of actin polymerization, but angiogenin–angiogenin affinity may change considerably upon the formation of the actin/angiogenin ...oligomerized actin may promote the formation of amyloid-like ...
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The many implications of actin filament helicity
... each subunit is tilted by an additional ~9.5° with respect to its longitudinal neighbors. The length of the filament is not significantly affected but the helical pitch of cofilactin is shorter, with a half-pitch of ...
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Computational study of actin morphology and rheology
... concentration and type of ACPs, the mechanical stiffnesses of actin filaments and ACPs, and the thermal fluctuation of actin filaments on viscoelastic properties of n[r] ...
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Actin filaments regulate microtubule growth at the centrosome
... for actin filaments at the ...centrosomal actin filaments provide a conduit through which changes to actin networks at the cell periphery modulate the formation and growth of microtubules emanating ...
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Mechanics of Biomimetic Liposomes Encapsulating an Actin Shell
... Let us now address the viscous regime observed for cor- tex liposomes. Due to the corral effect, the dissipation mechanism is different than in bulk liposomes. For cortex liposomes, the lipid mobility is strongly reduced ...
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Actin kinetics shapes cortical network structure and mechanics
... cells, actin filaments of the submembranous cortex are nu- cleated primarily by the Arp2/3 complex and the formin Diaph1 ...nucleate actin fila- ments and remain attached to their barbed ends, where they ...
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